| Project/Area Number |
20592136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOZAKI Ken-Ichi Tokyo Medical and Dental University, 難治疾患研究所, 准教授 (50270715)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
INAZAWA Johji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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|---|
| Keywords | 分子腫瘍学 / 口腔癌 / 扁平上皮癌 / microRNA / がん遺伝子 / がん抑制遺伝子 / エピゲノム異常 / DNA過剰メチル化 |
|---|
| Research Abstract |
In this study, we performed function-, methylation- and expression-based screening in oral cancer cell lines, and identified two novel tumor-suppressive microRNAs, miR-218 and miR-585, silenced by DNA hypermethylation in oral cancer. Moreover, we found that Rictor is a novel target of miR-218, suggesting that miR-218 targeting Rictor may provide a novel strategy for the treatment of oral cancer.
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