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Regeneration of dentin and alveolar bone using growth factors and ultrasound

Research Project

Project/Area Number 20592225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionOkayama University

Principal Investigator

YAMAJI Kouzou  Okayama University, 岡山大学病院, 講師 (30374531)

Co-Investigator(Kenkyū-buntansha) YOSHIYAMA Masahiro  岡山大学, 大学院・医歯薬学総合研究科, 教授 (10201071)
NISHITANI Yoshihiro  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60325123)
ODAJIMA Tomoomi  北海道大学, 大学院・歯学研究科, 助教 (80344521)
KAWANAMI Masamitsu  北海道大学, 大学院・歯学研究科, 教授 (10133761)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords増殖因子 / 超音波療法 / 象牙質形成 / 骨形成 / 象牙質再生 / 骨再生
Research Abstract

The purpose of this study was to evaluate the effect of dentin and bone regeneration using growth factor and ultrasound. As a result, the dentin formation was promoted by using the growth factor in the case of direct pulp capping. Newly formed bone was observed at subperiosteal sites using growth factor. Furthermore, the maturation of newly formed bone was enhanced by using ultrasound. These results suggest that growth factor and ultrasound have the ability to enhance hard tissue formation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (11 results)

  • [Journal Article] Effects of ultrasound on bone formation induced by BMP-22010

    • Author(s)
      Yamaji K, Nishimura M, Nishitani Y, Izawa S, Hoshika T, Shiode S, Yoshiyama M
    • Journal Title

      Journal of Oral Tissue Engineering 8(1)

      Pages: 47-51

    • NAID

      130004941164

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ultrasound on bone formation induced by BMP-22010

    • Author(s)
      Yamaji K, Nishimura M, Nishitani Y, Izawa S, Hoshika T, Shiode S, Yoshiyama M
    • Journal Title

      Journal of Oral Tissue Engineering

      Volume: 8 Pages: 47-51

    • NAID

      130004941164

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト骨髄間葉系幹細胞を用いた象牙芽細胞分化と象牙質再生2009

    • Author(s)
      伊澤俊次, 山路公造, 星加知宏, 中田貴, 神農泰生, 西谷佳浩, 吉山昌宏
    • Journal Title

      再生歯誌 7(1)

      Pages: 47-55

    • NAID

      130004941457

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲン固定化エチレンビニルアルコール共重合体(EVA+C)添加試作石灰化誘導促進性接着材の接着強さと生体親和性2009

    • Author(s)
      神農泰生, 岸本麻実, 穴吹優佳, 山路公造, 西谷佳浩, 田中亨, 佐野英彦, 吉山昌宏
    • Journal Title

      再生歯誌 7(1)

      Pages: 56-63

    • NAID

      130004941458

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト骨髄間葉系幹細胞を用いた象牙芽細胞分化と象牙質再生2009

    • Author(s)
      伊澤俊次, 山路公造, 星加知宏, 中田貴, 神農泰生, 西谷佳浩, 吉山昌宏
    • Journal Title

      日本再生歯科医学会誌 7

      Pages: 47-55

    • NAID

      130004941457

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲン固定化エチレン-ビニルアルコール共重合体(EVA+C)添加試作石灰化誘導促進性接着材の接着強さと生体親和性2009

    • Author(s)
      神農泰生, 岸本麻実, 穴吹優佳, 山路公造, 西谷佳浩, 田中亨, 佐野秀彦, 吉山昌宏
    • Journal Title

      日本再生歯科医学会誌 7

      Pages: 56-63

    • NAID

      130004941458

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dentin regeneration by direct pulp capping using rhBMP-2.2008

    • Author(s)
      Yamaji K, Horikawa G, Nishitani Y, Izawa S, Yoshiyama M
    • Journal Title

      Journal of Oral Tissue Engineering 5(3)

      Pages: 145-149

    • NAID

      130004456598

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of BMP-2 injected into the palatal sites on bone formation.2008

    • Author(s)
      Yamaji K, Takahashi K, Nishitani Y, Izawa S, Horikawa G, Nishimura M, Hoshika T, Yoshiyama M
    • Journal Title

      Journal of Oral Tissue Engineering 6(1)

      Pages: 62-66

    • NAID

      110007004840

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of BMP-2 injected into the palatal sites on bone formation.2008

    • Author(s)
      Yamaji Kozo
    • Journal Title

      Journal of Oral Tissue Engineering 6

      Pages: 62-66

    • NAID

      110007004840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 超音波がBMP骨膜注入後の骨形成に及ぼす影響2010

    • Author(s)
      山路公造、塩出信太郎、西谷佳浩、伊澤俊次、大原直子、田中久美子、西村麻衣子、吉山昌宏
    • Organizer
      第8回日本再生歯科医学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of ultrasound on bone formation induced by BMP-22010

    • Author(s)
      山路公造, 西村麻衣子, 西谷佳浩, 伊澤俊次, 星加知宏, 吉山昌宏
    • Organizer
      88^<th> International Association for Dental Research
    • Place of Presentation
      Barcerona, Spain, Poster
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of ultrasound on bone formation induced by BMP-22010

    • Author(s)
      Yamaji K, Nishimura M, Nishitani Y, Izawa S, Hoshika T, Yoshiyama M
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] BMPによる骨形成に対するCO2レーザーの影響2009

    • Author(s)
      塩出信太郎, 山路公造, 西谷佳浩, 堀川元, 伊澤俊次, 吉山昌宏
    • Organizer
      第7回日本再生歯科医学会学術大会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト骨髄間葉系幹細胞を用いた象牙質再生に関する研究2009

    • Author(s)
      伊澤俊次, 山路公造, 星加知宏, 中田貴, 神農泰生, 西谷佳浩, 吉山昌宏
    • Organizer
      第7回日本再生歯科医学会学術大会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] BMPによる骨形成に対するCO_2レーザーの影響2009

    • Author(s)
      塩出信太郎, 山路公造, 西谷佳浩, 堀川元, 伊澤俊次, 吉山昌宏
    • Organizer
      日本再生歯科医学会誌,7(1):89,2009.第7回日本再生歯科医学会
    • Place of Presentation
      北九州,ポスター
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト骨髄間葉系幹細胞を用いた象牙質再生に関する研究-リアルタイムRT-PCR法による遺伝子発現解析-2009

    • Author(s)
      伊澤俊次, 山路公造, 星加知宏, 中田貴, 神農泰生, 西谷佳浩, 吉山昌宏
    • Organizer
      第7回日本再生歯科医学会学術大会・総会
    • Place of Presentation
      北九州,ポスター
    • Related Report
      2010 Final Research Report
  • [Presentation] 超音波治療とBMP-2を用いた骨再生療法2008

    • Author(s)
      西村麻衣子, 山路公造, 堀川元, 西谷佳浩, 吉山昌宏
    • Organizer
      第6回日本再生歯科医学会学術大会・総会,プログラム・抄録集(abst P12)
    • Place of Presentation
      東京,ポスター
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 超音波療法とBMP-2を用いた骨再生療法2008

    • Author(s)
      山路公造
    • Organizer
      第6回日本再生歯科医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dentin-regeneration by the differentiated bone marrow mesenchymal stem cells2008

    • Author(s)
      Izawa S, Yamaji K, Shinno Y, Nishitani Y, Yoshiyama M
    • Organizer
      86^<th> International Association for Dental Research (abst 3367)
    • Place of Presentation
      Toronto, Canada, Poster
    • Year and Date
      2008-07-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of BMP-2 on bone formation at palatal subperiosteal sites2008

    • Author(s)
      山路公造, 西谷佳浩, 伊澤俊次, 吉山昌宏
    • Organizer
      86^<th> International Association for Dental Research (abst 2567)
    • Place of Presentation
      Toronto, Canada, Poster
    • Year and Date
      2008-07-04
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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