Regulation mechanisms of development, growth and degeneration of craniofacial embryonic tissues.
| Project/Area Number |
20592146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
AMANO Osamu Meikai University, 歯学部, 教授 (60193025)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 発生 / 熱ショックタンパク / アポトーシス / メッケル軟骨 / 甲状舌管 / 歯肉 / 甲状腺 / 脂肪酸結合タンパク / 細胞増殖 / 軟骨吸収 / 骨端板軟骨 / 軟骨内骨化 / 熱ショック蛋白質 / Hsp27 / Hsp25 / 歯胚 |
|---|
| Research Abstract |
The following findings were obtained in the development and degenerative processes of mouse Meckel's cartilage : apoptosis was not found in Meckel's chondrocytes ; many apoptotic cells were found in the perichondrium of lateral growing aspect of the cartilage during the developing period ; and organ-cultured mouse embryonic mandibles supplemented with an apoptotic depressant showed partial deficiency of Meckel's cartilage. These results strongly suggested that the apoptosis is involved in the differentiation of chondroblasts in the perichondrim and is essential for the morphogenesis of Meckel's cartilage.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Non-apoptotic cell death induced by nutritional starvation in J774.1 mouse macrophage-like cell line.2009
Author(s)
Thet MM, Yokote Y, Chu Q, Wang QT, Kishino K, Tamura N, Shimada J, Amano O, Kanda Y, Kunii S, Takekawa F, Hatano H, Shimada C, Hasegawa H, Sakagami H
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Journal Title
Anticancer Res 29(12)
Pages: 5083-5088
Related Report
Peer Reviewed
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[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound.2008
Author(s)
Liu Y, Sakagami H, Hashimoto K, Kikuchi H, Amano O, Ishihara M, Kanda Y, Kunii S, Kochi M, Zhang W, Yu G
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Journal Title
Anticancer Res 28(1A)
Pages: 229-236
Related Report
Peer Reviewed
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[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.2008
Author(s)
Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H
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Journal Title
Anticancer Res 28(2A)
Pages: 1069-1078
NAID
Related Report
Peer Reviewed
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