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Mechanisms of taste cell differentiation : interaction between taste cells and taste nerves in reconstruction system

Research Project

Project/Area Number 20592177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionKagoshima University

Principal Investigator

HARADA Shuitsu (2009-2010)  Kagoshima University, 医歯学総合研究科, 教授 (60128452)

三浦 裕仁 (2008)  Kagoshima University, 大学院・医歯学総合研究科, 准教授 (80353936)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Ayumi  鹿児島大学, 医歯学総合研究科, 助教 (10398290)
MIURA Hirohito  鹿児島大学, 医歯学総合研究科, 准教授 (80353936)
原田 秀逸  鹿児島大学, 大学院・医歯学総合研究科, 教授 (60128452)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords口腔生理学 / 味覚 / 神経科学 / 細胞分化 / 味蕾 / 味神経
Research Abstract

The involvement of taste nerves in the regional differences in taste cell differentiation, and the regional differences in taste transduction machinery were analyzed between the soft palate and fungiform papillae. Our results suggested that taste nerves may not be involved in the regional differences in taste cell differentiation, and that the difference in bitter taste transduction may be caused by the differences in not only Gα proteins but also bitter taste receptors.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (19 results)

  • [Journal Article] Taste bud regeneration and the search for taste progenitor cells2010

    • Author(s)
      Miura H, Barlow L
    • Journal Title

      Arch Ital Biol Vol.148, No.2

      Pages: 107-118

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lrmp/Jaw1 is expressed in sweet, bitter and umami receptor-expressing cells.2010

    • Author(s)
      Shindo Y, Kim MR, Miura H, Yuuki T, Kanda T, Hino A, Kusakabe Y
    • Journal Title

      Chem.Senses Vol.35, No.2

      Pages: 171-177

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gustducinを介さない苦味情報伝達系のlicking解析による評価2010

    • Author(s)
      大木誠, 三浦裕仁, 友成博, 中山歩, Robert F. Margolskee, 二ノ宮裕三, 原田秀逸
    • Journal Title

      味と匂学会誌 Vol.17, No.3

      Pages: 223-224

    • NAID

      110008451319

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Taste bud regeneration and the search for taste progenitor cells.2010

    • Author(s)
      Miura H, Barlow L.
    • Journal Title

      Arch Ital Boiol

      Volume: 148(2) Pages: 107-118

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lrmp/Jawl is expressed in sweet, bitter and umami receptor-expressing cells.2010

    • Author(s)
      Shindo Y, Kim MR, Miura H, Yuuki T, Kanda T, Hino A, Kusakabe Y
    • Journal Title

      Chem Senses

      Volume: 35(2) Pages: 223-224

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gustducinを介さない苦味情報伝達系のlicking解析による評価2010

    • Author(s)
      大木誠, 三浦裕仁, 友成博, 中山歩, Robert F.Margolskee, 二ノ宮裕三, 原田秀逸
    • Journal Title

      味と匂学会誌

      Volume: 17(3) Pages: 223-224

    • NAID

      110008451319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 味蕾細胞特異的に発現する遺伝子の口腔内の部位による多様な発現様式2009

    • Author(s)
      日下部裕子, 進藤洋一郎, 三浦裕仁, カルニンチ ピエロ, 河合純, 林崎良英, 二ノ宮裕三, 日野明寛
    • Journal Title

      味と匂学会誌 Vol.16, No.3

      Pages: 269-270

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 軟口蓋味蕾の味覚受容体発現パターンとgustducin KO マウスの軟口蓋味蕾の味覚応答解析2009

    • Author(s)
      友成博, 三浦裕仁, 中山歩, 松村江梨子, 進藤洋一郎, 日下部裕子, Robert F Margolskee, 二ノ宮裕三, 原田秀逸
    • Journal Title

      日本味と匂学会誌 Vol.16, No.3

      Pages: 319-320

    • NAID

      110007568725

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] マウス味蕾における線維芽細胞増殖因子Fgf およびその受容体Fgfr のRT-PCR 解析2009

    • Author(s)
      松村江梨子, 三浦裕仁, 中山歩, 友成博,大木誠, 原田秀逸
    • Journal Title

      日本味と匂学会誌 Vol.16, No.3

      Pages: 291-292

    • NAID

      110007568694

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 軟口蓋味蕾の味覚受容体発現パターンと gustducin KOマウスの軟口蓋味蕾の味覚応答解析2009

    • Author(s)
      友成博, 三浦裕仁, 中山歩, 松村江梨子, 進藤洋一郎, 日下部裕子, Robert F Margolskee, 二ノ宮裕三, 原田秀逸
    • Journal Title

      日本味と匂学会誌 16(3)

      Pages: 319-320

    • NAID

      110007568725

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マウス味蕾における線維芽細胞増殖因子Fgfおよびその受容体FgfrのRT-PCR解析2009

    • Author(s)
      松村江梨子, 三浦裕仁, 中山歩, 友成博, 大木誠, 原田秀逸
    • Journal Title

      日本味と匂学会誌 16(3)

