Development of the treatment for acute coronary syndrome by dental bacteria elimination

• Project/Area Number: 20592214
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kurume University
• Principal Investigator: SASAKI Ken-Ichiro (2010) Kurume University, 医学部, 助教 (70320190); 香月 与志夫 (2008-2009) Kurume University, 医学部, 助教 (10389249)
• Co-Investigator(Kenkyū-buntansha): YOSHIO Katsuki 久留米大学, 医学部, 助教 (10389249) ; TOYAMA Yasuyuki 久留米大学, 医学部, 助教 (40412506) ; 佐々木 健一郎 久留米大学, 医学部, 助教 (70320190)
• Co-Investigator(Renkei-kenkyūsha): TSUKUBA Tomoko 九州大学, 歯学研究科学研究院, 助教 (70336080)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 虚血性心臓病 / 急性冠症候群 / 動脈硬化 / 血管内プラーク / 歯周病菌 / 感染 / 炎症 / 歯周病治療 / 免疫

Research Abstract

In 174 patients with acute coronary syndrome (ACS), the DNA of P. gingivalis, which is a representative responsible bacterium for periodontal disease (PD), was detected in 58% of the sample including the coronary artery blood and the atherosclerotic plaque. Moreover, the activity of Gingipain, which is a protease from the bacterium, increased in the plaque. Although we speculated that the treatment of PD can prevent the protease-induced plaque rupture for ACS and thereby reduce the major adverse cardiac event, the detection of the bacterium in the sample did not influence to the event rate at 6 months after the onset of ACS in the prognosis research for average 14.8 months.

Research Products

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