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An experimental study on histologic changes of osteogenesis and neurogenes is followed by osteoplasty of the mandible

Research Project

Project/Area Number 20592323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKanazawa University

Principal Investigator

NAKAGAWA Kiyomasa  Kanazawa University, 医学系, 准教授 (30155676)

Co-Investigator(Renkei-kenkyūsha) TAKATSUKA Shigeyuki  金沢大学, 附属病院, 講師 (00251926)
UEKI Kouichirou  金沢大学, 医学系, 助教 (40313663)
MARUKAWA Kouhei  金沢大学, 附属病院, 医員 (50444203)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords顎変形症 / 顎矯正手術 / 知覚神経麻痺 / 三叉神経感覚誘発電位 / 骨切り術 / 骨 / 神経
Research Abstract

An experimental study of the postoperative changes on neurogenesis and neurogenic physiology has been carried out using rabbits. Purpose of the study was focused on microscopic changes in surgical sites of the saggital split osteotomy and distraction osteogenesis of the mandible. Experimental animals have divided into four groups. Osteogenesis and neurogenesis followed by surgical maneuver was evaluated histopathologically. Analyses have performed on distribution of osteogenic cells such as osteoblast and osteoclast, or bone morphogenetic protein (BMP) using histo-chemical methods. Results of the study have suggested that experimental groups showed consistent healing compared to sham control following both sagittal split osteotomy and distraction osteogenesis, irrespective of difference of the healing time.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (10 results)

  • [Journal Article] Etsuhide Yamamoto Position of mandibular canal and ramus morphology before and after saggital split ramus osteotomy2010

    • Author(s)
      Koichiro Ueki, Katsuhiko Okabe, Mao Miyazaki, Aya Mukozawa, Kohei Marukawa, Kiyomasa Nakagawa
    • Journal Title

      J Oral Maxillofac Surg 68

      Pages: 1795-1801

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An experimental study of use of absorbable plate in combination with self-setting alpha-tricalcium phosphate for orthognathic surgery2010

    • Author(s)
      Katsuhiko Okabe, Koichiro Ueki, Kohei Marukawa, Aya Mukozawa, Mao Miyazaki, Kiyomasa Nakagawa
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 110

      Pages: 560-569

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Position of mandibular canal and ramus morphology before and after saggital split ramusos teotomy2010

    • Author(s)
      Ueki k, nakagawa K, et al
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 68 Pages: 1795-1801

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress change on the temporom and ibular joint in mandibular prognathism subjects with asymmetry after orthognathic surgery2010

    • Author(s)
      Ueki k, nakagawa K, et al
    • Journal Title

      Eur J Orthod

      Volume: 32 Pages: 522-529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skelet al stability after mandibular setback surgery comparisons among unsintered hydroxyapatite/pro-1-lacticacidplate, and titanium plate2010

    • Author(s)
      Ueki k, nakagawa K, et al
    • Journal Title

      J Oral Maxillofac Surg

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of bone formation after sagittal split ramus osteotomy with bent plate fixation using computed tomography2009

    • Author(s)
      Koichiro Ueki, Yukari Hashiba, Kohei Marukawa, Katsuhiko Okabe, Kiyomasa Nakagawa Shamiul Alam, Etsuhide Yamamoto
    • Journal Title

      J Oral Maxillofac Surg 67

      Pages: 1062-1068

    • NAID

      120001342279

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natthiya Sakulsak, Shoichi Iseki Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration : an immunohistochemical study2009

    • Author(s)
      Shamiel Alam, Koichiro Ueki, Kiyomasa Nakagawa, Kohei Marukawa Yukari Hashiba, Etsuhide Yamamoto
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107

      Pages: 22-29

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Statin-induced bone morphogenetic protein(BMP)2 expression during bone regeneration : an immunohistochemical study2009

    • Author(s)
      Alam S, Ueki K, Nakagawa K, et al
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107

      Pages: 22-29

    • NAID

      120001063577

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of changing position and angle of the proximal segment after intraoral vertical ramus osteotomy2009

    • Author(s)
      Ueki K, Hashiba Y, Nakagawa K, et al
    • Journal Title

      Int J Oral Maxillofac Surg 38

      Pages: 1041-1047

    • NAID

      120001643239

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of ramus, condyle, masseter muscle, and occlusal force before and after sagittal split ramus osteotomy in patients with mandibular prognathism2009

    • Author(s)
      Ueki K, Okabe K, Nakagawa K, et al
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108

      Pages: 679-686

    • NAID

      120001507841

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The evaluation of surgical factors related to recovery period of upper lip hypoaesthesia after Le Fort I osteotomy2008

    • Author(s)
      Koichiro Ueki, Yukari Hashiba, Kohei Marukawa, Kiyomasa Nakagawa, Shamiel Alam, Etsuhide Yamamoto
    • Journal Title

      J Cranio-Maxillofac Surg 36

      Pages: 390-394

    • NAID

      120001130406

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Etsuhide Yamamoto Assessment of the relationship between the recovery of maximum mandibular opening and the maxillomandibular fixation period after orthognathic surgery2008

    • Author(s)
      Koichiro Ueki, Kohei Marukawa, Yukari Hashiba, Kiyomasa Nakagawa, Kagan Degerliyurt, Etsuhide Yamamoto
    • Journal Title

