Analysis of roles of p38 MAP kinase in skeletal development.

• Project/Area Number: 20592327
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: AIKAWA Tomonao Osaka University, 歯学部附属病院, 講師 (00362674)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: p38 MAP / キナーゼ / 軟骨細胞 / 破骨細胞 / ノックアウトマウス / p38MAPキナーゼ / トランスジェニックマウス / 関節炎 / p38 MAP キナーゼ

Research Abstract

The aim of this study was to clarify the molecular roles of p38 alpha MAP kinase in cartilage and skeletal development. Briefly, we analyzed 3 independent lines of cartilage specific conditional knock-out mice of p38 alpha isoform. We did not found significant growth and developmental failure in mice, suggesting that p38 alpha isoform might be complemented by other isoforms or redundant.

Research Products

• [Journal Article] Way to increase mechanical strength during distraction osteogenesis of mandibular symphysis : technical note (2010)
  • Author(s): Aikawa T, Ohnishi K, Ohnishi H, Iida S
  • Journal Title: Br J Oral Maxillofac Surg in press
  • Peer Reviewed
• [Journal Article] Rotation movement of the anterior maxillary segment by hybrid distractor in patients with cleft lip and palate (2010)
  • Journal Title: Oral Surg Oral Med Pral Patholo Oral Radiol Endod 110 Pages: 292-300
  • Peer Reviewed
• [Journal Article] 口腔扁平上皮癌の遠隔成績に与える予後因子-リンパ節転を移中心に- (2010)
  • Author(s): 大倉正也, 平沼勉, 鏡内肇, 沢井奈津子, 飯田征二, 石井庄一郎, 相川友直, 古郷幹彦
  • Journal Title: 日本口腔科学会雑誌 59 Pages: 68-78
• [Journal Article] 異時性に発生した両側耳下腺MALTリンパ腫の1例 (2010)
  • Author(s): 沢井奈津子, 大倉正也, 相川友直, 岸野万伸, 増田智丈, 古郷幹彦
  • Journal Title: 日本口腔外科学会雑誌 56 Pages: 18-22
  • NAID: 10027842060
  • Peer Reviewed
• [Journal Article] 含歯性嚢胞から発生した下顎骨顎骨中心性扁平上皮癌の1例 (2009)
  • Author(s): 相川友直, 飯田征二, 徳宮元富, 高尾香名, 沢井奈津子, 田中晋, 福田康夫, 岸野万伸, 大倉正也
  • Journal Title: 大阪大学歯学雑誌 54 Pages: 17-21
  • NAID: 10026063835
• [Journal Article] 関節突起部に生じた周辺性骨腫の1例 (2009)
  • Author(s): 沢井奈津子, 相川友直, 原田計眞, 増田智丈, 太田之博, 古郷幹彦
  • Journal Title: 日本口腔外科学会雑誌 55 Pages: 514-518
  • NAID: 10027091223
  • Peer Reviewed
• [Journal Article] 舌下部に生じた異所性胃粘膜嚢腫の1例 (2009)
  • Author(s): 沢井奈津子, 飯田征二, 相川友直, 岸野万伸, 辻本育子, 古郷幹彦
  • Journal Title: 日本口腔外科学会雑誌 55 Pages: 644-648
  • Peer Reviewed
• [Journal Article] Facial frontal morphological changes related to mandibular setback osteotomy using cephalograms (2009)
  • Author(s): Amano K, Yagi T, Iida S, Aikawa T, Yashiro K, Takada K, Kogo M
  • Journal Title: J Craniomaxillofac Surg 37 Pages: 412-416
  • Peer Reviewed
• [Journal Article] Intraductal papilloma arising from sublingual minor salivary gland : case report and immunohistochemical study (2009)
  • Author(s): Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, Iida S
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(5)
  • Peer Reviewed
• [Journal Article] Decision analysis and treatment threshold in a management for the N0 neck of the oral cavity (2009)
  • Author(s): 大倉正也, 相川友直, 沢井奈津子, 飯田征二, 古郷幹彦
