The functional roles of IL-10 in periapical inflammation

• Project/Area Number: 20592222
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SUZUKI Noriyuki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (20372451)
• Research Collaborator: STASHENKO Philip The Forsyth Institute ; SASAKI Hajime The Forsyth Institute
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 根尖性歯周炎 / IL-10 / Th1サイトカイン

Research Abstract

The periapical lesion is a granuloma containing a mixed inflammatory infiltrate induced by local immune reaction, however, its pathogenesis and the mechanism of expansion are still unclear. In this study, we examined the roles of IL-10 and Th1 cytokines in periapical inflammation using knockout (KO) mice. We conclude that IL-12-dependent T cell-mediated responses seem to induce hyper periapical inflammation in IL-10 KO mice.

Research Products

• [Journal Article] 18 -Glycyrrhetinic acid inhibits periodontitis via glucocorticoid -independent nuclear factor- B inactivation in interleukin-10-deficient mice (2010)
  • Author(s): Sasaki H, Suzuki N, Alshwaimi E, Xu Y, Battaglino R, Morse L, Stashenko P
  • Journal Title: J Periodont Res Vol.45 Pages: 757-763
  • Peer Reviewed
• [Journal Article] 18b-Glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-kB inactivation in interleukin-10-deficientmice (2010)
  • Author(s): Sasaki H, Suzuki N, Alshwaimi E, Xu Y, Battaglino R, Morse L, Stashenko P
  • Journal Title: Journal of Periodontal Research Volume: 45 Pages: 757-763
  • Peer Reviewed
• [Journal Article] Protective Role of Osteopontin in Endodontic Infection (2010)
  • Author(s): Rittling S, Zetterberg C, Yagiz K, Skinner S, Suzuki N, Fujimura A, Sasaki H
  • Journal Title: Immunology 129 Pages: 105-114
  • Peer Reviewed
• [Journal Article] Protective role of osteopontin in endodontic infection (2009)
  • Author(s): Rittling S, Zetterberg C, Yagiz K, Skinner S, Suzuki N, Fujimura A, Sasaki H
  • Journal Title: Immunology Vol.129 Pages: 105-114
  • Peer Reviewed
• [Journal Article] T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10 deficient mice (2008)
  • Author(s): Sasaki H, Suzuki N, Kent R, Kawashima N, Takeda J, Stashenko P
  • Journal Title: J Immunol Vol.180 Pages: 6193-6198
  • Peer Reviewed
• [Journal Article] T cell response mediated by myeloid cell-derived IL-12 isresponsible for Porphyromonas gingiva/is-inducedperiodontitis in IL-10-deficient mice (2008)
  • Author(s): Sasaki H, Suzuki N, Kent R, Kawashima N, Takeda J, Stashenko P
  • Journal Title: Journal of Immunology 180 Pages: 6193-6198
  • Peer Reviewed
• [Presentation] Promotive effects of Sp7 on Dspp expression (2010)
  • Author(s): Kawashima N, Xu J, Iwata T, Takahashi S, Koizumi Y, Takimoto K, Zhou M, Ohi C, Suzuki N, Sugiyama T, Suda H
  • Organizer: IADR 88th General Session
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-17
• [Presentation] Effective suppression of periapical lesion expansion by Cathepsin K inhibitor (2010)
  • Author(s): 鈴木規元, 川島伸之, 許, 須田英明
  • Organizer: IADR 88th General Session
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 2010-07-16
• [Presentation] Effective suppression of periapical lesion expansion by Cathepsin Kinhibitor (2010)
  • Author(s): Suzuki N, Kawashima N, Xu J, Suda H
  • Organizer: IADR 88th General Session
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] ラット実験的根尖性歯周炎の進展におけるカテプシンK阻害剤の抑制効果 (2009)
  • Author(s): 鈴木規元、川島伸之、許、須田英明
  • Organizer: 第131回日本歯科保存学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-30
• [Presentation] Expression of Th17 related cytokines in experimentally-induced rat periapical lesions (2009)
  • Author(s): Wei S, Kawashima N, Suzuki N, Xu J, Takahashi S, Zhou M, Koizumi Y, Suda H
  • Organizer: The 15th Asian Pacific Endodontic Confederation
  • Place of Presentation: 東京
  • Year and Date: 2009-04-25
• [Presentation] VIP receptor expression in tooth development (2009)
  • Author(s): Xu J, Kawashima N, Suzuki N, Okuhara S, Wei S, Takahashi S, Zhou M, Koizumi Y, Suda H
  • Organizer: The 15th Asian Pacific Endodontic Confederation
  • Place of Presentation: 東京
  • Year and Date: 2009-04-25
• [Presentation] IL-10ノックアウトマウスに誘発した根尖性歯周炎におけるIL-12の役割 (2008)
  • Author(s): 鈴木規元、川島伸之、須田英明
  • Organizer: 第128回日本歯科保存学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-06-06
• [Presentation] TL-10ノックアウトマウスに誘発した根尖性歯周炎におけるIL-12の役割 (2008)
  • Author(s): 鈴木規元, 川島伸之, 須田英明
  • Organizer: 第128回日本歯科保存学会春季学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2008-06-06