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Analysis of roles of p38 MAP kinase in skeletal development.

Research Project

Project/Area Number 20592327
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

AIKAWA Tomonao  Osaka University, 歯学部附属病院, 講師 (00362674)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsp38 MAP / キナーゼ / 軟骨細胞 / 破骨細胞 / ノックアウトマウス / p38MAPキナーゼ / トランスジェニックマウス / 関節炎 / p38 MAP キナーゼ
Research Abstract

The aim of this study was to clarify the molecular roles of p38 alpha MAP kinase in cartilage and skeletal development. Briefly, we analyzed 3 independent lines of cartilage specific conditional knock-out mice of p38 alpha isoform. We did not found significant growth and developmental failure in mice, suggesting that p38 alpha isoform might be complemented by other isoforms or redundant.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 2008

All Journal Article (21 results) (of which Peer Reviewed: 18 results) Presentation (13 results)

  • [Journal Article] Way to increase mechanical strength during distraction osteogenesis of mandibular symphysis : technical note2010

    • Author(s)
      Aikawa T, Ohnishi K, Ohnishi H, Iida S
    • Journal Title

      Br J Oral Maxillofac Surg in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rotation movement of the anterior maxillary segment by hybrid distractor in patients with cleft lip and palate2010

    • Journal Title

      Oral Surg Oral Med Pral Patholo Oral Radiol Endod 110

      Pages: 292-300

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔扁平上皮癌の遠隔成績に与える予後因子-リンパ節転を移中心に-2010

    • Author(s)
      大倉正也, 平沼勉, 鏡内肇, 沢井奈津子, 飯田征二, 石井庄一郎, 相川友直, 古郷幹彦
    • Journal Title

      日本口腔科学会雑誌 59

      Pages: 68-78

    • Related Report
      2010 Final Research Report
  • [Journal Article] 異時性に発生した両側耳下腺MALTリンパ腫の1例2010

    • Author(s)
      沢井奈津子, 大倉正也, 相川友直, 岸野万伸, 増田智丈, 古郷幹彦
    • Journal Title

      日本口腔外科学会雑誌 56

      Pages: 18-22

    • NAID

      10027842060

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 含歯性嚢胞から発生した下顎骨顎骨中心性扁平上皮癌の1例2009

    • Author(s)
      相川友直, 飯田征二, 徳宮元富, 高尾香名, 沢井奈津子, 田中晋, 福田康夫, 岸野万伸, 大倉正也
    • Journal Title

      大阪大学歯学雑誌 54

      Pages: 17-21

    • NAID

      10026063835

    • Related Report
      2010 Final Research Report
  • [Journal Article] 関節突起部に生じた周辺性骨腫の1例2009

    • Author(s)
      沢井奈津子, 相川友直, 原田計眞, 増田智丈, 太田之博, 古郷幹彦
    • Journal Title

      日本口腔外科学会雑誌 55

      Pages: 514-518

    • NAID

      10027091223

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 舌下部に生じた異所性胃粘膜嚢腫の1例2009

    • Author(s)
      沢井奈津子, 飯田征二, 相川友直, 岸野万伸, 辻本育子, 古郷幹彦
    • Journal Title

      日本口腔外科学会雑誌 55

      Pages: 644-648

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Facial frontal morphological changes related to mandibular setback osteotomy using cephalograms2009

    • Author(s)
      Amano K, Yagi T, Iida S, Aikawa T, Yashiro K, Takada K, Kogo M
    • Journal Title

      J Craniomaxillofac Surg 37

      Pages: 412-416

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraductal papilloma arising from sublingual minor salivary gland : case report and immunohistochemical study2009

    • Author(s)
      Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, Iida S
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(5)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decision analysis and treatment threshold in a management for the N0 neck of the oral cavity2009

    • Author(s)
      大倉正也, 相川友直, 沢井奈津子, 飯田征二, 古郷幹彦
    • Journal Title

      Oral Oncolo 45

      Pages: 908-911

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simulation of Osteotomy and Support for Surgery using VR Hepatic Device2009

