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Expression of MMPs and TIMPS in development of rat periradicular lesion

Research Project

Project/Area Number 20592243
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

IMAIZUMI Ichiro  Aichi Gakuin University, 歯学部, 講師 (20308779)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Hiroshi  愛知学院大学, 歯学部, 教授 (40064878)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords根尖病変 / MMP-8 / MMP-13 / TIMP1 / TIMP2 / MMP-1 / MMMP-13
Research Abstract

To elucidate the expressions of MMP-8, MMP-13,TIMP1 and TIMP2 in experimentally induced rat periradicular lesions by means of the reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical staining.
These findings indicate that MMP-8, MMP-13,TIMP1 and TIMP2 were related to the development of periradicular lesions.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Expression of MMP-8 and MMP13 in the deveropment of periradicular lesions2011

    • Author(s)
      H.Matsui, M.Yamasaki, K.Nakata, K.Amano, H.Nakamura
    • Journal Title

      International Endodontic Journal (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] ラット根尖病変の成立過程におけるメタロプロテアーゼの発現2010

    • Author(s)
      田中毅、川合里絵、松井寛敬、天野一晴、今泉一郎、中村洋
    • Organizer
      日本歯科保存学会2010年度秋季学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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