Fluorine quantitative measurement in macro area of the tooth using nuclear reaction

• Project/Area Number: 20592224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: YAMAMOTO Hiroko Osaka University, 大学院・歯学研究科, 招へい教員 (60448107)
• Co-Investigator(Kenkyū-buntansha): IWMAI Yukiteru 大阪大学, 大学院・歯学研究科, 助教 (90303982)
• Co-Investigator(Renkei-kenkyūsha): NOUMACHI Masaharu 大阪大学, 大学院・理学研究科, 教授 (90208299) ; YASUDA Keisuke 若狭湾エネルギー研究センター, 主任研究員 (00359241)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: フッ素 / PIGE / 定量測定法 / 歯質 / 虫歯 / フッ素定量測定 / う蝕歯質 / 再石灰化 / フッ素徐放性歯科材料 / う蝕 / 核反応 / 抗う蝕作用 / フッ素含有歯科材料

Research Abstract

We have developed a new method of quantitative measurement of fluorine in micro area of the tooth by using the nuclear reaction, for the clarification of a quantitative relation between fluorine and carious prevention. Next, we have developed a new method of quantitative measurement of fluorine in macro area of the tooth. By using this method (In-air micro-PIGE and micro-PIXE measurement system), the fluorine distribution all around the cavity was able to be measured for the first time though this area had not been able to be measured by earlier methods. And then the fluorine distribution in the tooth and in the thin layer of material was able to be measured quantitatively at the same time. In addition, it has been shown that the measurement of the fluorine distribution in the carious teeth was also possible. This system may provide future methodologies to clarify the effects of F distribution in the caries process.

