Trace element analysis of the tissue from the oral lichen planus patients by the PIXE method

• Project/Area Number: 20592342
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Iwate Medical University
• Principal Investigator: SUGIYAMA Yoshiki 岩手医科大学, 歯学部, 教授 (00162909)
• Co-Investigator(Kenkyū-buntansha): SERA Kouichiro 岩手医科大学, 医学部, 教授 (00230855)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯学 / 臨床 / 分析化学 / 加速器 / 人間生活環境 / 口腔外科一般 / 口腔扁平苔癬 / 金属元素

Research Abstract

We made a comparative study of trace elements in the oral mucosa of 31 patients with oral lichen planus(OLP) and of 100 healthy persons by the Particle Induced X-ray Emission(PIXE) method in order to clarify the causes of OLP. The results were as follows : Seventeen trace elements and 11 contaminating elements were detected. As for the females over 30 years old, the OLP group showed significantly higher values of Si, Fe, Zn, Al and Sr than the control group. The mean values of the other essential and contaminating elements did not differ significantly between the groups, although there was a trend toward higher values in the OLP group. We found by the PIXE method that Zn, Fe and Pd, which are d-transitional elements, showed higher values in the oral mucosa of the OLP patients than in those of the healthy persons.

Research Products

• [Journal Article] Oral Lichenoid Drug Reaction with Autoantibodies in Peripheral Blood : Case Report (2011)
  • Author(s): Kumagai, A., Matsuo, M., Hoshi, H., Sato, H., Takeda, Y. and Sugiyama, Y.
  • Journal Title: Oral Sciense International Volume: 8 Pages: 29-33
  • NAID: 10030270697
  • Peer Reviewed
• [Journal Article] High-cell density-induced VCAM1 expression inhibits the migratory ability of mesenchymal stem cells (2011)
  • Author(s): Nishihira, S., Okubo, N., Takahashi, N., Ishiski, A., Sugiyama, Y., Chosa, N.
  • Journal Title: Cell Biology International Volume: 35 Pages: 475-481
  • Peer Reviewed
• [Journal Article] Oral Lichenoid Drug Reaction with Autoantibodies in Peripheral Blood : Case Report (2011)
  • Author(s): Kumagai, A., Matsuo, M., Hoshi, H., Sato, H., Takeda, Y., Sugiyama, Y.
  • Journal Title: Oral Sciense International in press
  • NAID: 10030270697
  • Peer Reviewed
• [Journal Article] Lichenoid Drug Reaction with Autoantibodies in Peripheral Blood : Case Report (2011)
  • Author(s): Kumagai, A
  • Journal Title: Oral Science International Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Clinical significance of combined CYP2C9 and VKORC1 genotype in Japanese patients requiring warfarin (2011)
  • Author(s): Miyagata, Y.
  • Journal Title: Int.Heart J. Volume: 52 Pages: 44-49
  • Peer Reviewed
• [Journal Article] Studies on Changes of Elemental Concentration in a Human Body by Means of Analyses of Long Hairs on the Basis of the Standard-Free Method. (2009)
  • Author(s): Sera, K., Terasaki, K., Sasaki, T., Goto, S., Saitoh, Y. and Itoh, J.
  • Journal Title: Int' l Journal of PIXE Volume: Vol.19-1, 2 Pages: 17-27
  • Peer Reviewed
• [Journal Article] 舌神経腫瘤を初発症状とした舌下腺原発腺様嚢胞癌の一例 (2009)
  • Author(s): 熊谷章子
  • Journal Title: 口腔腫瘍 21 Pages: 279-284
  • Peer Reviewed
• [Journal Article] 舌下腺に原発し超音波パワードップラー法が診断に有効であった悪性リンパ腫の1例 (2009)
  • Author(s): 東海林理
  • Journal Title: 岩医大歯誌 34 Pages: 22-28
  • Peer Reviewed
• [Journal Article] 小児の顔面外傷-軟組織外傷と骨折- (2009)
  • Author(s): 杉山芳樹
  • Journal Title: 小児歯科臨床 14 Pages: 22-31
• [Journal Article] Quantitative analysis of very small quantity of organs taken from patients and experimental animals ; standard-free method for organ samples (2008)
  • Author(s): Sera, K., Itoh, J., Goto, S., Saitoh, Y., Fujimura, A., Nosaka, Y., Noda, Y., Nishizuka, S. and Wakabayashi, G.
  • Journal Title: Int' l Journal of PIXE Volume: 18-3, 4 Pages: 111-122
  • Peer Reviewed
• [Journal Article] Tumoral calcium pyrophosphoate dihydrate crystal deposition disease of the temproromandibular joint : Identification on crystallography (2008)
  • Author(s): Mikami, T., Takeda, Y., Ohira, A., Hoshi, H., Sugiyama, Y., Yoshida, Y., Ambo, J.
