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Development of implant surface modification method for rapid osteoconductivity and gingival epithelial adhesiveness

Research Project

Project/Area Number 20592301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionKyushu University

Principal Investigator

NAKAGAWA Masaharu  Kyushu University, 歯学研究院, 准教授 (80172279)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsチタン / インプラント / 上皮歯肉付着性 / 骨結合性 / 表面改質処理 / 歯肉上皮細胞(GE1) / 骨結合強度
Research Abstract

Initial cell attachment and cell proliferation were examined by using gingival epithelial cell (GE1) of mouse origin to examine adhesiveness of epithelial cell of implant in gingival penetration part. As for the titanium treated by hydrothermally in calcium chloride solution, the result of initial attachment of GE1 cell was significantly high compared with untreated titanium. As for the cell proliferation, a significant difference was not admitted though the untreated titanium indicated some high values. Therefore, it was suggested that the hydrothermal treatment with CaCl2 was able to improve the gingiva adhesiveness in the gingiva penetration part of the titanium implant.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Effect of CaCl2 hydrothermal treatment on the bone bond strength and osteoconductivity of Ti-0.5Pt and Ti-6Al-4V-0.5Pt alloy implants2009

    • Author(s)
      Masaharu Nakagawa, Jyunichi Yamazoe
    • Journal Title

      Journal of Materials Science : Materials in Medicine 20

      Pages: 2295-2303

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of CaCl2 hydrothermal treatment on the bone bond strength and osteoconductivity of Ti-0.5Pt and Ti-6Al-4V-0.5Pt alloy2009

    • Author(s)
      M.Nakagawa, J.Yamazoe
    • Journal Title

      Journal of Materials Science : Materials in Medicine 20

      Pages: 2295-2303

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Corrosion Behavior of Pure Titanium and Titanium Alloy on Fluoride Addition in Acidic Environment by Streptococcus mutans2008

    • Author(s)
      Yoshinari Matono, Masaharu Nakagawa, Kunio Ishikawa, Yoshihiro Terada
    • Journal Title

      Prosthodont Research &amp ; Practice 7

      Pages: 34-39

    • NAID

      130006962843

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of molding pressure on fabrication of low-crystalline calcite block2008

    • Author(s)
      Xin Lin, Shigeki Matsuya, Masaharu Nakagawa, Yoshihiro Terada, Kunio Ishikawa
    • Journal Title

      Journal of Materials Science : Materials in Medicine 19

      Pages: 479-484

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of Corrosion Behavior of Pure Titanium and Titanium Alloy on Fluoride Addition in Acidic Environment by Streptococcus mutans.2008

    • Author(s)
      Yoshinari Matono, Masaharu Nakagawa, et al.
    • Journal Title

      Prosthodont Research & Practice 7

      Pages: 34-39

    • NAID

      130006962843

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Fibroblasts Attachment to CaCl2 Hydrothermally Treated Titanium Implant2011

    • Author(s)
      W.ELSHAHAWY, I.WATANABE, M.NAKAGAWA, P.R.KRAMER
    • Organizer
      IADR/AADR/CADR 89th General Session and Exhibition
    • Related Report
      2010 Final Research Report
  • [Presentation] Fibroblasts Attachment to CaCl2 Hydrothermally Treated Titanium Implant2011

    • Author(s)
      W.ELSHAHAWY, I.WATANABE, M.NAKAGAWA, 他
    • Organizer
      The IADR/AADR/CADR 89th General Session and Exhibition
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Surface modification of polyethylene terephthalate (PET) substrates for biomedical application by ozone-calcium chloride treatment2010

    • Author(s)
      Ahmed Nafis Rashid, Masaharu Nakagawa, Kanji Tsuru, Giichiro Kawachi, Michito Maruta, Shigeki Matsuya, Kunio ishikawa
    • Related Report
      2010 Final Research Report
  • [Presentation] Studies on Improving Osteoconductivity of Titanium by Hydrothermal Treatment2009

    • Author(s)
      L.Zhang, M.Nakagawa, 他
    • Organizer
      The 2nd Meeteng if IADR Pan Asian Pacific Federation(PAPF)and the 1^<st> Meeting of IADR ASIA/Pasific Region(APR)
    • Place of Presentation
      Wuhan(China)
    • Year and Date
      2009-09-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Studies on Improving Osteoconductivity of Titanium by Hydrothermal Treatment2009

    • Author(s)
      L.Zhang, M.Nakagawa, L Cong, J.Chen, Y.Ayukawa, R.Z.Legeros, S.Matsuya, K.Koyano, K Ishikawa
    • Organizer
      The 2nd Meeteng if IADR Pan Asian Pacific Federation (PAPF) and the 1st Meeting of IADR ASIA/Pasific Region (APR)
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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