Research Products

• [Journal Article] Relationship between laser fluorescence and bacterial invasion in arrested dentinal carious lesion (2011)
  • Author(s): Y.Iwami, et al
  • Journal Title: Lasers in Medical Science Volume: (In press)
  • Peer Reviewed
• [Journal Article] Measurement of Strontium Distribution in Carious Enamel and Dentin around a Fluoride-containing Material (2010)
  • Author(s): Komatsu H, Matsuda Y, Kijimura T, Okuyama K, Yamamoto H, Iwami Y, Ebisu, S, Nomachi M, Yasuda K, Satoh T, Kohka M
  • Journal Title: JAEA Takasaki Annual Report 2009, JAEA-Review 2010-065 Pages: 113-113
  • Peer Reviewed
• [Journal Article] う蝕病巣に対する客観的診断法の確立と病巣活動性の評価 (2010)
  • Author(s): 岩見行晃
  • Journal Title: 日本保存学会誌 Volume: 53 Pages: 486-488
  • NAID: 110008006917
  • Peer Reviewed
• [Journal Article] Measurement of Strontium Distribution in Carious Enamel and Dentin around a Fluoride-containing Material (2010)
  • Author(s): H Komatsu, et al
  • Journal Title: JAEA Takasaki Annual Report 2009 JAEA-Review Volume: 2010-065 Pages: 113-113
  • Peer Reviewed
• [Journal Article] Fluorine uptake into the human enamel around fluoride-containing dental materiald during cariogenic pH cycling (2009)
  • Author(s): Komatsu H, Yamamoto H, Nomachi M, Yasuda K, Mastuda Y, Kinugawa M, Kijimura T, Sano T, Satou T, Oikawa M, Kamiya T
  • Journal Title: Nucl Instr and Meth. B267 Pages: 2136-2139
  • Peer Reviewed
• [Journal Article] Measurement of fluorine distribution in carious enamel around fluoride-containing materials using PIGE/PIXE system (2009)
  • Author(s): Komatsu H., Matsuda Y., Kijimura T., Okuyama K., Yamamoto H., Iwami Y., Ebisu, S., Nomachi M., Yasuda K., Satoh T., Oikawa S.
  • Journal Title: JAEA Takasaki Annual Report 2008, JAEA-Review 2009-041 Pages: 113-113
  • Peer Reviewed
• [Journal Article] Development of a System for Measuring Fluoride Distribution in Teeth Using a Nuclear Reaction (2009)
  • Author(s): Yamamoto H, Iwami Y, Ebisu S, Nomachi M, Yasuda K, Sakai T, Kamiya T
  • Journal Title: IJPIXE 19 Pages: 91-102
  • Peer Reviewed
• [Journal Article] Fluorine uptake into the human enamel around fluoride-containing dental material during cariogenic pH cycling (2009)
  • Author(s): H.Komatsu, et al.
  • Journal Title: Nuclear Instruments and Methods in Physics Research, section B 267 Pages: 2136-2139
  • Peer Reviewed
• [Journal Article] Development of a System for Measuring Fluoride Distribution in Teeth Using a Nuclear Reaction (2009)
  • Author(s): H.Yamamoto, et al.
  • Journal Title: International Journal of PIXE 19 Pages: 91-102
  • Peer Reviewed
• [Journal Article] 新規う蝕検知液 Caries Check によるう蝕除去の客観性 (2009)
  • Author(s): 岩見行晃, ら
  • Journal Title: 日本歯科保存学会誌 52(5) Pages: 384-391
  • NAID: 110007539259
  • Peer Reviewed
• [Journal Article] Fluorine uptake into human enamel around fluoride-containing dental materials during cariogenic PH cycling (2009)
  • Author(s): H. Komatsu
  • Journal Title: Nuclear Instruments &Methords in Physics Research, Section B (In press)
  • Peer Reviewed
• [Journal Article] Development of a System for Measuring Fluoride Di stribution in Teeth Using a Nuclear Reaction (2009)
  • Author(s): H. Yaraamoto
  • Journal Title: INTERNATIONAL JOURNAL OF PIXE (In press)
  • Peer Reviewed
• [Journal Article] Effect of different immersion solutions on flurine uptake into enamel around fluoride-containing materials during pH-cycling (2008)
  • Author(s): Komatsu H., Matsuda Y., Kijimura T., Kinugawa M., Yamamoto H., Iwami Y., Ebisu, S., Nomachi M., Yasuda K., Satoh T., Oikawa S
  • Journal Title: JAEA Takasaki Annual Report 2007, JAEA-Review 2008-055 Pages: 116-116
  • Peer Reviewed
• [Journal Article] Effect of different immersion solutions on fluorine uptake into enamel around fluoride-containing materials during pH-cycling (2008)
  • Author(s): H. Komatsu
  • Journal Title: JAEA Takasaki Annual Report 2007 JAEA-Review 2008-055
  • Peer Reviewed
• [Presentation] フッ素徐放性材料充填長期経過後の歯質内のフッ素分布 (2010)
  • Author(s): 山本洋子、岩見行晃、恵比須繁之、小松久憲、安田啓介
  • Organizer: 第27回PIXEシンポジウム
  • Place of Presentation: 京都大学
  • Year and Date: 2010-11-17
• [Presentation] フッ素徐放性材料充填長期経過後の歯質内のフッ素分布 (2010)
  • Author(s): 山本洋子
  • Organizer: 第27回PIXEシンポジウム
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2010-11-17
• [Presentation] 核反応法による歯質中のフッ素分布測定(IX) (2010)
  • Author(s): 小松久憲、松田康裕、奥山克史、木地村太基、山本洋子, 能町正治, 菅谷頼仁, 安田啓介, 佐藤隆博, 江夏昌志
  • Organizer: 第5回高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎シティギャラリー
  • Year and Date: 2010-10-08
• [Presentation] 核反応法による歯質中のフッ素分布測定(IX) (2010)
  • Author(s): 小松久憲, ら
  • Organizer: 第5回高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎シティーギャラリー(群馬)
  • Year and Date: 2010-10-08
• [Presentation] Time Dependence of Fluorine Uptake into the Human Tooth from the Thin Layer of F-releasing Material (2010)
