• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Tooth root morphogenesis ? molecular and morphological analysis for multi-root formation

Research Project

Project/Area Number 20592153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNihon University

Principal Investigator

YAMAMOTO Hitoshi  Nihon University, 松戸歯学部, 講師 (80265165)

Co-Investigator(Kenkyū-buntansha) OHTA Rumi  日本大学, 松戸歯学部, 助手 (30312044)
SUZUKI Kunihiro  日本大学, 松戸歯学部, 教授 (30256903)
KOZAWA Yukishige  日本大学, 松戸歯学部, 教授 (80014132)
MURAMATSU Takashi  東京歯科大学, 歯学部, 講師 (00276982)
新美 寿英  日本大学, 松戸歯学部, 助手 (70508754)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords歯根 / 多根歯 / 歯 / 再生 / 多根化 / 形態形成 / 上皮-間葉相互作用 / 発生 / 多根 / 象牙質根間突起 / 上皮性根間突起 / 髄下葉 / Hertwig上皮鞘 / マウス / ラット
Research Abstract

Multi-root formation consists of both epithelial projection and subpulpal lobe formation. The process of the multi-root formation was examined by in situ hybridization, immunohistochemistry and hematoxyline staining in mice and rats. As a result, it is considerable that a specific genetic cascade controlled epithelial projection during multi-root formation. Moreover, subpulpal lobes are formed island-like and cell differentiation during subpulpal lobe formation is similar to that of tooth crown dentin formation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (53 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (35 results) Book (2 results)

  • [Journal Article] Alteration of cytokeratin expression during palatine rugae development in mice2011

    • Author(s)
      Yamamoto H、Muramastu T、Shibukawa Y、Sohn WJ、 Kim JY、Tazaki M
    • Journal Title

      Journal of Hard Tissue Biology 20巻

      Pages: 17-22

    • NAID

      130004848359

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional orientation of human enamel crystallites using x-ray diffraction2011

    • Author(s)
      Sakae T、Hirayama K、Yamamoto H、Suzuki K、Hayakawa Y、Takahashi Y、Kuwada T、Nakao K、Nogami K、Inagaki M、Tanaka T、Hayakawa K、Sato I、Kakei M
    • Journal Title

      Journal of Hard Tissue Biology 20巻

      Pages: 7-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional orientation analysis of human enamel crystallites using x-ray diffraction2011

    • Author(s)
      Sakae T, Yamamoto H, 他
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20 Pages: 7-10

    • NAID

      130004848366

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of the cytokeratin expression during palatine rugae development in mice2011

    • Author(s)
      Yamamoto H, 他
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20 Pages: 17-22

    • NAID

      130004848359

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray phase-contrast imaging and x-ray absorption fine structure analysis using parametric x-ray radiation generated at LEBRA, Nihon University2010

    • Author(s)
      Sakae T、Hayakawa Y、Takahashi Y、Tanaka T、Hayakawa K、Kuwada T、Nakao K、Nogami K、Inagaki M、Yamamoto H、Iwata N、Suzuki K、 Mori A、Tanimoto Y、Hayakawa T、Nakada H、Suwa T、Numata Y、Suemitsu M、Sato Y、Okada H、Yamamoto H、Sekiya K、Kaneda T、Nishimura H、Kitamura H、Hata S、Akimoto Y、Suzuki K、Yamamoto H、Shintomi T、Sato I
    • Journal Title

      International Journal of Oral-Medical Sciences 9巻

      Pages: 122-136

    • NAID

      130000417581

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulated genes in mouse dental papillae and pulp2010

    • Author(s)
      Sasaki H、Muramatsu T、Kwon HJ、Yamamoto H、Hashimito S、Jung HS、Shimono M
    • Journal Title

      Journal of Dental Research 89巻

      Pages: 679-683

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down regulated genes in mouse dental papillae and pulp2010

    • Author(s)
      Sasaki H, Yamamoto H, 他
    • Journal Title

      Journal of Dental Research

      Volume: 89 Pages: 679-683

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray phase-contrast imaging and x-ray absorption fine structure analysis using parametric x-ray radiation generated at LEBRA, Nihon University2010

