Basic research of the antigen delivery system that it aimed at the optimization of the DNA vaccine for cancer prevention
| Project/Area Number |
20592166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
MAEDA Hatsuhiko Aichi Gakuin University, 歯学部, 教授 (30175591)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Katsutoshi 愛知学院大学, 歯学部, 准教授 (60329604)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | DNAワクチン / パピローマウイルス / ナノスフェアー / ドラッグデリバリー / 癌抑制効果 / 口腔 / 扁平上皮癌 / naked pDNA / ハムスター / DNA ワクチン |
|---|
| Research Abstract |
Many oral mucous diseases are related to human papillomavirus (HPV). Recently it has become clear that more potent methods for DNA vaccine delivery need to be developed to enhance the efficacy of DNA vaccines. In this study, the best antigen delivery system was examined for the purpose of preventing HPV infection by using the DNA vaccine. The results showed that the immunization with PLGA nanosphere DNA vaccines followed by EP in vivo delayed carcinoma development of papillomavirus-associated oral cancer. Both of in vivo electroporation and PLGA nanosphere are potent methods for DNA vaccine delivery, therefore, it contributes to the papillomavirus-induced oral cancer prevention.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Human papillomaviruses in oral carcinoma and oral potentially malignant disorders : a systematic review.2011
Author(s)
S Syrjanen, G Lodi, I von Bultzingslowen, A Aliko, P Arduino, G Campisi, S Challacombe, G Ficarra, C Flaitz, HM Zhou, H Maeda, C Miller, M Jontell
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Journal Title
Oral Dieseases 17(Suppl.1)
Pages: 58-72
Related Report
Peer Reviewed
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[Presentation] Enhancement of DNA Vaccine Potency by In Vivo Electroporation2010
Author(s)
Maeda H, Yoshida W, Kubo K, Sugita Y, Sato E, Suzumura Y, Torii R, Wada A, Komatsu S, Ito K, Saito T, Umebayashi T, Jinno M, Takayama M, Honda Y
Organizer
10^<th> Biannial Conference, European Association of Oral Medicine
Place of Presentation
London, UK
Year and Date
2010-09-24
Related Report
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[Presentation] Enhancement of DNA Vaccine Potency by In Vivo Electroporation.2010
Author(s)
Maeda H, Yoshida W, Kubo K, Sugita Y, Sato E, Suzumura Y, Torii R, Wada A, Komatsu S, Ito K, Saito T, Umebayashi T, Jinno M, Takayama M, Honda Y
Organizer
The 10th EAOM (Biennial Conference of the European Association of Oral Medicine)
Place of Presentation
London
Related Report
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[Presentation] In vivo electroporation enhnaces the DNA vaccine potency against hamster oral papillomavirus-associated oral cancer.2008
Author(s)
Maeda H, Sugita Y, Kubo K, Sato E, Suzumura Y, Jinno M, Takayama K, Honda Y, Komori A
Organizer
14^<th> International Congress, International Association of Oral Pathologists
Place of Presentation
San Francisco, California, USA
Year and Date
2008-06-23
Related Report
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