| Project/Area Number |
20592229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUO Takashi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (30173800)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Kazumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90214121)
NAKAE Hideaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30227730)
SUGE Toshiyuki 徳島大学, 病院, 講師 (60243713)
HOSOKAWA Yoshitaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90346601)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 根面齲蝕 / ミュータンス菌 / 再石灰化 / 歯髄炎 / カテキン / 象牙細管侵入細菌 / 歯髄応答 / 自然免疫 / 病原体特異的分子パターン / パターン認識受容体 / 茶カテキン / 自然免疫機構 |
|---|
| Research Abstract |
In elderly people in Japan, the number of remaining teeth increases, however, root caries have been developed because of the exposure of the surface of the roots to the oral cavity. Hence, we investigated the virulence factors of S.mutans considered to be the cause of root caries. Also we investigated the pathogenesis of the early phase of pulpitis and examined the anti-inflammatory effects of tea catechin as a sedative medicament of pulpitis.
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