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腫瘍壊死因子とアクアポリン5を分子標的としたシェーグレン症候群の新規治療法の開発

Research Project

Project/Area Number 20592337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

MOTEGI Katsumi  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (20335805)

Co-Investigator(Kenkyū-buntansha) AZUMA Masayuki  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20144983)
TAMATANI Tetsuya  徳島大学, 病院, 講師 (30274236)
UCHIDA Daisuke  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (20335798)
FUJISAWA Kenji  徳島大学, 病院, 講師 (40228979)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsシェーグレン症候群 / 唾液分泌 / アクアポリン / 腫瘍壊死因子
Research Abstract

Sjogren's syndrome (SS) is a systemic autoimmune disease that involves a reduction in salivary and lacrimal secretions, however, the mechanisms underlying the decrease in salivary secretion remains unclear. In salivary glands of SS patients, the expression of aquaporin (AQP) 5, a major water channel present in the apical plasma membrane, was decreased and aberrant distribution of AQP5 from apical to basal membrane was reported. The mechanisms of AQP5 dysfunction in SS salivary glands have not yet fully understood. Since it has been reported that the expression level of AQP5 gene was suppressed by tumor necrosis factor (TNF)-α in mouse lung epithelial cells in vitro, one of the key factors that reduce AQP5 expression in salivary acinar cells would be TNF-α. In this study, we examined the role of TNF-5 in human salivary gland acinar cells.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Differential involvement of TGF-betal in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells.2008

    • Author(s)
      Motegi K, Harada K, Ohe G, Jones SJ, Ellis IR, Crouch DH, Schor SL, Schor AM,.
    • Journal Title

      Experimental Cell Research 314

      Pages: 2323-2333

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of TGF-betal in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells.2008

    • Author(s)
      K Motegi
    • Journal Title

      Experimental Cell Research 314

      Pages: 2323-2333

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] シェーグレン症候群唾液腺へのリンパ球浸潤における性ホルモン就職酵素の役割2010

    • Author(s)
      茂木勝美
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知県 高知城ホール
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] シェーグレン症候群唾液腺へのリンパ球浸潤における性ホルモン修飾酵素の役割2010

    • Author(s)
      茂木勝美
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知県 高知城ホール
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] シェーグレン症候群唾液腺へのリンパ球浸潤における性ホルモン就職酵素の役割2010

    • Author(s)
      茂木勝美
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉県 幕張メッセ
    • Year and Date
      2010-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] シェーグレン症候群唾液腺へのリンパ球浸潤における性ホルモン修飾酵素の役割2010

    • Author(s)
      茂木勝美
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉 幕張メッセ
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト唾液腺細胞におけるアクアポリン5の発現誘導の解析2009

    • Author(s)
      茂木勝美
    • Organizer
      第63回日本口腔科学会学術総会
    • Place of Presentation
      静岡県 アクトシティ浜松
    • Year and Date
      2009-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] TNF-αによるヒト唾液腺腺房細胞におけるアクアポリン5発現抑制機構2009

    • Author(s)
      茂木勝美
    • Organizer
      日本口腔科学会学術総会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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