| Project/Area Number |
20592159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
KIKUCHI Kenichiro The Nippon Dental University, 生命歯学部, 准教授 (80267260)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Rie 日本歯科大学東京短期大学, 歯科衛生学科, 教授 (50168150)
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| Research Collaborator |
HAND Arthur R. University of Connecticut Health Center, Dept. of Craniofacial Sciences, Professor
SATO Sumie 日本歯科大学, 生命歯学部, 職員
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 顎下腺 / 舌下腺 / 老化 / 蛋白質 / 細胞・組織 / 発生・分化 / 歯学 / 組織・組織 |
|---|
| Research Abstract |
This study was designed to examine age-related expression mechanism and identification of protein in the sublingual and submandibular gland of male Wistar rats from 6 to 24 months. After 18 months, amyloid protein accumulates in the intralobular connective tissue surrounding the terminal portions and to the interlobular connective tissue around the blood vessels and the excretory ducts. A part of the serous and mucous cells of the sublingual and submandibular gland gradually was increased expresse of some protein with aging.
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