Effect of ultra short-acting β1-adrenergic receptor blocker on cardiac muscle as an immunomodulation therapy under excessive stress.
| Project/Area Number |
20592119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TSUJITA Yasuyuki Shiga University of Medical Science, 医学部, 講師 (60343224)
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| Co-Investigator(Renkei-kenkyūsha) |
EGUCHI Yutaka 滋賀医科大学, 医学部, 教授 (00263054)
SAOTOME Takao 滋賀医科大学, 医学部, 准教授 (60311726)
HAMAMOTO Tetsu 滋賀医科大学, 医学部, 助教 (40378469)
YAMANE Tetsunobu 滋賀医科大学, 医学部, 助教 (50464194)
HAYAFUJI Kiyoyuko 滋賀医科大学, 医学部, 助教 (10447881)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 集中治療医学 / β遮断薬 / 炎症性サイトカイン / 全身性炎症反応症候群 / 心機能 / 心筋保護 / 心房細動 |
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| Research Abstract |
Patients of paroxysmal atrial fibrillation with a rapid ventricular response caused by SIRS were injected with landiolol, a short-acting selective β1-adrenergic receptor blocker and the changes in heart rate and blood pressure were recorded, hemodynamic parameters including cardiac index were measured, and the serum levels of inflammatory cytokines were measured. Next, we compared the effects of landiolol, digoxin, cibenzoline, and verapamil for patients with paroxysmal atrial fibrillation and a rapid ventricular response caused by SIRS. Landiolol certainly decreased the heart rate without inducing a massive decline in blood pressure. Landiolol decreased cardiac index, but increased the stroke volume index. Landiolol decreased the serum levels of interleukin-6. Landiolol decreased the heart rate more than the other drugs. The blood pressure lowering effect of landiolol was comparable to those of cibenzoline and verapamil. The success rate of pharmacological cardioversion using landiolol was higher than that using digoxin or verapamil, and was nearly equal to that using cibenzoline.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)2009
Author(s)
Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kanda H, Kita Y, Kadowaki T, Tsujita Y, Chowdhury Turin T, Horie M, Miki T, Ueshima H.
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Journal Title
Int J Cardiol 136
Pages: 354-355
Related Report
Peer Reviewed
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[Journal Article] A surviving case of mitochondrial cardiomyopathy diagnosed from the symptoms of multiple organ dysfunction syndrome2008
Author(s)
Tsujita Y, Kunitomo T, Fujii M, Furukawa S, Otsuki H, Fujino K, Hamamoto T, Tabata T, Matsumura K, Sasaki T, Saotome T, Kawai H, Matsumoto T, Maeda K, Horie M, Eguchi Y
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Toxicokinetics of digoxin that was ingested with suicidal intent : Report of a nonfatal case.2008
Author(s)
Konishi H, Tabata T, Tsujita Y, Hamamoto T, Matsumura K, Fujino K, Otsuki H, Furukawa S, Sasaki T, Saotome T, Eguchii Y, Sumi M, Sudo M, Uenishi K, Hoshino N, Minouchi T, Yamaji A
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Journal Title
Jpn J TDM 25
Pages: 104-109
Related Report
Peer Reviewed
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