Evaluation of stemness on salivary gland side population cells
| Project/Area Number |
20592162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
MISHIMA Kenji Tsurumi University, 歯学部, 准教授 (50275343)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
INOUE Hiroko 鶴見大学, 歯学部, 講師 (50367306)
YAMADA Hiroyuki 鶴見大学, 歯学部, 講師 (90267542)
小原 久実 鶴見大学, 歯学部, 助教 (70454163)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | SP細胞 / 幹細胞活性 / 唾液腺 / 上皮系幹細胞 / 損傷モデル / Thymidine kinase / LRC |
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| Research Abstract |
We examined whether SP cells isolated from mouse salivary glands possess stem cell activity or not. Consequently, it was clarified that SP cells had no characteristics of stem cell, such as quiescence and potential of reconstituting glands. In addition, by analysis of their surface marker antigens, SP cells derived from salivary glands, which we had expected as a salivary epithelial cell lineage, were determined to be a mesenchymal cell lineage.
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Report
(4 results)
Research Products
(9 results)
