| Project/Area Number |
20592204
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
KIMURA Yasuo Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (30253686)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406)
HOTOKEZAKA Yuka 長崎大学, 大学病院, 講師 (10244089)
TASHIRO Shigeki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20300882)
TAKAGI Yukinori 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30295084)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | FEN1 / 自己免疫疾患 / MRI / 拡散強調撮像 / IQIマウス / ERストレス / XBP=1 |
|---|
| Research Abstract |
I performed various examination in FEN1 transgenic mouse, but was not able to confirm it whether autoimmune disease developed. I confirmed the lymphocyte permeation of the salivary gland (submandibular gland, sublingual gland) in the IQI mouse which was a mouse of the autoimmune disease instead. However, it was difficult to confirm a meaningful difference between a normal mouse by MR imaging (diffusion emphasis imaging) about the minute change of these salivary glands.
|
