| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The periapical lesion is a granuloma containing a mixed inflammatory infiltrate induced by local immune reaction, however, its pathogenesis and the mechanism of expansion are still unclear. In this study, we examined the roles of IL-10 and Th1 cytokines in periapical inflammation using knockout (KO) mice. We conclude that IL-12-dependent T cell-mediated responses seem to induce hyper periapical inflammation in IL-10 KO mice.
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