Effect of PACAP on saliva secretion.

• Project/Area Number: 20592148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: NONAKA Naoko 昭和大学, 歯学部, 講師 (20307052)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Masanori 昭和大学, 歯学部, 教授 (50180394) ; SHIODA Seiji 昭和大学, 医学部, 教授 (80102375) ; NAKAMACHI Tomoya 昭和大学, 遺伝子組換え実験室, 助教 (30433840)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ドライマウス / 唾液腺 / PACAP / PACAPレセプター / 耳下腺 / 顎下腺 / 舌下腺 / シェーグレン / シェーグレンモデルマウス / PACAPレセブター

Research Abstract

The control of saliva secretion is mainly under the autonomic nervous control. Pituitary adenylate cyclase-activating polypeptide(PACAP) is now recognized as the multi-functional neuropeptide in various organs. We compared the distribution of PACAP and its receptor, PAC-1, in major salivary glands ; parotid, submandibular and sublingual glands, of young(8 weeks) and old(8 months) C57BL/6 mice.

Research Products

• [Journal Article] Distribution of neuropeptide W in the rat brain (2010)
  • Author(s): Takenoya F, Yagi M, Kageyama H, Shiba K, Endo K, Nonaka N, Date Y, Nakazato M, Shioda S
  • Journal Title: Neuropeptids Volume: 44 Pages: 99-106
• [Journal Article] Regional restriction of lymphoid follicles in the lymph node by the draining lymphatic vessels (2010)
  • Author(s): Sekine Y, Ohtsuka T, Yanagisawa Y, Sakagami J, Nonaka N, Namakura M
  • Journal Title: Dent Med Res Volume: 30 Pages: 124-128
  • NAID: 10027973045
  • Peer Reviewed
• [Journal Article] Permeability of the blood-brain barrier to a rhenacarborane (2009)
  • Author(s): Hawkins PM, Jelliss PA, Nonaka N, Shi X, Banks WA
  • Journal Title: J pharmacol Exp 329 Pages: 608-14
  • Peer Reviewed
• [Journal Article] Isolation of peptide transport system-6 brain endothelial cell : therapeutic effects with antisense inhibition in Alzheimer and and stroke models (2009)
  • Author(s): Dogrukol-Ak D, Kumar VB, Ryerse JS
  • Journal Title: J Cereb Blood Flow Metab. 29(2) Pages: 411-422
  • Peer Reviewed
• [Journal Article] Morphometric evaluation of the againg process in various himan nerve fibers (2008)
  • Author(s): Nonaka N, Goto N, Goto J, Shibata
  • Journal Title: Okajimas Folia Anat Jpn 85(3) Pages: 103-106
  • Peer Reviewed
• [Journal Article] Delivery of galanin-like peptide to the brain : targeting with intranasal delivery and cyclodextrins. (2008)
  • Author(s): Nonaka N, Farr SA, Kageyama H, Shi
  • Journal Title: J Pharmacol Exp Ther. 325(2) Pages: 513-519
  • Peer Reviewed
• [Presentation] Immunohistochemical comparison of the localization of PACAP and its receptor, PAC-1, in major salivary glands between young and old mice (2011)
  • Author(s): Naoko Nonaka, Tomoya Nakamach, Seiji Shioda, Masanori Nakamura
  • Organizer: The 116th Annual meeting of the Japanese Association of Anatomists
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-29
• [Presentation] Antiobesity effect by intranasal administration of GALP in mice (2011)
  • Author(s): Kanako Shiba, Haruki Kageyama, Naoko Nonaka, Fumiko Takenoya, Seiji Shioda
  • Organizer: The 116th Annual meeting of the Japanese Association of Anatomists
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-29
• [Presentation] マウスおよびヒト唾液腺におけるPACAPとPAC1Rの免疫組織化学的局在 (2011)
  • Author(s): 野中直子, 中村雅典
  • Organizer: 第65回日本人類学会大会抄録集,第65回日本人類学会大会
  • Place of Presentation: 沖縄
• [Presentation] Immunohistochemical localizations of pituitary adenylate cyclase-activating polypeptide(PACAP) and its receptor(PAC1R) in mouse major salivary glands (2011)
