Functional Anatomy of Descending Projections from the Cerebral Cortex Involved in Control of Mastication

• Project/Area Number: 20592138
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: YOSHIDA Atsushi Osaka University, 大学院・歯学研究科, 教授 (90201855)
• Co-Investigator(Kenkyū-buntansha): MORITANI Masayuki 森ノ宮医療大学, 保健医療学部, 教授 (80303981) ; ONO Takahiro 大阪大学, 大学院・歯学研究科, 准教授 (30204241)
• Co-Investigator(Renkei-kenkyūsha): TAKI Ikuro 大阪大学, 大学院・歯学研究科, RA (40467585)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳 / 神経 / 解剖 / 歯学 / 咀嚼 / 大脳皮質 / ラット / 神経トレーサー

Research Abstract

Three cortical areas (rostral part of the lateral agranular cortex [r-Agl], rostral part of the medial agranular cortex [r-Agm], rostral part of the primary somatosensory cortex [r-S1]) were found to project directly to the three groups of premotoneuron areas around the trigeminal motor nucleus in the rat. The r-Agl and r-Agm had stronger connections with the motor thalamus, while the r-S1 with the sensory thalamus. Electrical stimulation of the r-Agl and r-S1 induced different patterns of jaw movements, while that of the r-Agm induced no jaw movements. The present study indicated that the r-Agl, r-Agm and r-S1 play different roles in jaw movements.

