Is a novel prognostic marker for post cardiac arrest brain injury beneficial or detrimental?
| Project/Area Number |
20592121
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
IZUMI Tomonori Yamaguchi University, 大学院・医学系研究科, 准教授 (00261694)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KASAOKA Shunji 山口大学, 大学院・医学系研究科, 准教授 (90243667)
MAEKAWA Tsuyoshi 山口大学, 大学院・医学系研究科, 教授 (60034972)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 蘇生後脳症 / 予後予測 / バイオマーカー / 病態マーカー / 翻訳後修飾 / タンパク質相互作用 / プロテオーム / タンパク質間相互作用 |
|---|
| Research Abstract |
Molecular structures, functions, and cellular components of a novel prognostic marker for post cardiac arrest brain injury were investigated. The marker protein was expressed and localized in the cytoplasm and/or nucleus of cultured cells under the physiological conditions. In contrast, the marker protein was released into the extracellular space, and underwent a unique post-translational modification under the stress conditions. Because we were not able to establish a stable cell line expressing the marker protein constitutively, it might be possible that the increased expression of the marker protein followed by the release into the extracellular space could be detrimental to the clinical course of post-cardiac arrest brain injury
|
Report
(4 results)
Research Products
(14 results)
-
-
-
-
-
[Presentation] 心肺停止蘇生後脳症患者脳脊髄液のショットガンプロテオーム解析2009
Author(s)
泉友則, 小田泰崇、荒木由佳、大村真裕子、秋吉祐樹、鶴田良介、笠岡俊志、前川剛志
Organizer
第4回医学系研究科ライフサイエンスセミナー「ゲノムからプロテオームへ、そして」,日本ヒトプロテオーム機構(JHUPO)第7回サテライトシンポジウム合同会議
Place of Presentation
宇部
Year and Date
2009-07-29
Related Report
-
-
-
-
-
-
-
-
-
