| Project/Area Number |
20592188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Research Collaborator |
BUCKMASTER Paul 米国スタンフォード大学, 医学部, 准教授
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経科学 / 生理学 / 解剖学 / 薬理学 / 歯学 / 島皮質 / 味覚 / 抑制性シナプス後電流 / 局所回路 / 可塑性 / パッチクランプ法 / 光学計測法 / GABA / 錐体細胞 / 抑制性ニューロン / 光学計測 / 興奮伝播 / pERK / てんかん / 神経回路 / ノルアドレナリン / グルタミン酸 / 放出確率 / 生後発達 |
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| Research Abstract |
The present study demonstrated the spatial distribution patterns of GABAergic neurons in rat insular cortex. In addition, the neural mechanisms of local circuits of the insular cortex, which consists of excitatory and inhibitory neurons, were explored, and the effects of agonists of adrenergic β-, muscarinic, and GABA_B receptors were examined by multiple whole-cell patch-clamp recording.
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