Basic Study of Direct Pulp Capping Materials

• Project/Area Number: 20592241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Nihon University
• Principal Investigator: HAYASHI Makoto Nihon University, 歯学部, 准教授 (00301557)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 直接覆髄剤 / 歯髄細胞 / 硬組織形成 / 細胞増殖 / アルカリフォスファターゼ / 骨芽細胞

Research Abstract

Dental pulp has many important roles, and the most severe problem of removing it would be tooth fracture. Therefore, dental treatment to preserve dental pulp is very important for dentists. The aim of this study is to develop new materials for direct pulp capping (i.e., treatment for protection of dental pulp). Five-aminoimidazole-4- carboxamide-1-β-4-ribofuranoside (AICAR), Titanium Medical Apatite (TMA), Calcium Phosphate Cement (CPC) were used to evaluate the possibility of being direct pulp capping materials in this study. Results indicated high biocompatibility and promotion of differentiation in some experimental conditions.

Research Products

• [Journal Article] In vitro and in vivo characteristics of fluorapatite-forming calcium phosphate cements (2010)
  • Author(s): S.Takagi, S.Frukhtbeyn, LC.Chow, A.Sugawara, K.Fujikawa, H.Ogata, M.Hayashi, B.Ogiso
  • Journal Title: J Res Natl Inst Stand Technol 115(4) Pages: 267-276
  • Peer Reviewed
• [Journal Article] A no-contact vibration device for measuring implant stability (2010)
  • Author(s): M.Hayashi, C.Kobayashi, H.Ogata, M.Yamaoka, B.Ogiso
  • Journal Title: Clin Oral Implants Res 21(9) Pages: 931-936
  • Peer Reviewed
• [Journal Article] Titanium Medical Apatite (TMA)真空焼結体が骨芽細胞に及ぼす影響 (2010)
  • Author(s): 林誠、田村賢一、小森規雄、小木曽文内、藤田龍之、森崎百合子
  • Journal Title: 日大歯学 84(3) Pages: 93-96
  • NAID: 10031146252
  • Peer Reviewed
• [Journal Article] 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside(AICAR)が培養ヒト歯髄由来細胞に及ぼす影響 (2010)
  • Author(s): 尾形英大、林誠、津田啓方、鈴木直人、小木曽文内
  • Journal Title: 日大歯学 84(3) Pages: 81-84
  • NAID: 10031146250
  • Peer Reviewed
• [Journal Article] In vitro and in vivo characteristics of fluorapatite-forming calcium phosphate cements (2010)
  • Author(s): S.Takagi
  • Journal Title: Journal of Research of the National Institute of Standards and Technology Volume: 115 Pages: 267-276
  • Peer Reviewed
• [Journal Article] A no-contact vibration device for measuring implant stability (2010)
  • Author(s): M.Hayashi
  • Journal Title: Clinical Oral Implant Research Volume: 21 Pages: 931-936
  • Peer Reviewed
• [Journal Article] Titanium Medical Apatite(TMA)真空焼結体が骨芽細胞に及ぼす影響 (2010)
  • Author(s): 林誠
  • Journal Title: 日大歯学 Volume: 84 Pages: 93-96
  • NAID: 10031146252
  • Peer Reviewed
• [Journal Article] 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside(AICAR)が培養ヒト歯髄由来細胞に及ぼす影響 (2010)
  • Author(s): 尾形英大
  • Journal Title: 日大歯学 Volume: 84 Pages: 81-84
  • Peer Reviewed
• [Presentation] Properties of Fluorapatite? forming Calcium Phos- phate Cements (2011)
  • Author(s): H.Ogata, S.Takagi, M.Hayashi, B.Ogiso, L.C.Chow
  • Organizer: 89^<th> General session & Exhibition of the IADR
  • Place of Presentation: San Diego, CA, USA
• [Presentation] In vivo characteristics of fluorapatite-forming CPCs for bone defect repair (2011)
  • Author(s): A.Sugawara, K.Fujikawa, M.Hayashi, H.Ogata, S.Iwata, B.Ogiso, S.Takagi, L.C.Chow
  • Organizer: 89^<th> General session & Exhibition of the IADR
  • Place of Presentation: San Diego, CA, USA
• [Presentation] In-vivo characteristics of fluorapatite-forming CPC when implanted in subcutaneous tissues (2011)
  • Author(s): K.Fujikawa, A.Sugawara, M.Hayashi, H.Ogata, B.Ogiso, M.Oki, S.Takagi, L.C.Chow
  • Organizer: 89th General session & Exhibition of the IADR
  • Place of Presentation: San Diego, CA, USA
• [Presentation] In-vivo characteristics of fluorapatite-forming CPC when implanted in subcutaneous tissues (2011)
  • Author(s): K.Fujikawa
  • Organizer: 89^<th> General session & Exhibition of the IADR
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Comparative studies of P-CPC and conventional endodontic cements on mineralization (2010)
