| Project/Area Number |
20592332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
YAMADA Tomohiro Okayama University, 教育研究部・医療学系, 准教授 (60335619)
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Katsuaki 山口大学, 大学院・医学系研究科, 准教授 (60304317)
HIRATA Azumi 大阪大学, 大学院・工学研究科, 特任研究員 (40263587)
MATSUMURA Tatsushi 岡山大学, 病院, 助教 (70432648)
MORITANI Norifumi 岡山大学, 病院, 助教 (60467751)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口蓋裂 / マウス / ダイオキシン / 解離 / 接着因子 |
|---|
| Research Abstract |
Mice treated with TCDD (2, 3, 7, 8-tetrachrolodibenzo dioxin) develop cleft palate following disruption, regardless the palate once fused. Factors related to the disruption of the palate, were considered for the lack of physical strength of the tissues. Therefore, intercellular adhesion molecule and basement membrane components were analyzed in this study. As a result, TCDD decreased expression of these molecules. Furthermore, morphologically bony hypoplasia was observed in the palatal bone of TCDD-treated group.
In conclusion, TCDD pathogenesis of cleft palate in mice was suggested to be caused by not only insufficient strength of palatal epithelium, but also hypoplasia of the muscles and bone.
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