| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
T cells play a key role in periodontitis through their ability to migrate into tissues. CXCL12 is one of the chemokines that promote leukocytes invasion and migration into tissues, while the exact molecular mechanisms are not clear at present. In this study, we showed that CXCL12 significantly enhances T cells invasion into type I collagen by the catalytic activity of MMP-1. The production of pro-MMP-1 with CXCL12 required activation of JAK. Confocal immunofluorescence study suggests that MMP-1 is not localized on CXCL-12-stimulated JAK knock down T cell surface.
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