| Project/Area Number |
20592187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SHIBUKAWA Yoshiyuki Tokyo Dental College, 歯学部, 講師 (30276969)
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| Co-Investigator(Kenkyū-buntansha) |
MURAMATSU Takashi 東京歯科大学, 歯学部, 講師 (00276982)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 歯学 / 口腔生理学 / カルシウムシグナル / 歯牙発生 / 再生医学 / Ca^<2+>シグナル / シグナル伝達 / 発現制御 / Caシグナル / 歯胚 / 歯牙 / 発生 / 細胞内カルシウム / カルシウムイオン / 象牙芽細胞 / イオン チャネル / トランスポーター |
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| Research Abstract |
To clarify the factor(s) in determination of bucco-lingual asymmetry against mesio-distal axis in morphological tooth development, we examined the spatial asymmetrical distribution pattern of intracellular Ca^<2+> concentration in the cells composed the tooth germ. Group of cells located in the mesial side of tooth germ had high intracellular Ca^<2+> concentration, compared with other areas in the tooth germ. Following stimulation of tooth germ with epithelial growth factor, transient increase in the intracellular Ca^<2+> concentration was observed in the group of cells located in the mesial side of tooth germ. The results indicate that, during tooth development, asymmetrical distribution high intracellular Ca^<2+> concentration in the group of cells via transient receptor potential (TRP) P2 (TRPP2) channels determines mesial side of tooth germ.
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