      J Oral Maxillofac Surg 66

      Pages: 486-491

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The use of an intermaxillary fixation screw for mandibular setback surgery2008

    • Author(s)
      Koichiro Ueki, Kohei Marukawa, Mayumi Shimada, Kiyomasa Nakagawa, Etsuhide Yamamoto
    • Journal Title

      J Oral Maxillofac Surg 65

      Pages: 1562-1568

    • NAID

      120001140174

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between recovery period of lower lip hypoesthesia and sagittal split area or plate screw position after sagittal split ramus osteotomy2008

    • Author(s)
      Yukari Hashiba, Koichiro Ueki, Kohei Marukawa, Kan Yoshida, Kiyomasa Nakagawa, Etsuhide Yamamoto, Kanya Matsubara
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105

      Pages: 11-15

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Horizontal changes in the condylar head after sagittal split ramus osteotomy with bent plate fixation.2008

    • Author(s)
      Ueki Koichiro, Nakagawa Kiyo masa, et al.
    • Journal Title

      Oral Surgery Oral Medicine Oral Pathology oral Radiology and Endodontics 106

      Pages: 656-661

    • NAID

      120001130405

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The evaluation of surgical factors related to recovery period of upper lip hypoaesthesia after Le Fort I osteotomy.2008

    • Author(s)
      Ueki Koichiro, Nakagawa kiyo masa, et al.
    • Journal Title

      Journal of Cranio-Maxillofacial Surgery 36

      Pages: 390-394

    • NAID

      120001130406

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skeletal stability after mandibular setback surgery : bicortical fixation using a 2.0-mm locking plate system versus monocortical fixation using a nonlocking plate system.2008

    • Author(s)
      Ueki Koichiro, Nakagawa Kiyo masa, et al.
    • Journal Title

      Journal of Oral and Maxillofacial surgery 66

      Pages: 900-904

    • NAID

      120001135532

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] スクリューによる下歯槽神経損傷後の治癒に関する組織学的検討2011

    • Author(s)
      宮崎真凡、上木耕一郎、丸川浩平、岡部克彦、向澤彩、諸井明徳、中川清昌
    • Organizer
      第65回日本口腔科学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Evaluation of bone formation using self-setting α-tricalcium phosphate in saggital split ramus osteotomy with absorbable plate2010

    • Author(s)
      上木耕一郎, 岡部克彦, 丸川浩平, 向澤彩, 諸井明徳, 宮崎真凡, 中川清昌, 山本悦秀
    • Organizer
      9^<th> Asian Congress on Oral & Maxillofacial Surgery
    • Place of Presentation
      Kuala Lumpur convension centre (Malaysia)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery2010

    • Author(s)
      岡部克彦, 上木耕一郎, 丸川浩平, 向澤彩, 宮崎真凡, 中川清昌, 山本悦秀
    • Organizer
      9^<th> Asian Congress on Oral & Maxillofacial Surgery
    • Place of Presentation
      Kuala Lumpur convension centre (Malaysia)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Evaluation of bone formation using seifsetting a-tricalcium phosphate in saggital split ramus osteotomy with absorbable plate2010

    • Author(s)
      Ueki k, nakagawa K, et al
    • Organizer
      9^<th>A sian Congress on Oral Maxillofacial Surgery
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 異なった担体を用いたスタチンによる家兎の骨再生の検討2010

    • Author(s)
      向澤彩、上木耕一郎、丸川浩平、岡部克彦、宮崎真凡、諸井明徳、中川清昌、山本悦秀
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 下顎枝垂直骨切り術(IVRO)後の近位骨片位置変化と下唇知覚の検討2009

    • Author(s)
      上木耕一郎、岡部克彦、羽柴由香里、丸川浩平、向澤彩、宮崎真凡、中川清昌、山本悦秀
    • Organizer
      第19回日本顎変形症学会総会
    • Place of Presentation
      仙台国際センター(宮城)
    • Year and Date
      2009-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 下顎枝垂直骨切り術(IVRO)後の近位骨片位置変化と下唇知覚の検討2009

    • Author(s)
      上木耕一郎、中川清昌, 他
    • Organizer
      第19回日本顎変形症学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mohiuddin Ahmed Statin induced Bone Morphogenetic Protein (BMP)-2 expression during bone regeneration. An immunohistochemical study2008

    • Author(s)
      Shamiul Alam, Koichiro Ueki, Kiyomasa Nakagawa, Kohei Marukawa, Yukari Hashiba, Etsuhide Yamamoto
    • Organizer
      8^<th> Asian Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Bangkok Convention Centre(Thailand)
    • Year and Date
      2008-11-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Pterygomaxillary separation in Le Fort I osteotomy2008

    • Author(s)
      Ueki Koichiro, Nakagawa kiyomasa, et al.
    • Organizer
      XIX Congress of the European Association for Cranio-Maxillofacial Surgery
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sinus floor elevation with autologous bone grafts using platelet rich plasma2008

    • Author(s)
      Nakagawa Kiyomasa, et al.
    • Organizer
      8^<th> Asia Congress on Oral and Maxillof ac ial Surgery
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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