Detection of nano-controlled molecular interaction of functional monomers at adhesive interfaces for hard tissue reconstruction

• Project/Area Number: 20592250
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Junsei Junior College
• Principal Investigator: NAKAMURA Mariko Junsei Junior College, 短期大学部・保健科, 教授 (90284067)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Yasuhiro 岡山大学, 医歯薬学総合研究科, 准教授 (90281162)
• Co-Investigator(Renkei-kenkyūsha): SHIBAHARA Takashi 岡山理科大学, 理学部, 教授 (30122386) ; SAKANE Genta 岡山理科大学, 理学部, 講師 (90278911)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アパタイト / 機能性モノマー / 歯質接着界面 / 分子挙動 / 象牙質 / MDP / Phenyl-P / 4-MET

Research Abstract

Although decayed/fractured teeth can be reconstructed minimally invasively and nearly invisibly using adhesive technology, the clinical longevity of dental composite restorations is still too short. Water sorption is thought to be the principal cause of destabilization of the biomaterial-tooth bond. However, the actual mechanisms of interfacial degradation are far from understood. Here we report how nano-controlled molecular interaction at the biomaterial-hard tissue interface can improve bond durability. The use of functional monomers with a strong chemical affinity for the calcium in hydroxyapatite is essential for long-term durability. Correlative X-ray diffraction and solid-state nuclear magnetic resonance disclosed a time-dependent molecular interaction at the interface with stable ionic bond formation of the monomer to hydroxyapatite competing in time with the deposition of less stable calcium phosphate salts. The advanced tooth-biomaterial interaction model gives not only an insight into the mechanisms of bond degradation, but also provides a basis to develop functional monomers for more durable tooth reconstruction.

Research Products

• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstructionActa Biomaterialia (2010)
  • Author(s): Yoshihara K, Yoshida Y, Nagaoka N, Fukegawa D, Hayakawa S, Mine A, Nakamura M, Minagi S, Osaka A, Suzuki K, Van Meerbeek B
  • Journal Title: Vol.6 Pages: 3573-3582
  • Peer Reviewed
• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction (2010)
  • Author(s): Yoshihara K, Yoshida Y, Nagaoka N, Fukegawa D, Hayakawa S, Mine A, Nakamura M, Minagi S, Osaka A, Suzuki K, Van Meerbeek B.
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 3573-3582
  • Peer Reviewed
• [Presentation] 生体硬組織/材料ナノ界面の形成メカニズムの解明と接着耐久性への影響 (2009)
  • Author(s): 中村真理子
  • Organizer: 高梁学園学術交流コンファレンス
  • Place of Presentation: 延岡
  • Year and Date: 2009-03-08