  • Author(s): Yamamoto H, Komatsu H, Nomachi M, Sugaya Y, Iwami Y, Ebisu S, Yasuda K
  • Organizer: 12th ICNMTA
  • Place of Presentation: Leipzig (Germany)
  • Year and Date: 2010-07-27
• [Presentation] Present Status of the In-air Microbeam System at the Wakasa Wan Energy Researchi Center (2010)
  • Author(s): Yasuda K, Nomachi M, Sugaya Y, Yamamoto H, Komatsu H
  • Organizer: 12th ICNMTA
  • Place of Presentation: Leipzig (Germany)
  • Year and Date: 2010-07-27
• [Presentation] Fluorine Analysis of Human Enamel around Fluoride-containing Materials Different pH-cycling by μ -PIGE/PIXE System (2010)
  • Author(s): Komatsu H, Yamamoto H, Matsuda Y, Kijimura T, Kinugasa M, Okuyama K, Nomachi M, Yasuda K, Satoh T, Oikawa M
  • Organizer: 12th ICNMTA
  • Place of Presentation: Leipzig (Germany)
  • Year and Date: 2010-07-27
• [Presentation] Fluorine Analysis of Human Dentine around Resin Composite after Fluoride Application by μ -PIGE/PIXE System (2010)
  • Author(s): Okuyama K, Komatsu H, Yamamoto H, Pereira PN, Bedran-Russo AK, Nomachi M, Satoh T, Sano H
  • Organizer: 12th ICNMTA
  • Place of Presentation: Leipzig ( Germany)
  • Year and Date: 2010-07-27
• [Presentation] Time Dependence of Fluorine Uptake into the Human Tooth from the Thin Layer of F-releasing Material (2010)
  • Author(s): H.Yamamoto, et al
  • Organizer: 12th International Conference on Nuclear Microprobe Technology and Applications
  • Place of Presentation: Leipzig (Germany)
  • Year and Date: 2010-07-27
• [Presentation] Present Status of the In-air Microbeam System at the Wakasa Wan Energy Research Center (2010)
  • Author(s): K Yasuda, et al
  • Organizer: 12th International Conference on Nuclear Microprobe Technology and Applications
  • Place of Presentation: Leipzig (Germany)
  • Year and Date: 2010-07-27
• [Presentation] Fluoride Mapping of Human Tooth around Fluoride-releasing Materials using micro-PIGE (2010)
  • Author(s): Ymamoto H, Iwami Y, Ebisu S, Nomachi M, Sugaya Y, Komatsu H, Yasuda K
  • Organizer: 88h IADR 総会
  • Place of Presentation: Barcelona(CCIB) (Spain)
  • Year and Date: 2010-07-16
• [Presentation] Fluoride Mapping of Human Tooth around Fluoride-releasing Materials using micro-PIGE (2010)
  • Author(s): H.Yamamoto, et al
  • Organizer: 88^<th> General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona(CCIB) (Spain)
  • Year and Date: 2010-07-16
• [Presentation] フッ素含有材料からの歯質への長期フッ素取り込み量 (2010)
  • Author(s): 小松久憲、船戸良基、小島健太郎、木地村大基、奥山克史、佐野英彦、山本洋子、安田啓介
  • Organizer: 第132日本歯科保存学会春季学術大会
  • Place of Presentation: 熊本市民会館
  • Year and Date: 2010-06-04
• [Presentation] 核反応法による歯質中のフッ素分布測定(VIII) (2009)
  • Author(s): 小松久憲、松田康裕、奥山克史、木地村太基、山本洋子, 能町正治, 菅谷頼仁, 安田啓介, 佐藤隆博, 江夏昌志
  • Organizer: 第4回高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎シティギャラリー
  • Year and Date: 2009-10-10
• [Presentation] 核反応法による歯質中のフッ素分布測定 (VIII) (2009)
  • Author(s): 小松久憲, ら
  • Organizer: 第4回 高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎
  • Year and Date: 2009-10-10
• [Presentation] 核反応によるう蝕歯中のフッ素濃度分布の測定 (2009)
  • Author(s): 小松久憲、山本洋子、奥山克史、小島健太郎、木地村大基、佐野英彦
  • Organizer: 第130回日本歯科保存学会春季学術大会
  • Place of Presentation: 札幌コンベンションセンターSORA
  • Year and Date: 2009-06-11
• [Presentation] 核反応によるう蝕歯中のフッ素濃度分布の測定 (2009)
  • Author(s): 小松久憲, ら
  • Organizer: 第130回日本歯科保存学会春季学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-11
• [Presentation] 核反応法による歯質中のフッ素分布測定(VII) (2008)
  • Author(s): 小松久憲、松田康裕、木地村太基、山本洋子, 能町正治, 菅谷頼仁, 安田啓介, 佐藤隆博, 及川将一
  • Organizer: 第3回高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎シティギャラリー
  • Year and Date: 2008-10-10
• [Presentation] 核反応による歯質中のフッ素分布測定(VII) (2008)
  • Author(s): 小松久憲, 他
  • Organizer: 第3回高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎、群馬
  • Year and Date: 2008-10-10
• [Presentation] Fluorine Analysis of the Tooth around Fluoride-containing Filling Materials by the In-air micro-PIXE/PIGE System of TIARA (2008)
  • Author(s): H. KoDiatsu
  • Organizer: The 21st Century. COE Program The Fourth International Symposium on Biomedical Research Using Accelerator Technology
  • Place of Presentation: Maebashi, Japan
  • Year and Date: 2008-09-16
• [Presentation] Fluorine uptake into human enamel from fluoride-containing dental materials during cariogenic pH cycling (2008)
  • Author(s): Komatsu H, Yamamoto H, Nomachi M, Yasuda K, Matsuda Y, Kinugawa M, Kajimura T, Sano H, Satou T, Oikawa S, Kamiya T
  • Organizer: 11th ICNMTA
  • Place of Presentation: Debrecen (Hungary)
  • Year and Date: 2008-07-21
• [Presentation] Fluorine uptake into human enamel around fluoride-containing dental materials during cariogenic pH cycling (2008)
  • Author(s): H. Komatsu
  • Organizer: llth International Conference on Nuclear Microprobe Technology and Applications & 3rd International Workshop on Proton Beam Writing
  • Place of Presentation: Debrecen, Hungary
  • Year and Date: 2008-07-21