Histological and molecular biological study for standardization of pathological diagnosis of salivary gland tumors
| Project/Area Number |
20592141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OGAWA Ikuko Hiroshima University, 病院, 講師 (70136092)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA Takashi 広島大学, 医歯薬学総合研究科, 教授 (10154783)
KUDO Yasusei 広島大学, 医歯薬学総合研究科, 助教 (50314753)
MIYAUCHI Mutsumi 広島大学, 医歯薬学総合研究科, 准教授 (50169265)
KITAGAWA Masae 広島大学, 病院, 助教 (10403627)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 病理診断 / 唾液腺腫瘍 / 筋上皮マーカー / PLAG1 / 細胞増殖マーカー / 明細胞性腫瘍 / geminin / p63 / S100タンパク / 嚢胞腺腫 / 腺癌 / 腫瘍性筋上皮 / カルポニン / c-kit / Aurora B |
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| Research Abstract |
For establishment of objective diagnostic standards of salivary gland tumors, we analyzed the expression of various proteins and genes by histological, immunohistochemical and molecular pathological methods. The results indicated that the expression and localization of various myoepithelial markers, overexpression of PLAG1 protein in pleomorphic adenoma, MUC protein expression in acinic cell carcinoma and evaluation of cell proliferative markers including Ki-67 and geminin were useful for the differential diagnosis and the prediction of the prognosis. It was also clarified the relationship between overexpression of cell cycle related factors such as Aurora kinase and malignancy of the tumors.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and -unstained areas2010
Author(s)
Ohta K, Ogawa I, Ono S, Taki M, Mizuta K, Miyauchi M, Takechi M,, Shigeishi H, Takata T, Kamata N.
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Journal Title
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Peer Reviewed
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[Book] 口腔病変クローズアップ2010
Author(s)
小川郁子, 北川雅恵, 工藤保誠, 宮内睦美, 高田隆
Total Pages
143
Publisher
デンタルダイヤモンド社
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