  • Author(s): 林誠
  • Organizer: The American Association for Dental Research
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2010-03-05
• [Presentation] Histopathological study of dual-paste premixed CPC used for bone defect (2010)
  • Author(s): 林誠
  • Organizer: The American Association for Dental Research
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2010-03-05
• [Presentation] Histopathological and x-ray micro-CT studies of premixed CPC for bone-graft (2010)
  • Author(s): 林誠
  • Organizer: The American Association for Dental Research
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2010-03-05
• [Presentation] Effect of implant's mass on measurement of mechanical parameters analyzed by a no-contact electromagnetic vibration device (2010)
  • Author(s): M.Hayashi, C.Kobayashi, M.Yamaoka, T.Saito, B.Ogiso
  • Organizer: World Congress for Oral Implantology 8
  • Place of Presentation: New Delhi, India
• [Presentation] Assessing qualitative changes in periodontal ligament using no-contact vibration device (2010)
  • Author(s): C.Kobayashi, M.Hayashi, M.Yamaoka, B.Ogiso
  • Organizer: 88^<th> General session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
• [Presentation] Comparative studies of P-CPC and conventional endodontic cements on mineralization (2010)
  • Author(s): H.Ogata, M.Hayashi, H.Tsuda, N.Suzuki, A.Sugawara, S.Takagi, L.C.Chow, M.Maeno, B.Ogiso
  • Organizer: 39^<th> Meeting of the AADR
  • Place of Presentation: Washington DC, USA
• [Presentation] Histopathological study of dual-paste premixed CPC used for bone defect (2010)
  • Author(s): K.Fujikawa, A. Sugawara, H.Ogata, M.Hayashi, S.Hirayama, K.Sakai, K.Inoue, S.Takagi, L.C.Chow
  • Organizer: 39^<th> Meeting of the AADR
  • Place of Presentation: Washington DC, USA
• [Presentation] Histopathological and x-ray micro-CT studies of premixed CPC for bone-graft (2010)
  • Author(s): A.Sugawara, K.Fujikawa, M.Hayashi, H.Ogata, M.Oki, B.Ogiso, S.Takagi, L.C.Chow
  • Organizer: The 39^<th> Meeting of the AADR
  • Place of Presentation: Washington DC, USA
• [Presentation] Properties of Fluorapatite-forming Calcium Phosphate Cements (2010)
  • Author(s): H.Ogata
  • Organizer: 89^<th> General session & Exhibition of the IADR
  • Place of Presentation: San Diego, CA, USA
• [Presentation] リン酸カルシウムセメントは骨芽細胞に対して生体親和性を有する、日本歯科保存学会 (2009)
  • Author(s): 尾形英大、林誠、津田啓方、鈴木直人、菅原明喜、高木章三、Laurence C.CHOW、小木曾文内
  • Organizer: 第130回春季学術大会
  • Place of Presentation: 札幌コンベンションセンター(札幌)
  • Year and Date: 2009-06-12
• [Presentation] リン酸カルシウムセメントは骨芽細胞に対して生体親和性を有する (2009)
  • Author(s): 林誠
  • Organizer: 日本歯科保存学会2009年度春季学術大会(第130回)
  • Place of Presentation: 札幌コンベンションセンターSORA(北海道)
  • Year and Date: 2009-06-12
• [Presentation] 自己硬化性リン酸カルシウムの骨芽細胞に対する生体親和性について (2009)
  • Author(s): 尾形英大、林誠、津田啓方、鈴木直人、菅原明喜、高木章三、Laurence C.CHOW、小木曾文内
  • Organizer: 第61回日本大学歯学会総会・学術大会
  • Place of Presentation: 日本大学歯学部・大講堂(東京)
  • Year and Date: 2009-05-16
• [Presentation] 自己硬化性リン酸カルシウムの骨芽細胞に対する生体親和性について (2009)
  • Author(s): 林誠
  • Organizer: 第61回日本大学歯学会総会・学術大会
  • Place of Presentation: 日本大学歯学部(東京)
  • Year and Date: 2009-05-16
• [Presentation] Biocompatibility of novel vacuum sintered bodies of titanium medical apatite (2008)
  • Author(s): M.Hayashi, H.Ogata, N.Suzuki, N.Komori, O.Takeichi, K.Tamura, Y.Morisaki, B.Ogiso, T.Fujita
  • Organizer: 86^<th> General session & Exhibition of the IADR
  • Place of Presentation: Toronto, Canada
• [Book] WCOI Year Book 2010(Edited by World Congress for Oral Implantology)(The biocompatibility of novel apatite chemically bonded with titanium dioxide as potential bone substitute) (2010)
  • Author(s): M.Hayashi, K.Tamura, N.Komori, B.Ogiso, T.Fujita, Y.Morisaki
  • Publisher: Editorial Committee
• [Book] WCOI Year Book 2010 In : The biocompatibility of novel apatite chemically bonded with titanium dioxide as potential bone substitute (2010)
  • Author(s): M.Hayashi
  • Publisher: World Congress for Oral Implantology, Editorial Committee