Evaluation of immune regulation against oral commensal bacteria and its impact on host protection against infection.

• Project/Area Number: 20592137
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: ISODA Ryutaro Osaka University, 大学院・歯学研究科, 特任研究員 (40456942)
• Co-Investigator(Kenkyū-buntansha): KAWABATA Shigetada 大阪大学, 大学院・歯学研究科, 教授 (50273694) ; TERAO Yutaka 大阪大学, 大学院・歯学研究科, 准教授 (50397717)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 口腔細菌学 / 歯周炎 / 動物モデル / 常在細菌 / 粘膜免疫 / 免疫寛容 / 歯周病原性細菌

Research Abstract

We tried to establish a new mouse model of human periodontal disease. The new model is based on the hypothesis that periodontal disease might be caused by commensal bacteria under certain conditions rather than by transient infection of foreign pathogens.
The method we used exposed the fetal mouse to human periodontopathic bacteria before other environmental bacteria are incorporated to the commensal bacterial flora of the new born mice.

Research Products

• [Journal Article] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. (2011)
  • Author(s): N.Okahashi
  • Journal Title: Microbial Pathogenesis Volume: 50 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion (2010)
  • Author(s): N.Okahashi
  • Journal Title: Biochemical and Biophysical Research Communications 391巻 Pages: 1192-1196
  • Peer Reviewed
• [Journal Article] Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis (2009)
  • Author(s): M.Yamaguchi
  • Journal Title: Biochemical and Biophysical Research Communications 390巻 Pages: 155-160
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans (2009)
  • Author(s): Y.Terao
  • Journal Title: Oral Microbiology and Immunology 24巻 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of gtfregulation-associated genes in Streptococcus mutans
  • Author(s): Y. Terao
  • Journal Title: Oral Microbiology and Immunology (In Press)
  • Peer Reviewed
• [Presentation] M6型A群レンサ球菌が産生する線毛形成機構と機能解析 (2010)
  • Author(s): 木村敬次リチャード, 住友倫子, 寺尾豊, 磯田竜太朗, 中田匡宣, 川端重忠
  • Organizer: 第63回日本細菌学会 関西支部総会
  • Place of Presentation: 枚方市
  • Year and Date: 2010-11-20
• [Presentation] Neonatal Exposure Induced Commensal-like Immune-response Against Aggregatibacter actinomycetemcomitans in Mice (2009)
  • Author(s): R.ISODA, Y.TERAO, M.NAKATA, T.SUMITOMO, S.KAWABATA
  • Organizer: 87^<th> International Association for Dental Research General Session
  • Place of Presentation: Miami, USA
  • Year and Date: 2009-04-04
• [Remarks]
  • URL: http://web.dent.osaka-u.ac.jp/~mcrbio/
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/~mcrbio/