  • Journal Title: Pathology Internationa 58 Pages: 723-729
  • Peer Reviewed
• [Journal Article] Quantitative analysis of very small quantity of organs taken from patients and experimental animals ; standard-free method for organ samples (2008)
  • Author(s): Sera, K., Itoh, J., Goto, S., Saitoh, Y., Fujimura, A., Nosaka, Y., Noda, Y., Nishizuka, S., Wakabayashi, G.
  • Journal Title: Int'l Journal of PIXE 18-3,4 Pages: 111-122
  • Peer Reviewed
• [Journal Article] Tumoral calcium pyrophosphate dihydrate crystal deposition disease of temporomandibural joint. : Identification on crystallography (2008)
  • Author(s): Toshinari Mikami
  • Journal Title: Pathlogy International 58 Pages: 723-729
  • Peer Reviewed
• [Journal Article] 臨床的に唾液腺腫瘍が疑われたB細胞系悪性リンパ腫の3症例 (2008)
  • Author(s): 熊谷章子
  • Journal Title: 日本口腔診断学会雑誌 21 Pages: 262-267
  • Peer Reviewed
• [Presentation] ^<18> F-Choline PETによる口腔癌の診断 (2011)
  • Author(s): 原康文、杉山芳樹、星秀樹、熊谷章子、飯島伸、松本直子
  • Organizer: 第29回日本口腔腫瘍学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-01-27
• [Presentation] ^<18>F-Choline PETによる口腔癌の診断 (2011)
  • Author(s): 原康文、杉山芳樹、星秀樹、熊谷章子、飯島伸、松本直子
  • Organizer: 第29回日本口腔腫瘍学会
  • Place of Presentation: 鹿児島
• [Presentation] 炭酸リチウム服用者に発症した薬物誘発性口腔扁平苔癬-唾液・血清リチウム濃度の比較と病態に関する検討- (2010)
  • Author(s): 熊谷章子
  • Organizer: 第64回日本口腔科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-24
• [Presentation] ワルファリン薬物代謝酵素の遺伝子多型の解析と口腔外科領域での個別化医療 (2010)
  • Author(s): 宮形養
  • Organizer: 第64回日本口腔科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-24
• [Presentation] 顎関節滑膜軟骨腫症の病理学的検討 (2009)
  • Author(s): 三上俊成
  • Organizer: 第35回岩手医科大学歯学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-12-05
• [Presentation] ^<18> F-Choline PET検査で脳腫瘍が発見された前立腺癌下顎骨転移の1例 (2009)
  • Author(s): 原康文、古屋出、熊谷章子、寺崎一典、星秀樹、小豆島正典、杉山芳樹
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 頭頸部扁平上皮癌における頸部リンパ節転移の臨床病理学的検討 (2009)
  • Author(s): 星秀樹
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 18F-Choline PET検査で脳腫瘍が発見された前立腺癌下顎骨転移の1例 (2009)
  • Author(s): 原康文
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] Gardner症候群の1例 (2009)
  • Author(s): 古屋出
  • Organizer: 第19回日本口腔粘膜学会
  • Place of Presentation: 横須賀
  • Year and Date: 2009-06-05
• [Presentation] A patient with drug-induced oral lichen planus who had autoantibody in peripheral blood (2009)
  • Author(s): Kumagai, A., Matsuo, S., Furuuchi, H., Hoshi, H. and Sugiyama, Y.
  • Organizer: The 19th International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Shanghai(China)
  • Year and Date: 2009-05-25
• [Presentation] A patient with drug-induced oral lichen planus who had autoantibody in peripheral blood (2009)
  • Author(s): Kumagai, A., Matsuo, S., Furuuchi, H., Hoshi, H., Sugiyama, Y.
  • Organizer: The 19th International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Shanghai (China)
  • Year and Date: 2009-05-25
• [Presentation] A patient with drug-induced oral lichen planus who had autoantibody in peripheral blood (2009)
  • Author(s): Kumagai, A
  • Organizer: The 19th International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-05-25
• [Presentation] A case of malignant lymphoma in the sublingual space (2008)
  • Author(s): Shoji, S., Kumagai, A.,Izumisawa, M., Takahashi, N., Sugiyama, Y., Shozushima, M.
  • Organizer: The 7th Asian Congress of Oral and Maxillofacial Radiology
  • Place of Presentation: Nara (Japan)
  • Year and Date: 2008-11-20
• [Presentation] FDG-PETを用いたがん検診で発見された口腔良性腫瘍の2例 (2008)
  • Author(s): 松本直子、飯島伸、熊谷章子、星秀樹、小豆島正典、杉山芳樹
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] 顎関節症状から明らかになった若年性特発性関節炎の1例 (2008)
  • Author(s): 熊谷章子
  • Organizer: 第21回日本顎関節学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-27
• [Presentation] 唾液腺原発悪性リンパ腫の臨床病理学的解析 (2008)
  • Author(s): 熊谷章子
  • Organizer: 岩手医科大学歯学会第66回例会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-07-05
• [Book] 開業医が診る口腔粘膜疾患 (2010)
  • Author(s): 杉山芳樹
  • Publisher: デンタルダイヤモンド社
• [Remarks]
  • URL: http://www-os2.iwate-med.ac.jp/research.html