| Project/Area Number |
20592343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
KOBAYASHI Akio Saitama Medical University, 医学部, 准教授 (60129153)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Takahiro 埼玉医科大学, 医学部, 助教 (20383250)
SATO Tuyoshi 埼玉医科大学, 医学部, 助教 (60406494)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | アフタ / ストレス / 糖質コルチコイド / クロモグラニンA / γδTCR / コルチコステロイド / 唾液 / サーカディアンリズム / コルチコステロド |
|---|
| Research Abstract |
The mechanism of onset of aphtha has not been well-elucidated, and diagnosis of aphtha is based entirely on current medical history and clinical findings. As a result, no objective guidelines that serve as the basis of diagnosis are currently available. No fundamental treatments have been established, and only palliative care is given at present. In the present study, we investigated the roles of stress and immune mechanisms, which are known to be causes of aphthous stomatitis. Measurement of salivary stress markers revealed the possibility that these markers vary depending on the sensitivity of the individual to stomatitis. The results indicated the possibility that clock genes in immunocytes are inducibly expressed in response to glucocorticoids (GC), and that γδT cells have immunocompetence. In addition, the circadian rhythm was found to be directly influenced by stress signals. The above findings suggest that onset of aphtha may be related to variations in GC caused by stress and abnormalities in circadian rhythm.
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