| Project/Area Number |
20592311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
|
|---|
| Research Institution | Tokyo Dental College |
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Principal Investigator |
YAJIMA Yasutomo Tokyo Dental College, 歯学部, 教授 (10183667)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Taichi 東京歯科大学, 歯学部, 講師 (80312015)
FURUYA Yoshitaka 東京歯科大学, 歯学部, 助教 (80385179)
HOMMA Shinya 東京歯科大学, 歯学部, 助教 (70408334)
SASAKI Hodaka 東京歯科大学, 歯学部, 助教 (50433959)
SUZUKI Norihisa 東京歯科大学, 歯学部, レジデント (50453767)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯学 / インプラント / 癌 / 発癌率 / 口腔粘膜 |
|---|
| Research Abstract |
Recently age of implant patients become elderly, correspond to a peak age of onset of oral carcinoma. From the concept of "field cancerization", we hypothesized that peri-implant mucosa had higher cancer risk than oral mucosa, because it was chronically infected by various stimulation. The aim of this study was to examine the correlation between peri-implant mucosa and oral cancer pathogenesis using 4NQO-induced carcinogenesis experimental rat model.
After 6 month 4NQO administration, it was not observed carcinoma in peri-implant mucosa. However, some atypical cells (high N/C ratio, nuclear pleomorphism) were recognized in it than control group. From these results, it was suggested peri-implant epithelium has high potential of canceration, and it will be clarified by long-term observation.
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