    • Author(s)
      Sakae T, Yamamoto H, 他
    • Journal Title

      International Journal of Oral-Medical Sciences

      Volume: 9 Pages: 122-136

    • NAID

      130000417581

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal tissue formation by reaggregation system in mice2009

    • Author(s)
      Yamamoto H、Cai JL、Cho SW、Kim JY、Jung HS
    • Journal Title

      Journal of Hard Tissue Biology 18巻

      Pages: 77-82

    • NAID

      10025927768

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal tissue formation by reaggregation system in mice2009

    • Author(s)
      Hitoshi Yamamoto
    • Journal Title

      Journal of Hard Tissue Biology 18

      Pages: 77-82

    • NAID

      10025927768

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Properties of cells at the palatine rugae during palate development in mice2008

    • Author(s)
      Yamamoto H、Muramatsu T、Shibukawa Y、Tazaki M
    • Journal Title

      Proceedings of International Conference on Frontier of Dental and Craniofacial Research

      Pages: 28-29

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three dimensional observation of the enamel prism of Subhyracodon Molars2008

    • Author(s)
      Suzuki K、Sakae T、Yamamoto H、Kozawa Y
    • Journal Title

      International Journal of Oral-Medical Sciences 7巻

      Pages: 113-118

    • NAID

      130000411423

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the structure of tooth germs transplanted into the subcutaneous tissue or the kidney capsule of mice2008

    • Author(s)
      Higuchi H、Yamamoto H、Cai JL、Suzuki K、Jung HS、Kozawa Y
    • Journal Title

      International Journal of Oral-Medical Sciences 7巻

      Pages: 37-34

    • NAID

      130000411390

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the structures of tooth germs transplanted into the subcutaneous tissue or the kidney capsule of mice2008

    • Author(s)
      Yuka Higuchi, Hitoshi Yamamoto, 他4名
    • Journal Title

      International Journal of Oral-MedicalSciences 7(1)

      Pages: 27-34

    • NAID

      130000411390

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional Observation of the enamel prisms of Subhyracodon Molars2008

    • Author(s)
      Kunihiro Suzuki, Toshiro Sakae, Hitoshi Yamamoto, 他1名
    • Journal Title

      International Journal of Oral-Medical Sciences 7(2)

      Pages: 113-118

    • NAID

      130000411423

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Properties of cells at the palatine rugae during palatedevelopment in mice2008

    • Author(s)
      Hitoshi Yamamoto, 他3名
    • Journal Title

      Proceedings of International Conference on Frontier of Dental and Craniofacial Research

      Pages: 28-29

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] X-ray phase contrast imaging of dental tissue2010

    • Author(s)
      Sakae T、Okada H、Nakada H、Suzuki K、Yamamoto H
    • Organizer
      The 58th Annual meeting of Japanese Association for Dental Research
    • Place of Presentation
      小倉(九州歯科大学)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] X-ray phase contrast imaging of dental tissue2010

    • Author(s)
      Sakae T, Yamamoto H, 他
    • Organizer
      The 58^<th> Annual meeting of Japanese Association for Dental Research
    • Place of Presentation
      小倉(九州歯科大学)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 象牙芽細胞のGrouping and Dancingと象牙質の構造2010

    • Author(s)
      太田(横田)ルミ、新美寿英、山本仁、鈴木久仁博、小澤幸重
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      東京(タワーホール船堀)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒト・エナメル質結晶のX線回折法による3次元配向解析2010

    • Author(s)
      寒河江登志朗、鈴木久仁博、山本仁
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      東京(タワーホール船堀)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Observation on the reproduction of gray short-tailed opossum (Monodelphis domestica)2010

    • Author(s)
      鈴木久仁博、寒河江登志朗、山本仁、太田ルミ、小澤幸重
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      東京(タワーホール船堀)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Observation on the reproduction of the gray short-tailed opossum (Monodelphis domestica)2010

    • Author(s)
      鈴木久仁博, 山本仁, 他
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      東京(タワーホール船堀)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス歯胚を用いた歯と歯周組織の再生に関する研究2010

