Clarification of role of smad regulating and promoting nodule formation in the dental pulp

• Project/Area Number: 20592239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Nihon University
• Principal Investigator: MATSUSHIMA Kiyoshi Nihon University, 松戸歯学部, 教授 (00157306)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯髄硬組織形成 / PGE2 / BMP / smad / レーザー照射 / 石灰化結節 / 歯髄組織 / 半導体レーザー照射 / 歯髄組 / 歯髄硬組織形成能 / PGE_2

Research Abstract

In order to widen the indications for conservative treatment of pulp, the purpose of this study was clarified the manner of smads which seem to facilitate the control of pulp nodule formation. During the addition of low concentration PGE2 to promote calcification, smad-7 was inhibited. Adding high concentration PGE2 to regulate calcification, smad-7 was enhanced. The laser irradiation to promote calcification is increased smad-1. The results suggested that to promote calcification smad-1 was enhanced and smad-7 was inhibited.

Research Products

• [Journal Article] 松井智, 小峯千明, 高橋知多香, 和田陽子, 岩井仁寿, 三浦浩, 辻本恭久, 池見宅司, 松島潔 (2010)
  • Author(s): 半導体レーザーの照射条件がヒト歯髄培養細胞の石灰化物形成能に及ぼす影響
  • Journal Title: 日本歯内療法学会誌 31 Pages: 71-78
  • Peer Reviewed
• [Journal Article] 半導体レーザーの照射条件がヒト歯髄培養細胞の石灰化物形成能に及ぼす影響 (2010)
  • Author(s): 松井智, 小峯千明, 高橋知多香, 和田陽子, 岩井仁寿, 三浦浩, 辻本恭久, 池見宅司, 松島潔
  • Journal Title: 日本歯内療法学会誌 Volume: 31 Pages: 71-78
  • NAID: 10026404473
  • Peer Reviewed
• [Journal Article] S.Matsui, C.Takahashi, Y.Tsujimoto, K.Matsushima (2009)
  • Author(s): Stimulatory Effects of Low-Concentration Reactive Oxygen Species on Calcification Ability of Human Dental Pulp Cells
  • Journal Title: Journal of Endodontics 35 Pages: 67-72
  • Peer Reviewed
• [Presentation] PGE2添加ヒト歯髄細胞の石灰化物形成におけるsmadsの動態 (2008)
  • Author(s): 坂本真樹、安念素代、富田敬、武内ひとみ、松島潔
  • Organizer: 第129回日本歯科保存学会
  • Place of Presentation: 富山国際会議場(富山)
  • Year and Date: 2008-11-06
• [Presentation] PGE_2添加ヒト歯髄細胞の石灰化物形成におけるsmadsの動態 (2008)
  • Author(s): 安念 素代
  • Organizer: 平成20年度日本歯科保存学会(第129回)
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-11-06