    • Author(s)
      Sohmura T, Iida S, Aikawa T, Kogo M, Iguchi Y, Yamamoto T, Takada K.
    • Journal Title

      Stud Health Technolo Inform 142

      Pages: 331-336

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computed Tomography Followed by Ultrasound Examination Improves Detection of Regional Metastases in Patients with Squamous Cell Carcinoma of the Tongue2009

    • Author(s)
      Sawai NY, Okura M, Tanaka S, Aikawa T, Sasai T, Iida S, Masuda T, Ishii S, Furukawa S, Kogo M
    • Journal Title

      大阪大学歯学雑誌 54

      Pages: 9-16

    • NAID

      10026063803

    • Related Report
      2010 Final Research Report
  • [Journal Article] 顎矯正手術により長期間咬合の安定が得られた末端肥大症の1例2008

    • Author(s)
      相川友直, 太田之博, 飯田征二, 松岡裕大, 高尾香名, 古郷幹彦
    • Journal Title

      日本口腔外科学会雑誌 54

      Pages: 234-238

    • NAID

      10027088358

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MR画像で経時的変化を観察した顎関節滑膜軟骨腫症の1例2008

    • Author(s)
      榎本明史, 飯田征二, 足立忠文, 相川友直, 小泉英彦, 古郷幹彦
    • Journal Title

      日本口腔外科学会雑誌 54

      Pages: 59-63

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Widening a narrow posterior mandibular alveolus following extirpation of a large cyst. -A case treated with a titanium mesh-plate type distractor2008

    • Author(s)
      Aikawa T, Iida S, Senoo H, Hori K, Namikawa M, Okura M, Ono T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(5)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An uncommon cleft subtype of unilateral cleft lip and palate2008

    • Author(s)
      Yamanishi T, Kobayashi C, Tsujimoto I, Koizumi H, Miya S, Yokota Y, Okamoto R, Iida S, Aikawa T, Kohara H, Nishio J, Kogo M
    • Journal Title

      J Dent Res 87

      Pages: 164-168

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Breakage of internal maxillary distractor -Considerable complication of maxillary distraction osteogenesis2008

    • Author(s)
      Aikawa T, Iida S, Isomura ET, Namikawa M, Matsuoka Y, Yamada C, Yamamoto T, Takigawa Y
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nasolabial cyst in a patient with cleft lip and palate2008

    • Author(s)
      Aikawa T, Iida S, Fukuda Y, Nakano Y, Ota Y, Takao K, Kogo M
    • Journal Title

      Int J Oral Maxillofac Surg 37

      Pages: 874-876

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conventional bone-anchored palatal distractor using an orthodontic palatal expander for the transverse maxillary distraction osteogenesis -Technical note-2008

    • Author(s)
      Iida S, Haraguchi S, Aikawa T, Yashiro K, Okura M, Kogo M
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 摂食障害が誘因と考えられた口蓋壊死性唾液腺炎の1例2008

    • Author(s)
      原田丈司, 相川友直, 川嵜康大, 飯田征二, 岸野万伸, 古郷幹彦
    • Journal Title

      日本口腔科学会雑誌 57

      Pages: 311-314

    • NAID

      10021953087

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 線維芽細胞と混合培養条件下での口腔扁平上皮癌細胞の基底膜浸潤の制御-MT1MMPの役割-2008

    • Author(s)
      松岡裕大, 中原寛和, 久島潔, 大谷朋弘, 能崎晋一, 平岡慎一郎, 永田雅英, 相川友直, 山本悦秀, 古郷幹彦
    • Journal Title

      日本口腔外科学会雑誌 54

      Pages: 2-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 歯原性腫瘍・嚢胞が産生するTGF-bおよびIL-1aは間質線維芽細胞の破骨細胞促進因子発現を促進する2011