    • Author(s)
      山本仁、〓晟愿、鈴木久仁博、寒河江登志朗、金宰瑩、鄭翰聖
    • Organizer
      第19回硬組織発生生物学会学術大会
    • Place of Presentation
      岡山(就実大学)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒト永久歯の無細胞セメント質と細胞セメント質の分布に関する研究2009

    • Author(s)
      山本仁、新美寿英、太田ルミ(横田ルミ)、鈴木久仁博、寒河江登志朗、小澤幸重
    • Organizer
      第18回硬組織発生生物学会
    • Place of Presentation
      札幌(北海道医療大学)
    • Year and Date
      2009-09-05
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト永久歯の無細胞セメント質と細胞セメント質の分布に関する研究2009

    • Author(s)
      山本仁
    • Organizer
      第18回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      北海道医療大学札幌サテライトキャンパス(北海道)
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 横口蓋ヒダの有無による口蓋粘膜構造の違いについて2009

    • Author(s)
      山本仁、新美寿英、太田ルミ、鈴木久仁博、寒河江登志朗、小澤幸重
    • Organizer
      第114回日本解剖学会学術集会
    • Place of Presentation
      岡山(岡山理科大学)
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 横口蓋ヒダの有無による口蓋粘膜構造の違いについて2009

    • Author(s)
      山本 仁, 他5名
    • Organizer
      第114回日本解剖学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] ハイイロネズミオポッサム(Monodelphis domestica)臼歯咬頭形成につて2009

    • Author(s)
      鈴木久仁博、山本 仁、寒河江登志朗、太田ルミ、新美寿英、小澤幸重
    • Organizer
      第114回日本解剖学会学術集会
    • Place of Presentation
      岡山(岡山理科大学)
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯の起源に関する比較解剖学的検討-角質歯から真歯へ2009

    • Author(s)
      小澤幸重、細川貴孝、新美寿英、太田ルミ、山本 仁、鈴木久仁博
    • Organizer
      第114回日本解剖学会学術集会
    • Place of Presentation
      岡山(岡山理科大学)
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯の起源に関する比較解剖学的検討-角質歯から真歯へ-2009

    • Author(s)
      小澤幸重, 細川貴孝, 新美寿英, 太田ルミ, 山本 仁, 他2名
    • Organizer
      第114回日本解剖学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ハイイロジネズミオポッサム(Monodelphis domestica )臼歯の咬頭形成について2009

    • Author(s)
      鈴木久仁博, 山本 仁, 他4名
    • Organizer
      第114回日本解剖学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 縦型ハンター・シュレーゲルの条紋について-サイ類臼歯の場合-2009

    • Author(s)
      鈴木久仁博、山本 仁、寒河江登志朗、新美寿英、太田ルミ、小澤幸重
    • Organizer
      日本古生物学会第158回例会
    • Place of Presentation
      那覇(琉球大学)
    • Year and Date
      2009-01-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 縦型ハンター・シュレーゲルの条紋について-サイ類臼歯の場合-2009

    • Author(s)
      鈴木久仁博, 山本 仁, 他4名
    • Organizer
      日本古生物学会第158回例会
    • Place of Presentation
      那覇
    • Year and Date
      2009-01-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Properties of cells at the palatine rugae during palate development in mice2008

    • Author(s)
      Yamamoto H、Muramatsu T、Shibukawa Y、Tazaki M
    • Organizer
      International Congress on Frontiers of Dental and Craniofacial Research
    • Place of Presentation
      中国(北京)
    • Year and Date
      2008-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Properties of cells at the palatine rugae during palate development in mice2008

    • Author(s)
      Hitoshi Yamamoto, 他3名
    • Organizer
      International Congress on Frontiers of Dentaland Craniofacial Research
    • Place of Presentation
      北京(中華民国)
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス横口蓋ヒダ形成時に一過性に出現する細胞群について2008

    • Author(s)
      山本仁、村松敬、澁川義幸、新美寿英、太田ルミ、鈴木久仁博、寒河江登志朗、田崎雅和、小澤幸重
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京(有明コンベンションホール)
    • Year and Date
      2008-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト歯根形態形成分化の比較解剖学的な分析2008

