| Project/Area Number |
20592255
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KUBO KEI Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (10431511)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Keiichi 東北大学, 大学院・歯学研究科, 教授 (30178644)
YOKOYAMA Masayoshi 東北大学, 大学院・歯学研究科, 助教 (20396500)
土井 直洋 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (00466533)
船木 善仁 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (50261491)
池田 清宏 東北大学, 大学院・工学研究科, 教授 (50168126)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インプラント / 骨代謝 / 定量評価 / PET / FEM |
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| Research Abstract |
This study aimed to examine the influence of early loading on dynamic changes of bone metabolism around dental implants by using a Fine PET. Two titanium implants were inserted in the right tibiae of Wistar rats. 1 day after insertion, closed coil springs with 4.0 N were applied to the implants. The rats with 18F-(5mCi/rat) intravenously-injected were scanned by PET scanner at 4, 7, 14, 28 days after load application. Round ROIs were set around the distal implant (right tibia) and at the intact side (left tibia). Longitudinal dynamic changes in bone metabolism were evaluated by examination of the accumulation count of 18F-at each ROI. The results shows that early loading to the implant initially enhanced the bone metabolism around the implant, however, metabolic activity returned to pre-loading level with time despite a static force being applied to the implants.
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