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Clarification of interaction between β-catenin and PTH in osteogenesis for craniofacial bone regeneration

Research Project

Project/Area Number 20592320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokyo

Principal Investigator

KANNO Yuki  The University of Tokyo, 医学部附属病院, 助教 (80451813)

Co-Investigator(Kenkyū-buntansha) OGASAWARA Toru  東京大学, 医学部附属病院, 講師 (20359623)
YANO Fumiko  東京大学, 大学院・医学系研究科, 特任助教 (80529040)
近津 大地  東京大学, 医学部附属病院, 助教 (30343122)
大橋 克巳  東京大学, 医学部・附属病院, 助教 (60233235)
Co-Investigator(Renkei-kenkyūsha) OGATA Naoshi  東京大学, 医学部附属病院, 講師 (10361495)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords顎顔面 / 骨再生 / PTHシグナル / β-catenin / PTH / PTH/PTHrP受容体 / PTHrP受容体 / βカテニン / 骨形成 / 顎顔面骨再生 / G蛋白 / Wntシグナル
Research Abstract

The purpose of this study is to clarify regulatory mechanism of bone metabolism and its effect via interaction between PTH signaling, that has anabolic effect in bone, and β-catenin binding to PTH/PTHrP receptors. By elucidating osteogenic function via the interaction, we aim to develop PTH-related osteogenesis-accelerating drugs that are more effective with less side-effect.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2010 2009 2008 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (16 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Enhancement of boneformation ex vivo and in vivo by a helioxanthin-derivative.2010

    • Author(s)
      Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N,Ihara S, Aburatani H, Takato T, Chung UI
    • Journal Title

      Biochem Biophys Res Commun. 395(4)

      Pages: 502-508

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trehalose inhibits oral dryness by protecting the cell membrane.2010

    • Author(s)
      Mori Y, Yano F, Shimohata N, Suzuki S, Chung UI, Takato T.
    • Journal Title

      Int J Oral Maxillofac Surg. 39(9)

      Pages: 916-921

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-induced osteomalacia associated with a maxillofacial tumor producing fibroblast growth factor 23 : report of a case and review of the literature.2010

    • Author(s)
      Mori Y, Ogasawara T, Motoi T, Shimizu Y, Chikazu D, Tamura K, Fukumoto S, Takato T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109(3)

      Pages: 57-63

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A bone harvesting method involving a surgical template prepared using a three-dimensional model2010

    • Author(s)
      Saijo H, Kanno Y, Mori Y, Chikazu D, Iino M, Takato T.
    • Journal Title

      Asian.J. Oral.Maxillofac.Surg. 22

      Pages: 20-22

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation and analysis of bone formation at palate of cleft lip and palate patients after palatoplasty based on computed tomographic scanning and three dimensional data.2010

    • Author(s)
      Saijo H, Mori Y , Kanno Y, Chikazu D, Fujihara H, Ohkubo K, Hikiji H, Iino S, Yonehara Y, Takato T
    • Journal Title

      Journal of Plastic Surgery & Hand Surgery 44

      Pages: 21-25

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.2010

    • Author(s)
      Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H.
    • Journal Title

      Nat Med. 16(6)

      Pages: 678-686

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Runx1 and Runx2 cooperate during sternal morphogenesis.2010

    • Author(s)
      Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S.
    • Journal Title

      Development. 137(7)

      Pages: 1159-67

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.2010

    • Author(s)
      Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI.
    • Journal Title

      J Bone Miner Metab. 28(6)

      Pages: 627-33

    • NAID

      10027845798

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions.2010

    • Author(s)
      Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa A, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H.
    • Journal Title

      Arthritis Rheum. 62(3)

      Pages: 826-836

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A bone harvesting method involving a surgical template prepared using a three-dimensional model2010

    • Author(s)
      Saijo H, et al.
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery

      Volume: 22 Pages: 20-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.2010

    • Author(s)
      Saito T, et al.
    • Journal Title

      Nat Med.

      Volume: 16 Pages: 678-686

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development.2010

    • Author(s)
      Hojo H, et al.
    • Journal Title

      J Bone Miner Metab.

      Volume: 28 Pages: 489-502

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming Growth Factor-β1 in Combination with Fibroblast Growth Factor-2 and Insulin-like Growth Factor-I for Chondrocyte Proliferation Culture and Cartilage Regenerative Medicine.2009

    • Author(s)
      Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung UI, Yoda T, Mori Y, Susami T, Takato T, Hoshi K.
    • Journal Title

      Asian J Oral Maxillofac Surg. 21

      Pages: 18-26

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional shape control of implant devices2009

    • Author(s)
      Chung U-I, et al.
    • Journal Title

      The Handbook of Intelligent Scaffold for Regenerative Medicine (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology2009

    • Author(s)
      Saijo H, et al.
    • Journal Title

      J Artif Organs 12

      Pages: 200-205

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A bone harvesting method involving a surgical template prepared using a three-dimensional model2009

    • Author(s)
      Saijo H, et al.
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of high-throughput screening system for osteogenicdrugs using a cell-based sensor.2008

    • Author(s)
      Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y,Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI.
    • Journal Title

      Biochem Biophys Res Commun. 376(2)

      Pages: 375-379

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of tumoural calcinosis in the temporomandibular joint associated with systemic sclerosis.2008

    • Author(s)
      Daichi Chikazu et al.,
    • Journal Title

      Int J Oral Maxillofac Surg 37

      Pages: 190-193

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of transforming growth factor (TGF)-β1 in combination with fibroblast growth factor (FGF)-2 and insulin-like growth factor (IGF)-I on chondrocytes proliferation culture for the cartilage regenerative medicine2008

