| Project/Area Number |
20592294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
|
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| Research Institution | Osaka Dental University |
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Principal Investigator |
KUREMOTO Koh-Ichi Osaka Dental University, 歯学部, 助教 (90319583)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MAEDA Teruta 大阪歯科大学, 歯学部附属病院, 教授 (10103110)
|
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAZA Takayoshi 九州大学, 歯学部, 助教 (80304814)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
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| Keywords | FGF / 歯髄幹細胞 / 象牙質再生 |
|---|
| Research Abstract |
Rodent incisors regenerate throughout the animal lifetime as a result of the continuous deposition of enamel, the hardest component of the tooth, by ameloblasts. Putative dental epithelial stem cells (DESCs) reside at the base of the incisors in a structure called the cervical loop (CL). The DESCs can self renew and give rise to ameloblast progenitor cells (APCs), which proliferate and differentiate into ameloblasts producing enamel. In this study, we explored the role of Fibroblast Growth Factor Receptor 2b (FGFR2b) signaling during incisor homeostasis in the adult mice. FGFR2b signaling plays a critical role in the regenerative capacity of adult incisors by controlling the proliferation of transit amplifying APCs, but not by regulating the survival of DESCs.
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