| Project/Area Number |
20592148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
|
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| Research Institution | Showa University |
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Principal Investigator |
NONAKA Naoko 昭和大学, 歯学部, 講師 (20307052)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Masanori 昭和大学, 歯学部, 教授 (50180394)
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
NAKAMACHI Tomoya 昭和大学, 遺伝子組換え実験室, 助教 (30433840)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ドライマウス / 唾液腺 / PACAP / PACAPレセプター / 耳下腺 / 顎下腺 / 舌下腺 / シェーグレン / シェーグレンモデルマウス / PACAPレセブター |
|---|
| Research Abstract |
The control of saliva secretion is mainly under the autonomic nervous control. Pituitary adenylate cyclase-activating polypeptide(PACAP) is now recognized as the multi-functional neuropeptide in various organs. We compared the distribution of PACAP and its receptor, PAC-1, in major salivary glands ; parotid, submandibular and sublingual glands, of young(8 weeks) and old(8 months) C57BL/6 mice.
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