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Application of calcium phosphate cement containing bioactive glasses for endodontic therapy

Research Project

Project/Area Number 20592248
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

IZUMI Toshio  Fukuoka Dental College, 歯学部, 准教授 (40248547)

Co-Investigator(Kenkyū-buntansha) ANAN Hisashi  福岡歯科大学, 歯学部, 教授 (80158732)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsリン酸カルシウムセメント / bioactive glass / 覆髄材 / 骨補填材 / Bioactive glass / apoptosis / 大食球
Research Abstract

The dentin bridge formation was observed when a new calcium phosphate cement (CPC) that contained bioactive glasses was used as a pulp capping agent. And there was no significant difference in the ability of dentin bridge formation between the new CPC and a calcium hydroxide. Some apoptic cells were observed in the pulp during dentin bridge formation. It was suggested that about 60% of apoptic cells should be monocytes/macrophages, which contained TUNEL+ nucleus, and the rest should be pulp cells. The new CPC did not make a significant difference in the new bone formation compared with hydroxyapatite as a bone grafting material.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Pro-inflammatory cytokines induce suppressor of cytokine signaling-3 in human periodontal ligament cells2010

    • Author(s)
      Fukushima A, Kajiya H, Izumi T, Shigeyama C, Okabe K, Anan H
    • Journal Title

      J Endod vol.36

      Pages: 1004-1008

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯髄創傷治癒に及ぼすエムドゲインゲルの影響2010

    • Author(s)
      阿南壽、松本典祥、泉利雄, 他
    • Journal Title

      福岡歯科大学学会雑誌 36巻

      Pages: 1-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PTHrP induces Notch signaling in periodontal ligament cells2009

    • Author(s)
      Nakao A, Kajiya H, Fukushima H, Fukushima A, Anan H, others
    • Journal Title

      J Dent Res vol.88

      Pages: 551-556

    • Related Report
      2010 Final Research Report
    • Peer Reviewed

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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