| Project/Area Number |
20592320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANNO Yuki The University of Tokyo, 医学部附属病院, 助教 (80451813)
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| Co-Investigator(Kenkyū-buntansha) |
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
YANO Fumiko 東京大学, 大学院・医学系研究科, 特任助教 (80529040)
近津 大地 東京大学, 医学部附属病院, 助教 (30343122)
大橋 克巳 東京大学, 医学部・附属病院, 助教 (60233235)
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| Co-Investigator(Renkei-kenkyūsha) |
OGATA Naoshi 東京大学, 医学部附属病院, 講師 (10361495)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 顎顔面 / 骨再生 / PTHシグナル / β-catenin / PTH / PTH/PTHrP受容体 / PTHrP受容体 / βカテニン / 骨形成 / 顎顔面骨再生 / G蛋白 / Wntシグナル |
|---|
| Research Abstract |
The purpose of this study is to clarify regulatory mechanism of bone metabolism and its effect via interaction between PTH signaling, that has anabolic effect in bone, and β-catenin binding to PTH/PTHrP receptors. By elucidating osteogenic function via the interaction, we aim to develop PTH-related osteogenesis-accelerating drugs that are more effective with less side-effect.
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