  • Journal Title: Oral Oncolo 45 Pages: 908-911
  • Peer Reviewed
• [Journal Article] Simulation of Osteotomy and Support for Surgery using VR Hepatic Device (2009)
  • Author(s): Sohmura T, Iida S, Aikawa T, Kogo M, Iguchi Y, Yamamoto T, Takada K.
  • Journal Title: Stud Health Technolo Inform 142 Pages: 331-336
  • Peer Reviewed
• [Journal Article] Computed Tomography Followed by Ultrasound Examination Improves Detection of Regional Metastases in Patients with Squamous Cell Carcinoma of the Tongue (2009)
  • Author(s): Sawai NY, Okura M, Tanaka S, Aikawa T, Sasai T, Iida S, Masuda T, Ishii S, Furukawa S, Kogo M
  • Journal Title: 大阪大学歯学雑誌 54 Pages: 9-16
  • NAID: 10026063803
• [Journal Article] 顎矯正手術により長期間咬合の安定が得られた末端肥大症の1例 (2008)
  • Author(s): 相川友直, 太田之博, 飯田征二, 松岡裕大, 高尾香名, 古郷幹彦
  • Journal Title: 日本口腔外科学会雑誌 54 Pages: 234-238
  • NAID: 10027088358
  • Peer Reviewed
• [Journal Article] MR画像で経時的変化を観察した顎関節滑膜軟骨腫症の1例 (2008)
  • Author(s): 榎本明史, 飯田征二, 足立忠文, 相川友直, 小泉英彦, 古郷幹彦
  • Journal Title: 日本口腔外科学会雑誌 54 Pages: 59-63
  • Peer Reviewed
• [Journal Article] Widening a narrow posterior mandibular alveolus following extirpation of a large cyst. -A case treated with a titanium mesh-plate type distractor (2008)
  • Author(s): Aikawa T, Iida S, Senoo H, Hori K, Namikawa M, Okura M, Ono T.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(5)
  • Peer Reviewed
• [Journal Article] An uncommon cleft subtype of unilateral cleft lip and palate (2008)
  • Author(s): Yamanishi T, Kobayashi C, Tsujimoto I, Koizumi H, Miya S, Yokota Y, Okamoto R, Iida S, Aikawa T, Kohara H, Nishio J, Kogo M
  • Journal Title: J Dent Res 87 Pages: 164-168
  • Peer Reviewed
• [Journal Article] Breakage of internal maxillary distractor -Considerable complication of maxillary distraction osteogenesis (2008)
  • Author(s): Aikawa T, Iida S, Isomura ET, Namikawa M, Matsuoka Y, Yamada C, Yamamoto T, Takigawa Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(1)
  • Peer Reviewed
• [Journal Article] Nasolabial cyst in a patient with cleft lip and palate (2008)
  • Author(s): Aikawa T, Iida S, Fukuda Y, Nakano Y, Ota Y, Takao K, Kogo M
  • Journal Title: Int J Oral Maxillofac Surg 37 Pages: 874-876
  • Peer Reviewed
• [Journal Article] Conventional bone-anchored palatal distractor using an orthodontic palatal expander for the transverse maxillary distraction osteogenesis -Technical note- (2008)
  • Author(s): Iida S, Haraguchi S, Aikawa T, Yashiro K, Okura M, Kogo M
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(2)
  • Peer Reviewed
• [Journal Article] 摂食障害が誘因と考えられた口蓋壊死性唾液腺炎の1例 (2008)
  • Author(s): 原田丈司, 相川友直, 川嵜康大, 飯田征二, 岸野万伸, 古郷幹彦
  • Journal Title: 日本口腔科学会雑誌 57 Pages: 311-314
  • NAID: 10021953087
  • Peer Reviewed
• [Journal Article] 線維芽細胞と混合培養条件下での口腔扁平上皮癌細胞の基底膜浸潤の制御-MT1MMPの役割- (2008)
  • Author(s): 松岡裕大, 中原寛和, 久島潔, 大谷朋弘, 能崎晋一, 平岡慎一郎, 永田雅英, 相川友直, 山本悦秀, 古郷幹彦
