| Project/Area Number |
20592228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
|
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAKANISHI Tadashi The University of Tokushima, 病院, 講師 (00217770)
|
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| Co-Investigator(Kenkyū-buntansha) |
YUMOTO Hiromichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60284303)
HOSOKAWA Yoshitaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90346601)
MUKAI Kayo 徳島大学, 病院, 助教 (30464340)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | カテキン / 歯髄炎 / 歯髄細胞 / 抗炎症作用 / サイトカイン / ケモカイン / シグナル伝達経路 |
|---|
| Research Abstract |
Caries progression induces pulp tissue to inflammation, which can develop pulpitis. The treatment for severe pulpitis is commonly pulpectomy, but it is thought that teeth stripped of pulp increased fracture risk in the future. The purpose of this study was development of the pulp preservation therapy using catechin, and we evaluated the effect of catechins on dental pulp cells stimulated with various bacteria-related factors. As a result, we showed that the catechins inhibited the expression of inflammatory factors in the dental pulp cells, and this finding suggested that they could be applied in the treatment of pulpitis.
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