Development of novel drugs to control oral biofilms towards clinical application
| Project/Area Number |
20592181
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
KATO Hirohisa Iwate Medical University, 歯学部, 教授 (60152740)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Yasuo 愛知学院大学, 歯学部, 准教授 (10315096)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | バイオフィルム / 酵素 / う蝕 / 歯周病 / インドール / 歯周病細菌 / 多糖 / レンサ球菌 / D-galactose eiperase |
|---|
| Research Abstract |
The Shiitake extracts inhibited the biofilm formation of Streptococcus mutans in dose dependent manner. By contrast, the extracts did not affect the growth of the planktonic bacterial cells. It was suggested that the effective components are produced in time dependent manner. In addition, it was elucidated that the enzymatic activity of S. mutans glycosyltransferases was inhibited by the Shiitake extracts. These results revealed the possibility that the effective materials from Shiitake and related species might be clinically available as drugs to reduce dental caries.
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Report
(4 results)
Research Products
(21 results)
