| Project/Area Number |
20592126
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
SUWABE Akira Iwate Medical University, 医学部, 教授 (20241713)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGASAWARA Rie 岩手医科大学, 医学部, 助教 (70347871)
CHIDA Syoichi 岩手医科大学, 医学部, 教授 (30108930)
ENDO Shigeatsu 岩手医科大学, 医学部, 教授 (30160394)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | ARDS / 肺表面活性 / MBテスト / マイクロバブルテスト |
|---|
| Research Abstract |
The number of microbubbles (MB) in the aspirated specimen from the airway was measured to speculate the native surfactant activity in the patients with acute respiratory distress syndrome (ARDS). If the MB numbers were small, we could differentiate whether they had an insufficient amount of surfactant or they had an inhibitory activity to surfactant, by adding the specimen to the artificial surfactant (Surfactant-TA, 0.1 mg/ml) as a positive control. It was noticeable that there was a patient whose MB number decreased with his clinical course and also that his inhibitory activity was increased to 85.9 % in the last sample 4 days before his death. These results may provide a judgmental hint whether the physician administrates the artificial surfactant to the patients with ARDS or not.
|
