Role of C/EBPβ, a transcription factor in neutrophils, in the pathogenesis of septic acute lung injury
| Project/Area Number |
20592125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SHIME Nobuaki Kyoto Prefectural University of Medicine, 医学研究科, 講師 (00260795)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Hideyo 京都大学, 医学研究科, 助教 (50315933)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | 集中治療医学 / 好中球 / 急性肺損傷 / 敗血症 / 転写因子 / C/EBPβ / C / EBPβ / 造血過程 / フローサイトメーター |
|---|
| Research Abstract |
The purpose of this study is to obtain basic data for maintaining proper body weight by controlling obesity following childbirth. The levels of autonomic nerve activity and body composition were measured in pregnant and puerperal women by analyzing the power spectra of heat rate fluctuations. Results 1) Parasympathetic nerve activity decreased while sympathetic nerve activity increased in the third trimester as compared with the second trimester. 2) Increased body fat percentage, decreased muscle volume and increased autonomic nerve activity were confirmed following childbirth. The results of this study can be applied to the development of a proper weight management program for use after childbirth by monitoring BMI and body composition starting one year after childbirth.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Identification of a myeloid committed progenitor as the cancer initiating cell in acute promyelocytic leukemia.2009
Author(s)
Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG
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Journal Title
Blood 114(27)
Pages: 5415-5425
Related Report
Peer Reviewed
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[Journal Article] Fas ligand released by activated monocytes causes apoptosis of lung epithelial cells in human acute lung injury model in vitro.2008
Author(s)
Mizuta M, Nakajima H, Mizuta N, Kitamura Y, Nakajima Y, Hashimoto S, Matsuyama H, Shime N, Amaya F, Koh H, Ishizaka A, Magae J, Tanuma SI, Hashimoto S.
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Journal Title
Biol Pharm Bull 31
Pages: 386-390
NAID
Related Report
Peer Reviewed
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[Presentation] Candidemia-Induced Emergency Granulopoiesis Consist of Successive Dual Waves Triggered by the Shift from C/EBPalpha Dependency to C/EBPbeta Dependency.2010
Author(s)
佐竹早紀子, 平位秀世, 志馬伸朗, 長尾里奈, 田中瑠璃子, 八尾尚幸, 林嘉宏, 稲葉亨, 藤田直久, 今西二郎, 前川平
Organizer
52st ASH ANNUAL MEETING AND EXPOSITION
Place of Presentation
ORLAND
Year and Date
2010-12-06
Related Report
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[Presentation] 敗血症による2相性"緊急"好中球造血のフローサイトメトリーによる解析2010
Author(s)
佐竹早紀子, 平位秀世, 志馬伸朗, 長尾里奈, 田中瑠璃子, 八尾尚幸, 林嘉宏, 武内美紀, 芦原英司, 稲葉亨, 藤田直久,今西二郎, 前川平
Organizer
第72回日本血液学会学術集会
Place of Presentation
横浜
Year and Date
2010-09-24
Related Report
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[Presentation] 「骨髄系細胞の分化と機能制御」「緊急」顆粒球造血時のC/EBPβの制御におけるCREBファミリー転写因子2010
Author(s)
Hirai H, Kamio N, Matsusue A, Ogino S, Kimura N, Satake S, Tanaka R, Nagao R, Yao H, Hayashi Y, Takeuchi M, Ashihara E, Huang G, Tenen DG, Imanishi J, Maekawa T
Organizer
第72回日本血液学会学術集会
Place of Presentation
横浜
Year and Date
2010-09-24
Related Report
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