    • Author(s)
      山田智明、相川友直、辻本育子、天野克比古、木全正彰、飯田征二、古郷幹彦
    • Organizer
      第65回日本口腔科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 眼・歯・指症候群の原因遺伝子GJA1は症候性口唇裂の発症に関与する2011

    • Author(s)
      石口満津子、相川友直、古郷幹彦
    • Organizer
      第65回日本口腔科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-21
    • Related Report
      2010 Final Research Report
  • [Presentation] TGF-b and IL-1a in jaw tumor fluids participate in bone resorption through stimulation of osteoclastgenesis2010

    • Author(s)
      Aikawa T, Yamada C, Tsujimoto I, Amano K, Namba N, Iida S, Kogo M
    • Organizer
      American Society for Bone and Mineral Metabolosm Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] TGF-b and IL-1a in jaw tumor fluids participate in bone reaorption through the stimulation of osteoclastgenesis.2010

    • Author(s)
      相川友直
    • Organizer
      American Society for Bone and Mineral Research
    • Place of Presentation
      カナダ・トロント
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 開口障害を伴った小児の下顎骨類腱線維腫の1例2010

    • Author(s)
      川島ひとみ, 相川友直, 増田智丈, 岸野万伸, 福田康夫, 大槻浩一, 谷口佳孝, 山本奈穂, 古郷幹彦
    • Organizer
      題64回日本口腔科学会
    • Year and Date
      2010-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Hybrid型延長装置を用いて側方回転を伴う上顎骨前方部の骨延長術を行った唇顎口蓋裂症例2010

    • Author(s)
      田中晋, 飯田征二, 相川友直, 石橋美樹, 阿部早苗, 古郷幹彦
    • Organizer
      第34回日本口蓋裂学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Maxillary anterior segmental distraction osteogenesis by hybrid distractor successfully demonstrate the rotational segmental movements in patients with cleft lip and cleft palate2010

    • Author(s)
      田中晋, 飯田征二, 相川友直, 石橋美樹, 古郷幹彦
    • Organizer
      67rd annual meeting of American cleft palate-craniofacial association
    • Place of Presentation
      Fort Worth, USA
    • Year and Date
      2010-03-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔癌N0 頸部の治療方針に関する決定樹解析と治療閾値2009

    • Author(s)
      沢井奈津子, 大倉正也, 相川友直, 永田雅英, 石本俊介, 飯田征二, 増田智丈, 古郷幹彦
    • Organizer
      第54回日本口腔外科学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 異時性に発生した両側耳下腺MALTリンパ腫の1例2009

    • Author(s)
      石本俊介, 沢井奈津子, 大倉正也, 相川友直, 岸野万伸, 増田智丈, 古郷幹彦
    • Organizer
      第54回日本口腔外科学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] ビスフォスフォネート系薬剤関連顎骨壊死(BRONJ)の診断と治療2009

    • Author(s)
      相川友直
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Hybrid typeの延装置を用いた上顎骨の水平的延長術2008

    • Author(s)
      相川友直, 飯田征二, 石橋美樹, 小泉英彦, 磯村恵美子, 阿部早苗, 古郷幹彦
    • Organizer
      第53回日本口腔外科学会
    • Place of Presentation
      徳島
    • Year and Date
      2008-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 第53回日本口腔外科学会2008

    • Author(s)
      増田智丈, 相川友直, 磯村恵美子, 飯田征二, 松田智子, 岸野万伸, 田中晋, 古郷幹彦
    • Organizer
      舌下部に発生したIntraductal papillomaの1例
    • Place of Presentation
      徳島
    • Year and Date
      2008-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔悪性腫瘍手術施行症例における術後感染について2008

    • Author(s)
      樋口将隆, 石浜孝二, 田中晋, 住岡聡, 和田剛信, 吉村奈津子, 相川友直, 大倉正也, 古郷幹彦
    • Organizer
      第53回日本口腔外科学会
    • Place of Presentation
      徳島
    • Year and Date
      2008-10-20
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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