| Project/Area Number |
20592163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
NINOMIYA Tadashi Matsumoto Dental University, 総合歯科医学研究所, 講師 (00360222)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroaki 松本歯科大学, 歯学部, 教授 (50227930)
HIRAGA Toru 松本歯科大学, 歯学部, 准教授 (70322170)
KOIDE Masanori 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 硬組織形成 / Side Population細胞 / 歯根膜細胞 / 微小環境 / SP細胞 / 幹細胞 / 歯周組織再生 |
|---|
| Research Abstract |
To elucidate the micro environment of stem cell in alveolar bone formation, we examined osteogenic potential of side population (SP) cell which contain abundantly the stem cells, in PDL cells. Isolated SP cells from rat PDL cells had high potential in differentiation into osteoblasts and formation of calcified matrices, compared with non-SP (NSP) cells. The gene expressions of osteoblast markers and BMP-2 in SP cells were higher level than that in NSP cells. On the other hand, the gene expressions of mineralization inhibitors such as periodontal ligament-associated protein-1 were high level in NSP cells. This study indicates that SP cells in PDL have high abilities to form bone-like matrices and are effective in regeneration of alveolar bone.
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