Analysis of expression mechanism and identification of protein in the salivary gland with aging.

Research Project

Project/Area Number	20592159
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Morphological basic dentistry
Research Institution	The Nippon Dental University
Principal Investigator	KIKUCHI Kenichiro The Nippon Dental University, 生命歯学部, 准教授 (80267260)
Co-Investigator(Renkei-kenkyūsha)	IKEDA Rie 日本歯科大学東京短期大学, 歯科衛生学科, 教授 (50168150)
Research Collaborator	HAND Arthur R. University of Connecticut Health Center, Dept. of Craniofacial Sciences, Professor SATO Sumie 日本歯科大学, 生命歯学部, 職員
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	顎下腺 / 舌下腺 / 老化 / 蛋白質 / 細胞・組織 / 発生・分化 / 歯学 / 組織・組織
Research Abstract	This study was designed to examine age-related expression mechanism and identification of protein in the sublingual and submandibular gland of male Wistar rats from 6 to 24 months. After 18 months, amyloid protein accumulates in the intralobular connective tissue surrounding the terminal portions and to the interlobular connective tissue around the blood vessels and the excretory ducts. A part of the serous and mucous cells of the sublingual and submandibular gland gradually was increased expresse of some protein with aging.