Autoimmune Disease of FEN1 Transgenic Mouse

• Project/Area Number: 20592204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Nagasaki University
• Principal Investigator: KIMURA Yasuo Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (30253686)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406) ; HOTOKEZAKA Yuka 長崎大学, 大学病院, 講師 (10244089) ; TASHIRO Shigeki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20300882) ; TAKAGI Yukinori 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30295084)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: FEN1 / 自己免疫疾患 / MRI / 拡散強調撮像 / IQIマウス / ERストレス / XBP=1

Research Abstract

I performed various examination in FEN1 transgenic mouse, but was not able to confirm it whether autoimmune disease developed. I confirmed the lymphocyte permeation of the salivary gland (submandibular gland, sublingual gland) in the IQI mouse which was a mouse of the autoimmune disease instead. However, it was difficult to confirm a meaningful difference between a normal mouse by MR imaging (diffusion emphasis imaging) about the minute change of these salivary glands.

Research Products

• [Remarks] ホームページ等