Protective effect of SOD on reactive oxygen species-induced salivary gland dysfunction.

Research Project

Project/Area Number	20592161
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Morphological basic dentistry
Research Institution	Tsurumi University
Principal Investigator	YAMADA Hiroyuki Tsurumi University, 歯学部, 講師 (90267542)
Co-Investigator(Kenkyū-buntansha)	SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634) MISHIMA Kenji 鶴見大学, 歯学部, 准教授 (50275343) INOUE Hiroko 鶴見大学, 歯学部, 講師 (50367306) 小原久実鶴見大学, 歯学部, 助教 (70454163)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	活性酸素 / SOD
Research Abstract	Superoxide dismutase (SOD) is an antioxidant enzyme that eliminates one of reactive oxygen species (ROS) of superoxide. In this study, we examined the ability of SOD to restore ROS-induced salivary gland dysfunction. Our results suggested that SOD may protect against salivary gland dysfunction induced by ROS, presumably by rapidly converting superoxide to hydrogen peroxide.

Report

(4 results)