    • Author(s)
      小澤幸重、大島勇人、新美寿英、太田ルミ、山本仁、鈴木久仁博
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京(有明コンベンションホール)
    • Year and Date
      2008-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト歯根形態形成分化の比較解剖学的な分析2008

    • Author(s)
      小澤幸重, 大島勇人, 新美寿英, 太田, 横田ルミ, 山本 仁. 鈴木久仁博
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス横口蓋ヒダ形成時に-過性に出現する細胞群について2008

    • Author(s)
      山本 仁, 他8名
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 胎児混合歯列弓のマイクロシーティー(μCT)と三次元復元による観察2008

    • Author(s)
      大澤枝理、山口茜、太田ルミ、山本仁、鈴木久仁博、小澤幸重
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京(有明コンベンションホール)
    • Year and Date
      2008-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト下顎切歯のエナメル・象牙境の観察2008

    • Author(s)
      新美寿英、太田ルミ、山本仁、鈴木久仁博、寒河江登志朗、山下靖雄、小澤幸重
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京(有明コンベンションホール)
    • Year and Date
      2008-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 縦型シュレーゲル条の形成について-SubhyracodonとPyrotheriumの臼歯の場合2008

    • Author(s)
      鈴木久仁博、小澤幸重、寒河江登志朗、山本仁、太田ルミ、新美寿英
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京(有明コンベンションホール)
    • Year and Date
      2008-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] エナメル芽細胞のTorsional Mortion2008

    • Author(s)
      太田ルミ、新美寿英、山本仁、鈴木久仁博、寒河江登志朗、小澤幸重
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京(有明コンベンションホール)
    • Year and Date
      2008-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] エナメル芽細胞の細動Torsional Mortion2008

    • Author(s)
      太田ルミ(横田ルミ), 新美寿英, 山本 仁, 他3名
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 縦型シュレーゲル条の形成について-SubhyracodonとPyrotheriumの臼歯の場合2008

    • Author(s)
      鈴木久仁博, 小輝幸重, 寒河江登志朗, 山本 仁, 他2名
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト下顎切歯のエナメル・象牙境の観察2008

    • Author(s)
      新美寿英, 太田ルミ, 山本仁, 他4名
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 胎児混合歯列弓のマイクロシーディー(μCT)と三次元復元による観察2008

    • Author(s)
      大澤枝里, 山口 茜, 太田ルミ(横田)ルミ, 山本 仁, 他2名
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 根未完成歯移植後の歯根形態について-臨床的および実験的観察2008

    • Author(s)
      山本仁、大久保厚司
    • Organizer
      第6回日本再生歯科医学会学術大会
    • Place of Presentation
      東京(日本歯科大学)
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 根未完成歯移植後の歯根形態について-臨床的および実験的観察2008

    • Author(s)
      山本 仁, 大久保厚司
    • Organizer
      第6回日本再生歯科医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスの口蓋発生に関する研究 I.横口蓋ヒダの形成について2008

    • Author(s)
      山本仁、新美寿英、太田ルミ、鈴木久仁博、寒河江登志朗、小澤幸重
    • Organizer
      日本大学口腔科学会第8回学術大会
    • Place of Presentation
      千葉(日本大学松戸歯学部)
    • Year and Date
      2008-09-07
    • Related Report
      2010 Final Research Report
  • [Presentation] マウスの口蓋発生に関する研究 I. 横口蓋ヒダの形成について2008

    • Author(s)
      山本 仁, 他5名
    • Organizer
      第8回日本大学口腔科学会
    • Place of Presentation
      松戸
    • Year and Date
      2008-09-07
    • Related Report
      2008 Annual Research Report
  • [Book] エナメル質 形成、構造、遺伝、起源と進化2009

    • Author(s)
      山本仁, 他
    • Total Pages
      285
    • Publisher
      わかば出版
    • Related Report
      2010 Final Research Report
  • [Book] エナメル質 形成、構造、遺伝、再生、起源と進化2009

    • Author(s)
      山本仁
    • Total Pages
      285
    • Publisher
      わかば出版
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi