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Healing mechanism of rat experimental periapical lesions targeting laminin γ2 expression

Research Project

Project/Area Number 20592226
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionOkayama University

Principal Investigator

HATANAKA Kazu  Okayama University, 大学院・医歯薬学総合研究科, 助教 (50362992)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Tadashi  岡山大学, 岡山大学病院, 講師 (50432662)
TAKASHIBA Shougo  岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
SHIMOE Masayuki  岡山大学, 岡山大学病院, 医員 (60580264)
YAMAGUCHI Tomoko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (90580267)
NARUISHI Koji  岡山大学, 岡山大学病院, 講師 (00346446)
KAKO Aya  岡山大学, 岡山大学病院, 医員 (60448230)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords根尖性歯周炎 / 骨芽細胞 / IL-1 / ラミニン / 病巣治癒 / インターロイキン1α / 根尖病巣 / 冶癒 / MAPK / インターロイキン1a / 細胞増殖活性 / 細胞接着活性
Research Abstract

We have previously reported that cellular matrix laminin and inflammatory cytokine IL-1αgenes increased during periapical healing phase in a rat periapical periodontitis. In this study, we investigated the effect of these molecules to osteoblast that play a central role in bone formation. Our findings the enhancement of integrin α3 expression by IL-1α and the attachment of osteoblasts to laminin after stimulation with IL-1α suggest an important mechanism for adherence of osteoblasts in periapical healing.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] インターロイキン-1αによるマウス骨芽細胞様細胞MC3T3-E1の接着性の変化に関する研究2010

    • Author(s)
      冨山高史
    • Journal Title

      岡山歯学会雑誌 29巻

      Pages: 1-13

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] インターロイキン-1αによるマウス骨芽細胞様細胞MC3T3-E1の接着性の変化に関する研究2010

    • Author(s)
      冨山高史
    • Journal Title

      岡山歯学会雑誌

      Volume: 29 Pages: 1-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インターロイキン-1aによるマウス骨芽細胞様細胞MC3T3-E1の接着性の変化に関する研究2010

    • Author(s)
      冨山高史
    • Journal Title

      岡山歯学会雑誌 29(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] IL-1rαによるマウス骨芽細胞様細胞MC3T3-E1におけるIL-1誘導性OPGおよびIL-6の産生制御2010

    • Author(s)
      久保克行, ら
    • Organizer
      日本歯周病学会 春季学術大会(第53回)
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] IL-1rαによるマウス骨芽細胞様細胞MC3T3-E1におけるIL-1誘導性OPGおよびIL-6の産生制御2010

    • Author(s)
      久保克行
    • Organizer
      日本歯周病学会 2010春季学術大会(第53回)
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Perspective Basic and Clinical Research for Periodontal Diseases2009

    • Author(s)
      Koji Naruishi
    • Organizer
      Association for Dental Sciences of the Republic of China
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2009-11-29
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] <3【○R!】1 integrin- mediated MC3T3-E1 osteoblasts adherence induced by inteleukin-1<2008

    • Author(s)
      冨山高史, et al.
    • Organizer
      56^<th> Anuual Meeting, Japanese Association for Dental Research
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-11-30
    • Related Report
      2010 Final Research Report
  • [Presentation] α3β1 integrin-mediated MC3T3-E1 osteoblasts adherence induced by in terleukin-1α2008

    • Author(s)
      Takashi Tomiyama, Koji Naruishi, Kazuhiro Omori, Hiroshi Maeda, Shogo Takashiba
    • Organizer
      56^<th> Annual Meeting, 2008, Japanese Associationfor Dental Research
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-1αおよびIL-1βによるマウス骨芽細胞様細胞MC3T3-E1の動態におけるMAPK系の関与2008

    • Author(s)
      冨山高史, ら
    • Organizer
      日本歯科保存学会 秋季学術大会(第129回)
    • Place of Presentation
      富山市
    • Year and Date
      2008-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] IL-lαおよびIL-1βによるマウス骨芽細胞様細胞MC3T3-E1の動態におけるMAPK系の関与2008

    • Author(s)
      冨山高史, 成石浩司, 大森一弘, 久保克行, 前田博史, 新井英雄, 高柴正悟
    • Organizer
      第129回日本歯科保存学会 秋季学術大会
    • Place of Presentation
      富山市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット根管治療モデルを用いた根尖周囲組織の遺伝子マイクロアレイ解析に基づいた根尖病巣治癒病態の考察2008

    • Author(s)
      冨山高史, ら
    • Organizer
      日本歯科保存学会 春季学術大会(第128回)
    • Place of Presentation
      新潟市
    • Year and Date
      2008-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] ラツト根管治療モデルを用いた根尖周囲組織の遺伝子マイクロアレイ解析に基づいた根尖病巣治癒病態の考察2008

    • Author(s)
      冨山高史, 成石浩司, Zulema Arias, 山城圭介, 前田博史, 新井英雄, 高柴正悟
    • Organizer
      日本歯科保存学会 2008年春季学術大会(第128回)
    • Place of Presentation
      新潟市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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