  • Author(s): Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
  • Organizer: 第10回日中合同組織細胞化学セミナー
  • Place of Presentation: 北京
• [Presentation] マウス唾液腺におけるPACAPレセプターの局在とPACAPの唾液分泌への効果 (2011)
  • Author(s): 野中直子, 中村雅典
  • Organizer: 第53回歯科基礎医学会学術大会抄録集,第53回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 岐阜
• [Presentation] マウス唾液腺におけるPACAPレセプターおよびVIPレセプターの免疫組織化学的局在と唾液分泌への効果 (2011)
  • Author(s): 野中直子, 中町智哉, 塩田清二, 中村雅典
  • Organizer: 第52回日本組織細胞化学会総会・学術集会予稿集,第52回日本組織細胞化学会
  • Place of Presentation: 金沢
• [Presentation] マウス唾液腺におけるPACAPレセプターの局在とPACAP経鼻投与による唾液分泌量の亢進 (2011)
  • Author(s): 野中直子, 中町智哉, 塩田清二, 中村雅典
  • Organizer: 第11回日本抗加齢学会総会抄録集,第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] Immunohistochemical localization of pituitary adenylate cyclase-activating polypeptide(PACAP) and its receptor(PAC-1) in mouse major salivary glands (2011)
  • Author(s): Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
  • Organizer: AAA Annual Meeting at Experimental Biology 2011
  • Place of Presentation: Washington DC
• [Presentation] Immunohistochemical comparison of the localization of PACAP and its receptor, PAC-1, in major salivary glands between young and old mice (2011)
  • Author(s): Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
  • Organizer: The Journal of Physiological Sciences Volume61, Supplement 1, 2011 S223, The 116^<th> Annual meeting of the Japanese Association of Anatomists
  • Place of Presentation: Yokohama
• [Presentation] マウス唾液腺におけるPACAP, PAC-1レセプターの免疫組織化学的研究 (2010)
  • Author(s): 野中直子, 中町智哉, 塩田清二, 中村雅典
  • Organizer: 第51回日本組織細胞化学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-04
• [Presentation] Immunohistochemical localization of PACAP and PAC-1 receptors in mouse salivary glands (2010)
  • Author(s): Naoko Nonaka, Tomoya Nakamach, Seiji Shioda, Masanori Nakamura
  • Organizer: 第10回日本抗加齢学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-12
• [Presentation] Immunohistchemical localization of PACAP and PAC-1 receptors in mouse salivary glands (2010)
  • Author(s): 野中直子, 中町智也, 塩田清二, 中村雅典
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手医科大学
• [Presentation] ヒトのニューロン細胞体の分類:形態計測・機能の相関 (2010)
  • Author(s): 後藤潤, 後藤昇, 柴田昌和, 野中直子, 中村雅典, 土谷邦秋, 塩田清二
  • Organizer: 第115回日本解剖学会
  • Place of Presentation: 岩手医科大学
• [Presentation] ガラニン様ペプチドの点鼻投法による脳移行解析 (2009)
  • Author(s): 竹ノ内 文子, 影山 晴秋, 野中
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山(岡山理科大学)
  • Year and Date: 2009-03-30
• [Presentation] 神経軸索の計測法の比較 (2009)
  • Author(s): 柴田 昌和, 後藤 昇, 後藤 潤
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山(岡山理科大学)
  • Year and Date: 2009-03-30
• [Presentation] 内因性PACAPによる虚血性神経細胞死制御作用の解析 (2009)
  • Author(s): 中町 智哉, 大滝 博和, 養父 佐
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山(岡山理科大学)
  • Year and Date: 2009-03-28
• [Presentation] Delivery of galanin-like peptide to the brain (2009)
  • Author(s): 野中直子
  • Organizer: 8th Cerebral vascular Biology International Conference
  • Place of Presentation: 仙台
• [Presentation] Delivery of Pituitary adenylate cyclase activating polypetide(PACAP)to the brain : targeting with intranasal delivery and cyclodextrins (2009)
  • Author(s): Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, William A Banks
  • Organizer: The 9th International Symposium on VIP, PACAP
  • Place of Presentation: 鹿児島
• [Presentation] 上顎神経と下顎神経の加齢変化 (2008)
  • Author(s): 野中 直子, 後藤 昇, 柴田 昌和
  • Organizer: 第62回 日本人類学会
  • Place of Presentation: 名古屋(愛知学院大学)
  • Year and Date: 2008-11-01