Healing mechanism of rat experimental periapical lesions targeting laminin γ2 expression
| Project/Area Number |
20592226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
HATANAKA Kazu Okayama University, 大学院・医歯薬学総合研究科, 助教 (50362992)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tadashi 岡山大学, 岡山大学病院, 講師 (50432662)
TAKASHIBA Shougo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
SHIMOE Masayuki 岡山大学, 岡山大学病院, 医員 (60580264)
YAMAGUCHI Tomoko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90580267)
NARUISHI Koji 岡山大学, 岡山大学病院, 講師 (00346446)
KAKO Aya 岡山大学, 岡山大学病院, 医員 (60448230)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 根尖性歯周炎 / 骨芽細胞 / IL-1 / ラミニン / 病巣治癒 / インターロイキン1α / 根尖病巣 / 冶癒 / MAPK / インターロイキン1a / 細胞増殖活性 / 細胞接着活性 |
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| Research Abstract |
We have previously reported that cellular matrix laminin and inflammatory cytokine IL-1αgenes increased during periapical healing phase in a rat periapical periodontitis. In this study, we investigated the effect of these molecules to osteoblast that play a central role in bone formation. Our findings the enhancement of integrin α3 expression by IL-1α and the attachment of osteoblasts to laminin after stimulation with IL-1α suggest an important mechanism for adherence of osteoblasts in periapical healing.
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Report
(4 results)
Research Products
(12 results)