      Pages: 291-292

    • NAID

      110007568694

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 軟口蓋味蕾の味覚受容体発現パターンとgustducin ノックアウトマウスの軟口蓋味蕾の味覚応答解析2008

    • Author(s)
      友成博, 三浦裕仁, 中山歩, 松村江梨子, 進藤洋一郎, 日下部裕子, Robert F Margolskee, 二ノ宮裕三, 原田秀逸
    • Journal Title

      日本味と匂学会誌 Vol.15, No.3

      Pages: 419-422

    • NAID

      110007369657

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大錐体神経と鼓索神経とをつなぎ換えて再生させた味蕾の細胞分化2008

    • Author(s)
      中山歩, 友成博, 三浦裕仁, 松村江梨子, 原田秀逸
    • Journal Title

      日本味と匂学会誌 Vol.15, No.3

      Pages: 357-358

    • NAID

      110007369639

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gα14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue.2008

    • Author(s)
      Shindo Y, Miura H, Carninci P, Kawai J, Hayashizaki Y, Ninomiya Y, Hino A, Kanda T, Kusakabe Y
    • Journal Title

      Biochem.Biophys.Res.Commun Vol.509, No.2

      Pages: 211-224

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galphal4 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue.2008

    • Author(s)
      Shindo Y, Miura H, Carninci P, Kawai J, Hayashizaki Y, Ninomiya Y, Hino A, Kanda T, Kusakabe Y
    • Journal Title

      Biochem Biophys Res Commun. 376

      Pages: 504-508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大錘体神経と鼓索神経とをつなぎ換えて再生させた味蕾の細胞分化2008

    • Author(s)
      中山歩, 友成博, 三浦裕仁, 松村江梨子, 原田秀逸
    • Journal Title

      日本味と匂学会誌 15(3)

      Pages: 357-358

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 軟口蓋味蕾の味覚受容体発現パクーンとgustducin ノックアウトマクスの軟口蓋味蕾の味覚応答解析2008

    • Author(s)
      友成博, 三浦裕仁, 中山歩, 松村江梨子, 進藤洋一郎, 日下部裕子, Robert F Margolskee, 二ノ宮裕三, 原田秀逸
    • Journal Title

      日本味と匂学会誌 15(3)

      Pages: 419-422

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Appearance of Proxl cells during taste bud development and turnover2010

    • Author(s)
      三浦裕仁, 中山歩, 大木誠, 原田秀逸
    • Organizer
      The 8^<th> International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Preception
    • Place of Presentation
      福岡市
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 味蕾細胞の発生とターンオーバーにおけるProx1 細胞の出現(Appearance of Prox1 cells during taste bud development and turnover)2010

    • Author(s)
      三浦裕仁、中山歩、大木誠、原田秀逸
    • Organizer
      第8回国際シンポジウム「味覚・嗅覚の分子神経機構」(The8th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception)
    • Place of Presentation
      日本、福岡
    • Year and Date
      2010-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Gustducinを介さない苦味情報伝達系のlicking解析による評価2010

    • Author(s)
      大木誠, 三浦裕仁, 友成博, 中山歩, Robert F.Margolskee, 二ノ宮裕三, 原田秀逸
    • Organizer
      第44回 日本味と匂学会大会
    • Place of Presentation
      北九州市
    • Related Report
      2010 Annual Research Report
  • [Presentation] gustducin ノックアウトマウスの味覚応答と味覚受容関連分子の発現パターンの解析2009

    • Author(s)
      友成博, 三浦裕仁, 中山歩, 松村江梨子, 大木誠, 進藤洋一郎, 日下部裕子, Robert F Margolskee, 二ノ宮裕三, 原田秀逸
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      北海道 旭川
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスの味蕾における線維芽細胞増殖因子Fgfおよびその受容体Fgfrの発現2009

    • Author(s)
      松村江梨子, 三浦裕仁, 中山歩, 友成博, 大木誠, 原田秀逸
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      北海道 旭川
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス舌後方における甘味・うま味情報伝達分子候補としてのGα14(Gα14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue)2008

    • Author(s)
      進藤洋一郎、三浦裕仁、カルニンチピエロ、河合純、林崎良英、二ノ宮裕三、日野明寛、神田智正、日下部裕子
    • Organizer
      第6回国際シンポジウム「味覚・嗅覚の分子神経機構」(The 6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception)
    • Place of Presentation
      日本、福岡
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 味蕾II 型細胞におけるgustducin とIP3R3 の発現の部位差は神経に依存しない(Regional difference in gustducin and IP3R3 expression in Type II taste bud cells is nerve-independent)2008

    • Author(s)
      三浦裕仁、友成博、中山歩、松村江梨子、原田秀逸
    • Organizer
      第6回国際シンポジウム「味覚・嗅覚の分子神経機構」(The 6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception)
    • Place of Presentation
      日本、福岡
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 味蕾II型細胞におけるgustdueinとIP3R3の発現の部位差は神経に依存しない2008