    • Author(s)
      Toru Ogasawara et al.,
    • Journal Title

      Asian J Oral Maxillofac Surg (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patchedl haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008

    • Author(s)
      Shinsuke Ohba et al.,
    • Journal Title

      Dev Cell 14

      Pages: 689-699

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] A novel method for designing and fabricating custom-made artificial bones.2010

    • Author(s)
      Kanno Y, Takato T, Saijo H, Igawa K, Seto I, Mori Y, Ohkubo K, Sasaki N, Suzuki S, Chung UI.
    • Organizer
      Bernd-Spiessl-Symposium 2010
    • Place of Presentation
      Basel,Switzerland.
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] A novel method for designing and fabricating custom-made artificial bones.2010

    • Author(s)
      Yuki Kanno, et al.
    • Organizer
      Bernd-Spiessl Symposium
    • Place of Presentation
      バーゼル大学(スイス、バーゼル)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] カスタムメイド人工骨移植後の骨癒合状態の評価2010

    • Author(s)
      菅野勇樹,西條英人,井川和代,斉藤健太郎,瀬戸一郎,森良之,高戸毅
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      幕張メッセリンク,千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] 両側顎関節強直症に対し、人工下顎頭を応用した1例2010

    • Author(s)
      菅野勇樹、西條英人、斎藤健太郎、宇波雅人、大久保和美、近津大地、森良之、高戸毅
    • Organizer
      第64回NPO法人日本口腔科学会学術大会
    • Place of Presentation
      札幌プリンスホテル,北海道
    • Related Report
      2010 Final Research Report
  • [Presentation] カスタムメイド人工骨移植後の移植位置評価2009

    • Author(s)
      菅野勇樹, ら
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 進行性骨化性線維異形成症(FOP)患者に対する全身麻酔下での抜歯経験2009

    • Author(s)
      森良之,須佐美隆史,西條英人,菅野勇樹,近津大地,末永英之,杉山円,前田祐二郎,斎藤健太郎,飯野光喜,高戸毅
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター,北海道
    • Related Report
      2010 Final Research Report
  • [Presentation] カスタムメイド人工骨移植後の移植位置評価2009

    • Author(s)
      菅野勇樹,西條英人,井川和代,大久保和美,近津大地,森良之,飯野光喜,鄭雄一,高戸毅
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター,北海道
    • Related Report
      2010 Final Research Report
  • [Presentation] βカテニンは軟骨細胞のPTH/PTHrP受容体の細胞内ドメインに直接結合して肥大分化を制御する2009

    • Author(s)
      矢野文子,鄭雄一,池田敏之,斎藤琢,高戸毅,中村耕三,川口浩,緒方直史
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場,大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞周期制御を利用した骨粗鬆症治療法開発のための基礎的検討2009

    • Author(s)
      小笠原徹,高戸毅
    • Organizer
      第9回日本抗加齢医学会総会
    • Place of Presentation
      ホテル日航東京,東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 上顎洞底挙上術時に洞粘膜の穿孔を合併した1例2008

    • Author(s)
      菅野勇樹,西條英人,藤原久子,斎藤健太郎,田中庸子,杉山円,前田祐二郎,飯野光喜,高戸毅
    • Organizer
      第12回日本顎顔面インプラント学会総会・学術集会
    • Place of Presentation
      日本歯科大学,東京
    • Related Report
      2010 Final Research Report
  • [Presentation] GαqシグナルはPKCδを介してPTHの骨同化作用を抑制する2008

    • Author(s)
      緒方直史,矢野文子,鄭雄一,中村耕三,川口浩
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場,大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規低分子化合物チエノインダゾール誘導体はRunx1とSox trioを介して永久軟骨再生を誘導する2008

    • Author(s)
      矢野文子,池田敏之,斎藤琢,緒方直史,木村文子,竹田秀,中村耕三,高戸毅,川口浩,鄭雄一
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場,大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] β-catenin Directly Binds to a Specific Intracellular Domain of PTH/PTHrP Receptor and Regulates the Signaling in Chondrocytes during Endochondral Ossification.2008

    • Author(s)
      Yano F, Chung UI, Ikeda Y, Kawasaki Y, Kawaguchi H, Tawfeek H, Mahon M.J, Segre G.V, Ogata N
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research.
    • Place of Presentation
      Convention Center Montreal, Quebec, Canada.
    • Related Report
      2010 Final Research Report
  • [Presentation] Inhibitory role of Gαq/PKCαsignal in the bone anabolic action of PTH.2008

    • Author(s)
      Ogata N, Yano F, Chung UI, NWettschureck N., Offermanns S., Segre G.V., Nakamura K., Kawaguchi K.
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research.
    • Place of Presentation
      Convention Center Montreal, Quebec, Canada.
    • Related Report
      2010 Final Research Report
  • [Presentation] 下顎骨半側切除後のプレート再建に三次元立体モデルによりシミュレーションを施行した1例2008

    • Author(s)
      菅野勇樹,西條英人,森良之,末永英之,山田陽子,前田祐二郎,近津大地,飯野光喜,高戸毅
    • Organizer
      第62回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場,福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology2008

    • Author(s)
      Yuki Kanno et al.,
    • Organizer
      8th Asia Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Bangkok
    • Related Report
      2008 Annual Research Report
  • [Book] 医師・歯科医師のための口腔診療必携2010

    • Author(s)
      小笠原徹, ら
    • Total Pages
      263
    • Publisher
      金原出版株式会社
    • Related Report
      2010 Annual Research Report
  • [Remarks] 東京大学医学部附属病院顎口腔外科・歯科矯正歯科ホームページ

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/%7Eoralsurg/archive.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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