Clinical application of novel osteoinductive protein (NELL1)

• Project/Area Number: 20592149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: ODA Mitsuo Showa University, 歯学部, 兼任講師 (30359492)
• Co-Investigator(Renkei-kenkyūsha): KURODA Syunichi 名古屋大学, 生命農学研究科, 教授 (60263406) ; NAKAMURA Masanori 昭和大学, 歯学部, 教授 (50180394) ; MAYAHARA Mitsuori 昭和大学, 歯学部, 助教 (30384184)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 新規骨形成タンパク / NELL1 / 軟骨形成 / 骨形成タンパク質 / 骨誘導能 / 軟骨 / 骨形成 / 骨折 / 移植・再生医療 / 再生医学 / 生体機能利用 / 発生・分化 / 歯学

Research Abstract

NELL1,which was cloned in 1996(Watanabe)1999(Kuroda)、induces osteogenesis in vivo though its optimal condition for osteogenesis was not clarified. However NELL1 showed prominent cartilage inducing capacity under certain conditions.

Research Products

• [Presentation] 骨形成因子(BMP)による骨造成を想定した実験的研究(会議録) (2011)
  • Author(s): 成田憲司,織田光夫,馬谷原光織,中川祥,久保田耕世,榊宏剛,佐藤寿,小林恒,片岡竜太,中村雅典,木村博人
  • Organizer: 日本口腔科学会雑誌(0029-0297)(60巻1号 Page130)
• [Patent(Industrial Property Rights)] Technique for heterotropic regeneration and control of tissues and organs by using nell-1 (2011)
  • Inventor(s): 織田光夫,馬谷原光織,中村雅典
  • Industrial Property Rights Holder: 織田光夫,馬谷原光織,中村雅典
  • Filing Date: 2011
• [Patent(Industrial Property Rights)] TECHNIQUE FOR REGULATING REGENERATION OF TISSUE OR FAULTY OR ABNORMAL PART IN ORGAN USING NELL-1 (2010)
  • Inventor(s): NAKAMURA Masanori, NAKAMURA Masanori, KURODA Shunichi, ODA Mitsuo, MAYAHARA Mitsuori, KENMOTSU Sachiyo, IGARASHI Koichi, OIE Kazunori
  • Filing Date: 2010-11-02
• [Patent(Industrial Property Rights)] MEDICINE AND MEDICAL INSTRUMENT CONTAINING OSTEOGENIC AND CHONDROGENIC PROTEIN (2009)
  • Inventor(s): NAKAMURA Masanori, KURODA Shun'ichi, KAKU Junichiro, ODA Mitsuo, MAYAHARA Mitsuori, KENMOTSU Sachiyo, BOKUI Nobuyuki, IGARASHI Koichi
  • Filing Date: 2009-07-05
• [Patent(Industrial Property Rights)] Technique for heterotropic regeneration and control of tissues and organs by using nell-1 (2009)
  • Inventor(s): 織田光夫, 他
  • Industrial Property Rights Holder: 織田光夫, 他
  • Filing Date: 2009-08-03
  • Overseas
• [Patent(Industrial Property Rights)] NELL1による組織・臓器再生制御技術 (2009)
  • Inventor(s): 中村雅典, 織田光夫, 他
  • Industrial Property Rights Holder: 中村雅典, 織田光夫, 他
  • Filing Date: 2009
  • Overseas
• [Patent(Industrial Property Rights)] NELL1による組織・臓器再生制御技術 (2008)
  • Inventor(s): 中村雅典, 織田光夫, 他
  • Industrial Property Rights Holder: 昭和大学, 大阪大学, 片山化学工業
  • Industrial Property Number: 2008-201346
  • Filing Date: 2008
• [Patent(Industrial Property Rights)] 新規骨誘導および軟骨誘導タンパク質を含有する医薬品および医療機器 (2008)
  • Inventor(s): 中村雅典, 織田光夫, 他
  • Industrial Property Rights Holder: 昭和大学, 大阪大学, 片山化学工業
  • Acquisition Date: 2008
  • Overseas