    • Author(s)
      三浦裕仁, 友成博, 中山歩, 松村江梨子, 原田秀逸
    • Organizer
      第6回国際シンポジウム「味覚・嗅覚の分子神経機構」
    • Place of Presentation
      九州大学西新プラザ(福岡市)
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟口蓋味蕾の味覚受容体発現パターンとgustducin ノックアウトマウスの味覚神経応答2008

    • Author(s)
      友成博、中山歩、三浦裕仁、松村江梨子、進藤洋一郎、日下部裕子、二ノ宮裕三、Robert F Margolskee、原田秀逸
    • Organizer
      日本味と匂学会第42回大会
    • Place of Presentation
      日本、富山
    • Related Report
      2010 Final Research Report
  • [Presentation] 大錐体神経と鼓索神経とをつなぎ換えて再生させた味蕾の細胞分化2008

    • Author(s)
      中山歩、友成博、三浦裕仁、松村江梨子、進藤洋一郎、日下部裕子、原田秀逸
    • Organizer
      日本味と匂学会第42回大会
    • Place of Presentation
      日本、富山
    • Related Report
      2010 Final Research Report
  • [Presentation] Cell differentiation of the taste buds on the soft palate and fungiform papillae reconnected to different gustatory nerves2008

    • Author(s)
      原田秀逸, 友成博, 中山歩, 進藤洋一郎, 日下部裕子, 三浦裕仁
    • Organizer
      第15回嗅覚・味覚国際シンポジウム(The 15th International Symposium on Olfaction and Taste (ISOT))(共催第30回米国化学感覚学会)
    • Place of Presentation
      米国、カルフォルニア
    • Related Report
      2010 Final Research Report
  • [Presentation] The function of the gustducin in the soft palate taste buds differs from that in the tongue2008

    • Author(s)
      Nakayama A, Tomonari H, Miura H, Shindo Y, Kusakabe Y, Ninomiya Y, Margolskee R, Harada, S
    • Organizer
      第15回嗅覚・味覚国際シンポジウム(The 15th International Symposium on Olfaction and Taste (ISOT))(共催第30回米国化学感覚学会)
    • Place of Presentation
      米国、カルフォルニア
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of the basal cell markers of taste buds during mouse embryonic development.2008

    • Author(s)
      三浦裕仁, 中山歩, 進藤洋一郎, 日下部裕子, 友成博, 原田秀逸
    • Organizer
      第15回嗅覚・味覚国際シンポジウム(The 15th International Symposium on Olfaction and Taste (ISOT))(催第30回米国化学感覚学会)
    • Place of Presentation
      米国、カルフォルニア
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of Shh, Proxl and Mashl in the tastebud buring mouse embryonic development2008

    • Author(s)
      Miura Hirohito, Nakayama Ayumi, Shindo Yoichiro, Kusakabe Yuko, Tomonari Hiroshi, Harada Shuitsu
    • Organizer
      The International Symposium on Olfaction and Taste
    • Place of Presentation
      Hyatt Regency(米国・サンフランシスコ)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell differentiation of the taste buds on the soft palate and fungi form papillae reconnected to different gustatory nerves2008

    • Author(s)
      Harada Shuitsu, Tomonari Hiroshi, Nakayama Ayumi, Shindo Yoichiro, Kusakabe Yuko, Miura Hirohito
    • Organizer
      The International Symposium on Olfaction and Taste
    • Place of Presentation
      Hyatt Regency(米国・サンフランシスコ)
    • Related Report
      2008 Annual Research Report
  • [Presentation] The function of the gustducin in the soft palate taste buds differs from that in the tongue2008

    • Author(s)
      Nakayama Ayumi, Tomonari Hiroshi, Miura Hirohi to, Shindo Yoichiro, Kusakabe Yuko, Ninomiya Yuzo, Margolskee Robert, Harada Shuitsu
    • Organizer
      The International Symposium on Olfaction and Taste
    • Place of Presentation
      Hyatt Regency(米国・サンフランシスコ)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟口蓋味蕾の味覚受容体発現パターンとgustducinノックアウトマウスの味覚神経応答2008

    • Author(s)
      友成博, 三浦裕仁, 中山歩, 松村江梨子, 進藤洋一郎, 日下部裕子, Robert F Margolskee, ニノ宮裕三, 原田秀逸
    • Organizer
      日本味と匂学会
    • Place of Presentation
      富山市民プラザ(富山市)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大錐体神経と鼓索神経とをつなぎ換えて再生させた味蕾の細胞分化2008

    • Author(s)
      中山歩, 友成博, 三浦裕仁, 松村江梨子, 原田秀逸
    • Organizer
      日本味と匂学会
    • Place of Presentation
      富山市民プラザ(富山市)
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットの大錐体神経と鼓索神経つなぎ換えで再生した味蕾2008

    • Author(s)
      中山歩, 友成博, 三浦裕仁, 原田秀逸
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      TOC有明コンベンションホール(東京都)
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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