Elucidation of the disease molecules in oral lichen planus using proteome analysis.
| Project/Area Number |
20592155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
KOMIYAMA Kazuo Nihon University, 歯学部, 教授 (00120452)
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| Co-Investigator(Renkei-kenkyūsha) |
ESUMI Mariko 日本大学, 医学部, 准教授 (30167291)
ABIKO Munemitu 日本大学, 松戸歯学部, 教授 (70050086)
MUKAE Shotaro 日本大学, 歯学部, 専修医 (70553105)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 口腔扁平苔癬 / プロテオーム解析 / Cytokeratin 13 / Cytokeratin 17 / 樹状細胞 / プロテオーム / gene tip / LCM / keratin 13 / keratin 17 / CCR7 / プロスタグランジンE2 / Fascin |
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| Research Abstract |
To clarify the disease status of an intractable lesion of oral mucosa, such as oral lichen planus, we have employed the LC-MS/MS analysis. 92 proteins of specific for the oral lichen planus have detected. The data compared with epithelial dysplasia, carcinoma in situ and carcinoma of oral mucosa. We have found different expression pattern of cytokeratins, which is decreased CK13 expression in the oral lichen planus and carcinoma in situ as well as disappearance in the invasive carcinoma. However, CK17 expression increased in a course of progression of the epithelial dysplasia and atypia. This contradict expression pattern of CK is usefulness for the differential diagnosis in these malignant borderline lesions.
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Report
(4 results)
Research Products
(30 results)