  • Journal Title: 日本口腔外科学会雑誌 54 Pages: 2-7
  • Peer Reviewed
• [Presentation] 歯原性腫瘍・嚢胞が産生するTGF-bおよびIL-1aは間質線維芽細胞の破骨細胞促進因子発現を促進する (2011)
  • Author(s): 山田智明、相川友直、辻本育子、天野克比古、木全正彰、飯田征二、古郷幹彦
  • Organizer: 第65回日本口腔科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] 眼・歯・指症候群の原因遺伝子GJA1は症候性口唇裂の発症に関与する (2011)
  • Author(s): 石口満津子、相川友直、古郷幹彦
  • Organizer: 第65回日本口腔科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-21
• [Presentation] TGF-b and IL-1a in jaw tumor fluids participate in bone resorption through stimulation of osteoclastgenesis (2010)
  • Author(s): Aikawa T, Yamada C, Tsujimoto I, Amano K, Namba N, Iida S, Kogo M
  • Organizer: American Society for Bone and Mineral Metabolosm Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2010-10-17
• [Presentation] TGF-b and IL-1a in jaw tumor fluids participate in bone reaorption through the stimulation of osteoclastgenesis. (2010)
  • Author(s): 相川友直
  • Organizer: American Society for Bone and Mineral Research
  • Place of Presentation: カナダ・トロント
  • Year and Date: 2010-10-17
• [Presentation] 開口障害を伴った小児の下顎骨類腱線維腫の1例 (2010)
  • Author(s): 川島ひとみ, 相川友直, 増田智丈, 岸野万伸, 福田康夫, 大槻浩一, 谷口佳孝, 山本奈穂, 古郷幹彦
  • Organizer: 題64回日本口腔科学会
  • Year and Date: 2010-06-24
• [Presentation] Hybrid型延長装置を用いて側方回転を伴う上顎骨前方部の骨延長術を行った唇顎口蓋裂症例 (2010)
  • Author(s): 田中晋, 飯田征二, 相川友直, 石橋美樹, 阿部早苗, 古郷幹彦
  • Organizer: 第34回日本口蓋裂学会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-28
• [Presentation] Maxillary anterior segmental distraction osteogenesis by hybrid distractor successfully demonstrate the rotational segmental movements in patients with cleft lip and cleft palate (2010)
  • Author(s): 田中晋, 飯田征二, 相川友直, 石橋美樹, 古郷幹彦
  • Organizer: 67rd annual meeting of American cleft palate-craniofacial association
  • Place of Presentation: Fort Worth, USA
  • Year and Date: 2010-03-17
• [Presentation] 口腔癌N0 頸部の治療方針に関する決定樹解析と治療閾値 (2009)
  • Author(s): 沢井奈津子, 大倉正也, 相川友直, 永田雅英, 石本俊介, 飯田征二, 増田智丈, 古郷幹彦
  • Organizer: 第54回日本口腔外科学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-10
• [Presentation] 異時性に発生した両側耳下腺MALTリンパ腫の1例 (2009)
  • Author(s): 石本俊介, 沢井奈津子, 大倉正也, 相川友直, 岸野万伸, 増田智丈, 古郷幹彦
  • Organizer: 第54回日本口腔外科学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-10
• [Presentation] ビスフォスフォネート系薬剤関連顎骨壊死(BRONJ)の診断と治療 (2009)
  • Author(s): 相川友直
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-23
• [Presentation] Hybrid typeの延装置を用いた上顎骨の水平的延長術 (2008)
  • Author(s): 相川友直, 飯田征二, 石橋美樹, 小泉英彦, 磯村恵美子, 阿部早苗, 古郷幹彦
  • Organizer: 第53回日本口腔外科学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] 第53回日本口腔外科学会 (2008)
  • Author(s): 増田智丈, 相川友直, 磯村恵美子, 飯田征二, 松田智子, 岸野万伸, 田中晋, 古郷幹彦
  • Organizer: 舌下部に発生したIntraductal papillomaの1例
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] 口腔悪性腫瘍手術施行症例における術後感染について (2008)
  • Author(s): 樋口将隆, 石浜孝二, 田中晋, 住岡聡, 和田剛信, 吉村奈津子, 相川友直, 大倉正也, 古郷幹彦
  • Organizer: 第53回日本口腔外科学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20