| Project/Area Number |
20592153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
YAMAMOTO Hitoshi Nihon University, 松戸歯学部, 講師 (80265165)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Rumi 日本大学, 松戸歯学部, 助手 (30312044)
SUZUKI Kunihiro 日本大学, 松戸歯学部, 教授 (30256903)
KOZAWA Yukishige 日本大学, 松戸歯学部, 教授 (80014132)
MURAMATSU Takashi 東京歯科大学, 歯学部, 講師 (00276982)
新美 寿英 日本大学, 松戸歯学部, 助手 (70508754)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯根 / 多根歯 / 歯 / 再生 / 多根化 / 形態形成 / 上皮-間葉相互作用 / 発生 / 多根 / 象牙質根間突起 / 上皮性根間突起 / 髄下葉 / Hertwig上皮鞘 / マウス / ラット |
|---|
| Research Abstract |
Multi-root formation consists of both epithelial projection and subpulpal lobe formation. The process of the multi-root formation was examined by in situ hybridization, immunohistochemistry and hematoxyline staining in mice and rats. As a result, it is considerable that a specific genetic cascade controlled epithelial projection during multi-root formation. Moreover, subpulpal lobes are formed island-like and cell differentiation during subpulpal lobe formation is similar to that of tooth crown dentin formation.
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