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Is a novel prognostic marker for post cardiac arrest brain injury beneficial or detrimental?

Research Project

Project/Area Number 20592121
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionYamaguchi University

Principal Investigator

IZUMI Tomonori  Yamaguchi University, 大学院・医学系研究科, 准教授 (00261694)

Co-Investigator(Kenkyū-buntansha) KASAOKA Shunji  山口大学, 大学院・医学系研究科, 准教授 (90243667)
MAEKAWA Tsuyoshi  山口大学, 大学院・医学系研究科, 教授 (60034972)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords蘇生後脳症 / 予後予測 / バイオマーカー / 病態マーカー / 翻訳後修飾 / タンパク質相互作用 / プロテオーム / タンパク質間相互作用
Research Abstract

Molecular structures, functions, and cellular components of a novel prognostic marker for post cardiac arrest brain injury were investigated. The marker protein was expressed and localized in the cytoplasm and/or nucleus of cultured cells under the physiological conditions. In contrast, the marker protein was released into the extracellular space, and underwent a unique post-translational modification under the stress conditions. Because we were not able to establish a stable cell line expressing the marker protein constitutively, it might be possible that the increased expression of the marker protein followed by the release into the extracellular space could be detrimental to the clinical course of post-cardiac arrest brain injury

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Activation of synoviolin promoter in rheumatoid synovial cells by a nover transcription complex of interleukin enhancer bindine factor 3 and GA binding protein alpha.2009

    • Author(s)
      Toshihiko Izumi
    • Journal Title

      Arthritis Rheum 60

      Pages: 63-72

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracelllar adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia.2008

    • Author(s)
      Kenji Fuj imoto
    • Journal Title

      Pancreas 37

      Pages: 176-181

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 敗血症患者血清中のTNFα誘導性タンパク質の動態解析2009

    • Author(s)
      秋吉祐樹, 泉友則, 宮内崇, 前川剛志
    • Organizer
      第82回日本生化学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 敗血症患者血清中のTNFα誘導性タンパク質の動態解析2009

    • Author(s)
      秋吉祐樹
    • Organizer
      第82回日本生化学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心肺停止蘇生後脳症患者脳脊髄液のショットガンプロテオーム解析2009

    • Author(s)
      泉友則, 小田泰崇、荒木由佳、大村真裕子、秋吉祐樹、鶴田良介、笠岡俊志、前川剛志
    • Organizer
      第4回医学系研究科ライフサイエンスセミナー「ゲノムからプロテオームへ、そして」,日本ヒトプロテオーム機構(JHUPO)第7回サテライトシンポジウム合同会議
    • Place of Presentation
      宇部
    • Year and Date
      2009-07-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 心肺停止蘇生後脳症患者脳脊髄液のショットガンプロテオーム解析2009

    • Author(s)
      泉友則
    • Organizer
      第4回 医学系研究科ライフサイェンスセミナー「ゲノムからプロテオームヘ、そして」,日本ヒトプロテオーム機構(JHUPO)第7回サテライトシンポジウム合同会議
    • Place of Presentation
      宇部市
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性脳障害患者脳脊髄液のショットガンプロテオーム解析2009

    • Author(s)
      泉友則, 小田泰崇、荒木由佳、大村真裕子、秋吉祐樹、鶴田良介、笠岡俊志、前川剛志
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第7回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] SH3結合ドメインを欠くSH3BGR familyタンパク質SH3BGRL3のタンパク質間相互作用2008

    • Author(s)
      秋吉祐樹, 泉友則, 大村真裕子, 荒木由佳, 前川剛志
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 重症頭部外傷における脳脊髄液タンパク質の大規模定量解析2008

    • Author(s)
      荒木由佳, 山下哲平, 市原清志, 泉友則, 前川剛志
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Hair follicleタンパク質の大規模高感度解析2008

    • Author(s)
      大村真裕子
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] SH3結合ドメインを欠くSH3BGR familyタンパク質SH3BGRL3のタンパク質問相互作用2008

    • Author(s)
      秋吉祐樹
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ショットガン法を利用した臨床検体からの大規模タンパク質同定と病態解析への応用2008

    • Author(s)
      泉友則, 前川剛志
    • Organizer
      The 7th Cell Biology Summer Meeting
    • Place of Presentation
      鴨川
    • Year and Date
      2008-07-05
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 重症頭部外傷患者脳脊髄液の大規模タンパク質解析2008

    • Author(s)
      荒木由佳, 大村真裕子, 山下哲平, 秋吉祐樹, 市原清志, 泉友則, 前川剛志
    • Organizer
      第49回日本生化学会中国・四国支部例会
    • Place of Presentation
      高松
    • Year and Date
      2008-05-17
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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