The functional elucidation of salivary protein histatin toward the development of anti-inflammatory agent
| Project/Area Number |
20592210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
IMAMURA Yasuhiro Matsumoto Dental University, 歯学部, 講師 (00339136)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIGAKI Yoshihisa 松本歯科大学, 歯学部, 助教 (80367523)
ARA Toshiaki 松本歯科大学, 歯学部, 助教 (90387423)
FUJINAMI Yoshiaki 松本歯科大学, 歯学部付属病院, 助手 (80392801)
WANG PaoーLi 大阪歯科大学, 歯学部, 教授 (20213613)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 唾液蛋白質 / ヒスタチン / 炎症 / 細胞周期 / 熱ショック蛋白質 / 細胞増殖 / Toll様受容体 |
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| Research Abstract |
Salivary protein histatin has antimicrobial activity toward pathogenic bacteria of periodontitis. However, the effect of histatin on living body (host) is scarcely clarified. In this study, histatin showed the enhancement of human gingival fibroblast (which constitute the major cellular population of gingival tissue) proliferation. It became apparent that histatin is an anti-inflammatory factor. These observations suggest that wound healing induced by inflammatory, etc., in the oral cavity is earlier than that in the other tissues and organs. Moreover, it seems more likely that the salivary protein is developed as an anti-inflammatory agent.
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Report
(4 results)
Research Products
(11 results)
