Regulate for invasiveness by epithelial?mesenchymal interaction of oral cancer.
| Project/Area Number |
20592328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAHARA Hirokazu Osaka University, 大学院・歯学研究科, 招聘教員 (70324796)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUOKA YudaI 大阪大学, 大学院・歯学研究科, 招聘教員 (50448148)
KOGO Mikihiko 大阪大学, 大学院・歯学研究科, 教授 (20205371)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 口腔外科学一般 / 浸潤・転移 / 口腔扁平上皮癌 / 上皮-間葉相互作用 / クロマチンコンプレックス / 低分子Gたんぱく質 |
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| Research Abstract |
We examined the target molecule of the molecular target treatment with the goal of a metastasis control.by using the fibronectin resolution/invasion model that could observe the extracellular matrix resolution due to the cancer cell in vitro. We used the OSC-19 cells which were cell line derived from two kinds of different human oral squamous cell carcinomas of the invasion style and OSC-20 cells. The reptin gene knockdown cells and compared cellular infiltration/the migration ability and compared the manifestation of the transcriptional regulator of activity of the basal membrane splitting enzyme, manifestation of small molecule GTP-binding protein, epithelial mesenchymal transition (EMT) related protein and EMT.
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Report
(4 results)
Research Products
(18 results)