Research Products

• [Journal Article] Corticofugal direct projections to primary afferent neurons in the trigeminal mesencephalic nucleus of rats. (2010)
  • Author(s): C Iida, A Oka, M Moritani, T Kato, T Haque, F Sato, M Nakamura, K Uchino, S Seki, Y-C Bae, K Takada, A Yoshida.
  • Journal Title: Neuroscience 169 Pages: 1739-1757
  • Peer Reviewed
• [Journal Article] Thalamic afferent and efferent connectivity to cerebral cortical areas with direct projections to identified subgroups of trigeminal premotoneurons in the rat. (2010)
  • Author(s): T Haque, S Yamamoto, Y Masuda, T Kato, F Sato, K Uchino, A Oka, M Nakamura, R Takeda, T Ono, M Kogo, A Yoshida.
  • Journal Title: Brain Res 1346 Pages: 69-82
  • Peer Reviewed
• [Journal Article] Thalamic afferent and efferent connectivity to cerebral cortical areas with direct projections to identified subgroups of trigeminal premotoneurons in the rat. (2010)
  • Author(s): T Haque, et al.
  • Journal Title: Brain Research Volume: 1346 Pages: 69-82
  • Peer Reviewed
• [Journal Article] Corticofugal direct projections to primary afferent neurons in the trigeminal mesencephalic nucleus of rats (2010)
  • Author(s): C Iida, et al.
  • Journal Title: Neuroscience Volume: 169 Pages: 1739-1757
  • Peer Reviewed
• [Journal Article] Distribution of premotoneurons for jaw-closing and jaw-opening motor nucleus receiving contacts from axon terminals of primary somatosensory cortical neurons in rats. (2009)
  • Author(s): Chang Z, Haque T, Iida C, Seki S, Sato F, Kato T, Uchino K, Ono T, Nakamura M, Bae Y-C, Yoshida A.
  • Journal Title: Brain Res 1275 Pages: 43-53
  • Peer Reviewed
• [Journal Article] Corticofugal projections to trigeminal motoneurons innervating antagonistic jaw muscles in rats as demonstrated by anterograde and retrograde tract-tracing. (2009)
  • Author(s): Yoshida, A., Taki, I., Chang, Z., Iida, C., Haque, T., Tomita, A., Seki, S., Yamamoto, S., Masuda, Y., Moritani, M., Shigenaga, Y.
  • Journal Title: J.Comp.Neurol. 514 Pages: 368-386
  • Peer Reviewed
• [Journal Article] Distribution of premotoneurons for jaw-closing and jaw-opening motor nucleus receiving contacts from axon terminals of primary somatosensory cortical neurons in rats (2009)
  • Author(s): Chang Z, et al.
  • Journal Title: Brain Research 1275 Pages: 43-53
  • Peer Reviewed
• [Journal Article] Light and electron microscopic analysis of the somata and parent axons innervating the rat upper molar and lower incisor pulp (2009)
  • Author(s): Paik SK, et al.
  • Journal Title: Neuroscience 162 Pages: 1279-1286
  • Peer Reviewed
• [Journal Article] Corticofugal projections to trigeminal motoneurons innervating antagonistic jaw muscles in rats as demonstrated by anterograde and retrogradetract-tracing. (2009)
  • Author(s): Yoshida, A, et al.
  • Journal Title: J. Comp. Neurol. (in press)
  • Peer Reviewed
• [Journal Article] GABA- and glycine-like immunoreactivity in axonal endings presynapti c to the vibrissa afferents in the cat trigeminal interpolar nucleus (2008)
  • Author(s): Moon YS., et al.
  • Journal Title: Neuroscience 152 Pages: 138-145
  • Peer Reviewed
• [Journal Article] Synaptic transmission from the supratrigeminal region to jaw-closing and jaw-opening motoneurons in developing rats. (2008)
  • Author(s): Nakamura S., et al.
  • Journal Title: J. Neurophysiol. 100 Pages: 1885-1896
  • Peer Reviewed
• [Presentation] Descending projections from the cerebral cortex to lower brainstem neurons involved in orofacial sensory and motor functions (2011)
  • Author(s): A Yoshida、T Kato
  • Organizer: 第116回日本解剖学会総会・全国学術集会 第88回日本生理学会大会 合同大会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 2011-03-28
• [Presentation] ラット大脳皮質一次体性感覚野ニューロンの三叉神経運動前ニューロンへの投射様態 (2009)
  • Author(s): 飯田千絵、岡綾香、佐藤文彦、山本雅章、武田理恵子、加藤隆史、吉田篤
  • Organizer: 日本解剖学会近畿支部学術集会
  • Place of Presentation: 奈良県立医科大学(橿原市)
  • Year and Date: 2009-11-28
• [Presentation] ラット三叉神経運動前ニューロン群に投射する大脳皮質部位と視床との神経連絡 (2009)
  • Author(s): 山本真也, 他
  • Organizer: 顎口腔機能学会
  • Place of Presentation: 昭和大学 (東京)
  • Year and Date: 2009-11-28
• [Presentation] Topographic Projections from Cortex to Trigeminal Premotoneurons in Rats. The promotion of multi-disciplinary research projects (2009)
  • Author(s): Yoshida A., et al.
  • Organizer: The promotion of multi-disciplinary research projects
  • Place of Presentation: Nihon University Schoolof Dentistry, Tokyo
  • Year and Date: 2009-02-21
• [Presentation] ラット三叉神経運動前ニューロン群に投射する大脳皮質部位と視床との神経連絡 (2009)
  • Author(s): 山本真也、加藤隆史、増田裕次、佐藤文彦、岡綾香、滝育郎、吉田篤
  • Organizer: 顎口腔機能学会
  • Place of Presentation: 昭和大学(東京)
• [Presentation] 三叉神経運動前ニューロン群に投射する大脳皮質と視床との神経連絡 (2009)
  • Author(s): Tahsinul Haque、山本真也、加藤隆史、増田裕次、佐藤文彦、岡綾香、滝育郎、吉田篤
  • Organizer: 三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 日本大学(軽井沢)
• [Presentation] 大脳皮質から閉口筋運動前ニューロンならびに開口筋運動前ニューロンへの投射 (2008)
  • Author(s): 滝育郎、磯貝文彦、関伸一郎、飯田千絵、富田章子、佐藤文彦、加藤隆史、増田裕次、吉田篤
  • Organizer: 三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 新潟大学(新潟)
  • Year and Date: 2008-12-07
• [Book] 口腔顔面領域の神経解剖学の最前線、生命歯科医学のカッティングエッジ(米田俊之編) (2008)
  • Author(s): 吉田篤、森谷正之、山本雅章、滝育郎、飯田千絵、富田章子、山本真也、Tahsin Haque、関伸一郎
  • Publisher: 大阪大学出版会
• [Book] 生命歯科医学のカッテ. インク・エッジ (米田俊之編) (2008)
  • Author(s): 吉田篤, 他
  • Total Pages: 287
  • Publisher: 大阪大学出版会
• [Remarks] ホームページ等
  • URL: http://www.dent.osaka-u.ac.jp/graduate/course/anat2.html
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/graduate/course/anat2.html
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/~anat2/