• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Is transporters of scintigraphic agents useful as tumor makers

Research Project

Project/Area Number 20592207
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKagoshima University

Principal Investigator

KAWABATA Yoshihiro  Kagoshima University, 医学部・歯学部附属病院, 助教 (70274842)

Co-Investigator(Kenkyū-buntansha) SATO Tsuyoshi  鹿児島大学, 医歯学総合研究科, 准教授 (60098978)
MAJIMA Hideyuki  鹿児島大学, 医歯学総合研究科, 教授 (60165701)
SENBA Ichiro  鹿児島大学, 医歯学総合研究科, 教授 (60145505)
NAKAMURA Norifumi  鹿児島大学, 医歯学総合研究科, 教授 (60217875)
佐藤 強志  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (90136888)
濱平 須美子  鹿児島大学, 大学院・医歯学総合研究科, 助教 (10399917)
Co-Investigator(Renkei-kenkyūsha) KAMIMURA Ryozo  鹿児島大学, 医歯学総合研究科, 准教授
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords腫瘍マーカー / 放射性薬品 / 輸送蛋白 / 口腔扁平上皮癌 / 免疫組織染色 / 核医学 / 免疫染色 / 放射性薬品輸送蛋白 / 口腔悪性腫瘍 / L-アミノ酸輸送蛋白 / グルコース輸送蛋白 / PET
Research Abstract

Expression of transporters of scintigraphic agents on cell membrane was evaluated immunohistochemically using patients with squamous cell carcinoma in oral lesion and animal models with squamous cell carcinoma. Transport proteins of glucose transporter, P-glycoprotein, Na/K-ATPase and L-amino acid transporter found on cell membrane and showed a distinct correlation with tumor malignancy, tissue differentiation and accumulation of nuclear agents in tumor cells. These results indicated a possibility that transport proteins were useful as tumor marker for diagnosis of malignant tumors.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (12 results)

  • [Journal Article] Sugihara K. Making the best use of our previous results as a clue for interpreting kinetics of scintigraphic agents.2011

    • Author(s)
      Sato T, Morita Y, Kawabata Y, Majima H.
    • Journal Title

      JSDR (有受理、掲載予定)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Making the best use of our previous results as a clue for interpreting kinetics of scintigraphic agents2011

    • Author(s)
      Sato, T., Kawabata, Y., etc
    • Journal Title

      Japanese Dental Science Review (JDSR)

      Volume: (投稿中・受理)

    • NAID

      10029547912

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 上顎に発生した骨形成性粘表皮癌の画像所見2010

    • Author(s)
      川畑義裕、佐藤強志、馬嶋秀行
    • Organizer
      第15回臨床画像大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Scintigraphy for oral malignant lesions2010

    • Author(s)
      佐藤強志, 川畑義裕, 馬嶋秀行
    • Organizer
      88^<th> International Association of Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 全身疾患に伴う顎関節骨変化の画像所見の検討2010

    • Author(s)
      川畑義裕、佐藤強志、馬嶋秀行
    • Organizer
      第51回日本歯科放射線学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 全身疾患に伴う顎関節骨変化の画像所見の検討2010

    • Author(s)
      川畑、佐藤, その他
    • Organizer
      第51回日本歯科放射線学会総会
    • Place of Presentation
      横浜(鶴見大学)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Scintigraphy for oral malignant lesions2010

    • Author(s)
      Sato, T., Kawabata, Y., etc
    • Organizer
      88^<th> International Association of Dental Research (IADR)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上顎に発生した骨形成性粘表皮癌の画像所見2010

    • Author(s)
      川畑、佐藤, その他
    • Organizer
      第15回臨床画像大会
    • Place of Presentation
      鹿児島(鹿児島大学)
    • Related Report
      2010 Annual Research Report
  • [Presentation] SAPHO 関連性骨髄炎と細菌性骨髄炎における下顎骨骨変化の画像所見2009

    • Author(s)
      川畑義裕、佐藤強志、馬嶋秀行
    • Organizer
      第14回臨床画像大会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] SAPHO関連性骨髄炎と細菌性骨髄炎における下顎骨骨変化の画像所見2009

    • Author(s)
      川畑義裕, 佐藤強志
    • Organizer
      日本歯科放射線学会 第14回臨床画像大会
    • Place of Presentation
      北海道、札幌
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interpretation of SUV of FDG-PET in oral malignant tumors.2009

    • Author(s)
      佐藤強志, 川畑義裕,馬嶋秀行
    • Organizer
      17^<th> ICDMFR
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2009-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Interpretation of SUV of FDG-PET in oral malignant tumors2009

    • Author(s)
      佐藤強志, 川畑義裕, etc
    • Organizer
      17^<th>International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2009-07-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Subclassification of Warthin tumor by Tc-99m-Sialoscintigraphy.2008

    • Author(s)
      佐藤強志, 川畑義裕,馬嶋秀行
    • Organizer
      The 7^<th> ACOMFR
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Subclassification of Warthin's tumor by 99m-Tc Scintigraphy2008

    • Author(s)
      T. Sato, Y. Kawabata, et al.
    • Organizer
      7^<th> ACOMFR
    • Place of Presentation
      奈良県奈良市新公会堂
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi